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Constrictive Bronchiolitis
Tomás Franquet, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Constrictive bronchiolitis (CB)
                • Bronchiolitis obliterans syndrome (BOS)
              • Synonyms

                • Bronchiolitis obliterans
                • Obliterative bronchiolitis
              • Definitions

                • Specific pattern of pulmonary response to diverse injuries; may be idiopathic
                  • Submucosal and peribronchiolar fibrosis with bronchiolar narrowing or luminal obliteration
                    • Concentric fibrosis of bronchiolar wall
                      • Between bronchiolar epithelium and muscularis mucosa
                    • Bronchiolar narrowing &/or obliteration
                      • Absence of intraluminal granulation tissue polyps
                      • No surrounding parenchymal inflammation

              IMAGING

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Histologic Features

                        CLINICAL ISSUES

                        • Presentation

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Clinically Relevant Pathologic Features

                                • Pathologic Interpretation Pearls

                                  Selected References

                                  1. Kligerman SJ et al: Mosaic attenuation: etiology, methods of differentiation, and pitfalls. Radiographics. 35(5):1360-80, 2015
                                  2. Abbott GF et al: Imaging of small airways disease. J Thorac Imaging. 24(4):285-98, 2009
                                  3. Chen CZ et al: Small airways obstruction syndrome in clinical practice. Respirology. 14(3):393-8, 2009
                                  4. Pipavath SJ, Lynch DA, Cool C, Brown KK, Newell JD. Radiologic and pathologic features of bronchiolitis. AJR Am J Roentgenol. 2005 Aug;185(2):354-63.
                                  5. Couture C et al: Histopathology of bronchiolar disorders. Semin Respir Crit Care Med. 24(5):489-98, 2003
                                  6. Ryu JH et al: Bronchiolar disorders. Am J Respir Crit Care Med. 168(11):1277-92, 2003
                                  7. Colby TV: Bronchiolitis, pathologic considerations. M J Clin Pathol 1998;109:101-109.
                                  8. Müller NL et al: Diseases of the bronchioles: CT and histopathologic findings. Radiology. 196(1):3-12, 1995
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Constrictive bronchiolitis (CB)
                                                • Bronchiolitis obliterans syndrome (BOS)
                                              • Synonyms

                                                • Bronchiolitis obliterans
                                                • Obliterative bronchiolitis
                                              • Definitions

                                                • Specific pattern of pulmonary response to diverse injuries; may be idiopathic
                                                  • Submucosal and peribronchiolar fibrosis with bronchiolar narrowing or luminal obliteration
                                                    • Concentric fibrosis of bronchiolar wall
                                                      • Between bronchiolar epithelium and muscularis mucosa
                                                    • Bronchiolar narrowing &/or obliteration
                                                      • Absence of intraluminal granulation tissue polyps
                                                      • No surrounding parenchymal inflammation

                                              IMAGING

                                              • Radiographic Findings

                                                • CT Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • Histologic Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Clinically Relevant Pathologic Features

                                                                • Pathologic Interpretation Pearls

                                                                  Selected References

                                                                  1. Kligerman SJ et al: Mosaic attenuation: etiology, methods of differentiation, and pitfalls. Radiographics. 35(5):1360-80, 2015
                                                                  2. Abbott GF et al: Imaging of small airways disease. J Thorac Imaging. 24(4):285-98, 2009
                                                                  3. Chen CZ et al: Small airways obstruction syndrome in clinical practice. Respirology. 14(3):393-8, 2009
                                                                  4. Pipavath SJ, Lynch DA, Cool C, Brown KK, Newell JD. Radiologic and pathologic features of bronchiolitis. AJR Am J Roentgenol. 2005 Aug;185(2):354-63.
                                                                  5. Couture C et al: Histopathology of bronchiolar disorders. Semin Respir Crit Care Med. 24(5):489-98, 2003
                                                                  6. Ryu JH et al: Bronchiolar disorders. Am J Respir Crit Care Med. 168(11):1277-92, 2003
                                                                  7. Colby TV: Bronchiolitis, pathologic considerations. M J Clin Pathol 1998;109:101-109.
                                                                  8. Müller NL et al: Diseases of the bronchioles: CT and histopathologic findings. Radiology. 196(1):3-12, 1995