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Complete Hydatidiform Mole
Paula J. Woodward, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Complete hydatidiform mole (CHM)
          • Synonyms

            • Complete mole
            • Classic mole
            • Molar pregnancy
          • Definitions

            • Trophoblastic proliferation (both cytotrophoblast and syncytiotrophoblast) and vesicular swelling of placental villi associated with absent fetus
            • Most common (~ 76% of all cases) type of gestational trophoblastic disease, which also includes
              • Partial mole (triploidy)
              • Invasive mole (chorioadenoma destruens)
              • Choriocarcinoma
              • Placental-site trophoblastic tumor
              • Epithelioid trophoblastic tumor

          IMAGING

          • General Features

            • Ultrasonographic Findings

              • CT Findings

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Eysbouts YK et al: Trends in incidence for gestational trophoblastic disease over the last 20years in a population-based study. Gynecol Oncol. 140(1):70-5, 2016
                                      2. Carey L et al: Molecular genetic studies of complete hydatidiform moles. Transl Pediatr. 4(2):181-8, 2015
                                      3. Eagles N et al: Risk of recurrent molar pregnancies following complete and partial hydatidiform moles. Hum Reprod. 30(9):2055-63, 2015
                                      4. Gadducci A et al: Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia. Gynecol Endocrinol. 31(9):673-8, 2015
                                      5. Jean-Jacques C: The hydatidiform mole. Cell Adh Migr. 1-10, 2015
                                      6. von Welser SF et al: Invasive mole in a perimenopausal woman: a case report and systematic review. Arch Gynecol Obstet. 292(6):1193-9, 2015
                                      7. Froeling FE et al: Gestational trophoblastic tumours: an update for 2014. Curr Oncol Rep. 16(11):408, 2014
                                      8. Nguyen NM et al: Genetics and epigenetics of recurrent hydatidiform moles: basic science and genetic counselling. Curr Obstet Gynecol Rep. 3:55-64, 2014
                                      9. Shanbhogue AK et al: Gestational trophoblastic disease. Radiol Clin North Am. 51(6):1023-34, 2013
                                      10. Ronnett BM et al: Hydatidiform moles: ancillary techniques to refine diagnosis. Int J Gynecol Pathol. 30(2):101-16, 2011
                                      11. Lurain JR: Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 203(6):531-9, 2010
                                      12. Zhou Q et al: Sonographic and Doppler imaging in the diagnosis and treatment of gestational trophoblastic disease: a 12-year experience. J Ultrasound Med. 24(1):15-24, 2005
                                      13. Benson CB et al: Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol. 16(2):188-91, 2000
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Complete hydatidiform mole (CHM)
                                              • Synonyms

                                                • Complete mole
                                                • Classic mole
                                                • Molar pregnancy
                                              • Definitions

                                                • Trophoblastic proliferation (both cytotrophoblast and syncytiotrophoblast) and vesicular swelling of placental villi associated with absent fetus
                                                • Most common (~ 76% of all cases) type of gestational trophoblastic disease, which also includes
                                                  • Partial mole (triploidy)
                                                  • Invasive mole (chorioadenoma destruens)
                                                  • Choriocarcinoma
                                                  • Placental-site trophoblastic tumor
                                                  • Epithelioid trophoblastic tumor

                                              IMAGING

                                              • General Features

                                                • Ultrasonographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Eysbouts YK et al: Trends in incidence for gestational trophoblastic disease over the last 20years in a population-based study. Gynecol Oncol. 140(1):70-5, 2016
                                                                          2. Carey L et al: Molecular genetic studies of complete hydatidiform moles. Transl Pediatr. 4(2):181-8, 2015
                                                                          3. Eagles N et al: Risk of recurrent molar pregnancies following complete and partial hydatidiform moles. Hum Reprod. 30(9):2055-63, 2015
                                                                          4. Gadducci A et al: Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia. Gynecol Endocrinol. 31(9):673-8, 2015
                                                                          5. Jean-Jacques C: The hydatidiform mole. Cell Adh Migr. 1-10, 2015
                                                                          6. von Welser SF et al: Invasive mole in a perimenopausal woman: a case report and systematic review. Arch Gynecol Obstet. 292(6):1193-9, 2015
                                                                          7. Froeling FE et al: Gestational trophoblastic tumours: an update for 2014. Curr Oncol Rep. 16(11):408, 2014
                                                                          8. Nguyen NM et al: Genetics and epigenetics of recurrent hydatidiform moles: basic science and genetic counselling. Curr Obstet Gynecol Rep. 3:55-64, 2014
                                                                          9. Shanbhogue AK et al: Gestational trophoblastic disease. Radiol Clin North Am. 51(6):1023-34, 2013
                                                                          10. Ronnett BM et al: Hydatidiform moles: ancillary techniques to refine diagnosis. Int J Gynecol Pathol. 30(2):101-16, 2011
                                                                          11. Lurain JR: Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 203(6):531-9, 2010
                                                                          12. Zhou Q et al: Sonographic and Doppler imaging in the diagnosis and treatment of gestational trophoblastic disease: a 12-year experience. J Ultrasound Med. 24(1):15-24, 2005
                                                                          13. Benson CB et al: Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol. 16(2):188-91, 2000