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Congenital CMV
Miral D. Jhaveri, MD; Gary L. Hedlund, DO
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Congenital cytomegalovirus (CMV)
            • Synonyms

              • Human cytomegalovirus (HCMV)
            • Definitions

              • Congenital infection caused by transplacental transmission of CMV, a member of herpes virus family
                • Most common source of intrauterine infection in USA

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Capretti MG et al: Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection. Brain Dev. 36(3):203-11, 2014
                                              2. Alarcon A et al: Clinical, biochemical, and neuroimaging findings predict long-term neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr. 163(3):828-34, 2013
                                              3. Fink KR et al: Neuroimaging of pediatric central nervous system cytomegalovirus infection. Radiographics. 30(7):1779-96, 2010
                                              4. Lanari M et al: Neuroimaging in CMV congenital infected neonates: how and when. Early Hum Dev. 88 Suppl 2:S3-5, 2012
                                              5. Manara R et al: Brain magnetic resonance findings in symptomatic congenital cytomegalovirus infection. Pediatr Radiol. 41(8):962-70, 2011
                                              6. Malinger G et al: Imaging of fetal cytomegalovirus infection. Fetal Diagn Ther. 29(2):117-26, 2011
                                              7. O'Driscoll MC et al: Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria. Am J Hum Genet. 87(3):354-64, 2010
                                              8. Benoist G et al: Cytomegalovirus-related fetal brain lesions: comparison between targeted ultrasound examination and magnetic resonance imaging. Ultrasound Obstet Gynecol. 32(7):900-5, 2008
                                              9. Briggs TA et al: Band-like intracranial calcification with simplified gyration and polymicrogyria: a distinct "pseudo-TORCH" phenotype. Am J Med Genet A. 146A(24):3173-80, 2008
                                              10. Picone O et al: Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection. Prenat Diagn. 28(8):753-8, 2008
                                              11. Ancora G et al: Cranial ultrasound scanning and prediction of outcome in newborns with congenital cytomegalovirus infection. J Pediatr. 150(2):157-61, 2007
                                              12. Malm G et al: Congenital cytomegalovirus infections. Semin Fetal Neonatal Med. 12(3):154-9, 2007
                                              13. de Vries LS et al: The spectrum of cranial ultrasound and magnetic resonance imaging abnormalities in congenital cytomegalovirus infection. Neuropediatrics. 35(2):113-9, 2004
                                              14. van der Knaap MS et al: Pattern of white matter abnormalities at MR imaging: use of polymerase chain reaction testing of Guthrie cards to link pattern with congenital cytomegalovirus infection. Radiology. 230(2):529-36, 2004
                                              15. Modlin JF et al: Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-2003. A newborn boy with petechiae and thrombocytopenia. N Engl J Med. 349(7):691-700, 2003
                                              16. Bale JF Jr: Congenital infections. Neurol Clin. 20(4):1039-60, vii, 2002
                                              17. Wright R et al: Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection. Pediatrics. 100(1):E9, 1997
                                              18. Barkovich AJ et al: Congenital cytomegalovirus infection of the brain: imaging analysis and embryologic considerations. AJNR Am J Neuroradiol. 15(4):703-15, 1994
                                              19. Boesch C et al: Magnetic resonance imaging of the brain in congenital cytomegalovirus infection. Pediatr Radiol. 19(2):91-3, 1989
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Congenital cytomegalovirus (CMV)
                                                        • Synonyms

                                                          • Human cytomegalovirus (HCMV)
                                                        • Definitions

                                                          • Congenital infection caused by transplacental transmission of CMV, a member of herpes virus family
                                                            • Most common source of intrauterine infection in USA

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Capretti MG et al: Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection. Brain Dev. 36(3):203-11, 2014
                                                                                          2. Alarcon A et al: Clinical, biochemical, and neuroimaging findings predict long-term neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr. 163(3):828-34, 2013
                                                                                          3. Fink KR et al: Neuroimaging of pediatric central nervous system cytomegalovirus infection. Radiographics. 30(7):1779-96, 2010
                                                                                          4. Lanari M et al: Neuroimaging in CMV congenital infected neonates: how and when. Early Hum Dev. 88 Suppl 2:S3-5, 2012
                                                                                          5. Manara R et al: Brain magnetic resonance findings in symptomatic congenital cytomegalovirus infection. Pediatr Radiol. 41(8):962-70, 2011
                                                                                          6. Malinger G et al: Imaging of fetal cytomegalovirus infection. Fetal Diagn Ther. 29(2):117-26, 2011
                                                                                          7. O'Driscoll MC et al: Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria. Am J Hum Genet. 87(3):354-64, 2010
                                                                                          8. Benoist G et al: Cytomegalovirus-related fetal brain lesions: comparison between targeted ultrasound examination and magnetic resonance imaging. Ultrasound Obstet Gynecol. 32(7):900-5, 2008
                                                                                          9. Briggs TA et al: Band-like intracranial calcification with simplified gyration and polymicrogyria: a distinct "pseudo-TORCH" phenotype. Am J Med Genet A. 146A(24):3173-80, 2008
                                                                                          10. Picone O et al: Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection. Prenat Diagn. 28(8):753-8, 2008
                                                                                          11. Ancora G et al: Cranial ultrasound scanning and prediction of outcome in newborns with congenital cytomegalovirus infection. J Pediatr. 150(2):157-61, 2007
                                                                                          12. Malm G et al: Congenital cytomegalovirus infections. Semin Fetal Neonatal Med. 12(3):154-9, 2007
                                                                                          13. de Vries LS et al: The spectrum of cranial ultrasound and magnetic resonance imaging abnormalities in congenital cytomegalovirus infection. Neuropediatrics. 35(2):113-9, 2004
                                                                                          14. van der Knaap MS et al: Pattern of white matter abnormalities at MR imaging: use of polymerase chain reaction testing of Guthrie cards to link pattern with congenital cytomegalovirus infection. Radiology. 230(2):529-36, 2004
                                                                                          15. Modlin JF et al: Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-2003. A newborn boy with petechiae and thrombocytopenia. N Engl J Med. 349(7):691-700, 2003
                                                                                          16. Bale JF Jr: Congenital infections. Neurol Clin. 20(4):1039-60, vii, 2002
                                                                                          17. Wright R et al: Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection. Pediatrics. 100(1):E9, 1997
                                                                                          18. Barkovich AJ et al: Congenital cytomegalovirus infection of the brain: imaging analysis and embryologic considerations. AJNR Am J Neuroradiol. 15(4):703-15, 1994
                                                                                          19. Boesch C et al: Magnetic resonance imaging of the brain in congenital cytomegalovirus infection. Pediatr Radiol. 19(2):91-3, 1989