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KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Contralateral breast cancer (CBC)
Definitions
Synchronous contralateral breast cancer (SCBC): Defined variably as simultaneous, within 3 months, or within 1 year of incident tumor diagnosis; nearly always 2nd primary BC
Metachronous contralateral breast cancer (MCBC): 2nd primary cancer diagnosed after incident tumor treatment; range from > 3 months to many years following initial breast cancer diagnosis/treatment
Histopathology includes invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), ductal carcinoma in situ (DCIS), and pleomorphic lobular carcinoma in situ (PLCIS)
Breast-conserving treatment (BCT): Breast-conserving surgery (BCS) followed by adjuvant radiation therapy (XRT)
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Kim SY et al: Breast cancer detected at screening US: survival rates and clinical-pathologic and imaging factors associated with recurrence. Radiology. 284(2):354-64, 2017
Gierach GL et al: Association of adjuvant tamoxifen and aromatase inhibitor therapy with contralateral breast cancer risk among US women with breast cancer in a general community setting. JAMA Oncol. 3(2):186-193, 2017
Houssami N et al: Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer. Breast Cancer Res Treat. 165(2):273-283, 2017
Kuchenbaecker KB et al: Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 317(23):2402-2416, 2017
Marmor S et al: Prognostic factors for metachronous contralateral breast cancer: implications for management of the contralateral breast. Breast J. 23(3):299-306, 2017
Raghavendra A et al: Mammographic breast density is associated with the development of contralateral breast cancer. Cancer. 123(11):1935-1940, 2017
Reiner AS et al: Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population. Breast Cancer Res. 19(1):83, 2017
Robson ME et al: Association of common genetic variants with contralateral breast cancer risk in the WECARE study. J Natl Cancer Inst. 109(10), 2017
Langballe R et al: Systemic therapy for breast cancer and risk of subsequent contralateral breast cancer in the WECARE study. Breast Cancer Res. 18(1):65, 2016
Kim JY et al: Unilateral breast cancer: screening of contralateral breast by using preoperative MR imaging reduces incidence of metachronous cancer. Radiology. 267(1):57-66, 2013
Berg WA et al: Comparative effectiveness of positron emission mammography and MRI in the contralateral breast of women with newly diagnosed breast cancer. AJR Am J Roentgenol. 198(1):219-32, 2012
Plana MN et al: Magnetic resonance imaging in the preoperative assessment of patients with primary breast cancer: systematic review of diagnostic accuracy and meta-analysis. Eur Radiol. 22(1):26-38, 2012
Saltzman BS et al: Estrogen receptor, progesterone receptor, and HER2-neu expression in first primary breast cancers and risk of second primary contralateral breast cancer. Breast Cancer Res Treat. 135(3):849-55, 2012
Alkner S et al: Prediction of outcome after diagnosis of metachronous contralateral breast cancer. BMC Cancer. 11:114, 2011
Houssami N et al: Accuracy and outcomes of screening mammography in women with a personal history of early-stage breast cancer. JAMA. 305(8):790-9, 2011
Metcalfe K et al: Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Br J Cancer. 104(9):1384-92, 2011
Morrow M et al: MRI for breast cancer screening, diagnosis, and treatment. Lancet. 378(9805):1804-11, 2011
Vichapat V et al: Prognosis of metachronous contralateral breast cancer: importance of stage, age and interval time between the two diagnoses. Breast Cancer Res Treat. 130(2):609-18, 2011
Brem RF et al: Detection of occult foci of breast cancer using breast-specific gamma imaging in women with one mammographic or clinically suspicious breast lesion. Acad Radiol. 17(6):735-43, 2010
Cuzick J et al: Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol. 11(12):1135-41, 2010
Brennan ME et al: Magnetic resonance imaging screening of the contralateral breast in women with newly diagnosed breast cancer: systematic review and meta-analysis of incremental cancer detection and impact on surgical management. J Clin Oncol. 27(33):5640-9, 2009
Li CI et al: Adjuvant hormonal therapy for breast cancer and risk of hormone receptor-specific subtypes of contralateral breast cancer. Cancer Res. 69(17):6865-70, 2009
Sorbero ME et al: Diagnostic breast magnetic resonance imaging and contralateral prophylactic mastectomy. Ann Surg Oncol. 16(6):1597-605, 2009
Kim SJ et al: Application of sonographic BI-RADS to synchronous breast nodules detected in patients with breast cancer. AJR Am J Roentgenol. 191(3):653-8, 2008
Lehman CD et al: MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med. 356(13):1295-303, 2007
Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 365(9472):1687-717, 2005
Gilroy JS et al: Breast-conserving therapy in patients with bilateral breast cancer: do today's treatment choices burn bridges for tomorrow? Int J Radiat Oncol Biol Phys. 62(2):379-85, 2005
Kahla PB et al: Bilateral synchronous breast cancer in a male. Mt Sinai J Med. 72(2):120-3, 2005
Lehman CD et al: Added cancer yield of MRI in screening the contralateral breast of women recently diagnosed with breast cancer: results from the International Breast Magnetic Resonance Consortium (IBMC) trial. J Surg Oncol. 92(1):9-15; discussion 15-6, 2005
Pediconi F et al: CE-Magnetic Resonance Mammography for the evaluation of the contralateral breast in patients with diagnosed breast cancer. Radiol Med (Torino). 110(1-2):61-8, 2005
Stolier AJ et al: Newly diagnosed breast cancer patients choose bilateral mastectomy over breast-conserving surgery when testing positive for a BRCA1/2 mutation. Am Surg. 71(12):1031-3, 2005
Yamauchi C et al: Bilateral breast-conserving therapy for bilateral breast cancer: results and consideration of radiation technique. Breast Cancer. 12(2):135-9, 2005
Berg WA et al: Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. Radiology. 233(3):830-49, 2004
Horwich A et al: Second primary breast cancer after Hodgkin's disease. Br J Cancer. 90(2):294-8, 2004
Intra M et al: Clinicopathologic characteristics of 143 patients with synchronous bilateral invasive breast carcinomas treated in a single institution. Cancer. 101(5):905-12, 2004
Lee SG et al: MR imaging screening of the contralateral breast in patients with newly diagnosed breast cancer: preliminary results. Radiology. 226(3):773-8, 2003
Liberman L et al: MR imaging findings in the contralateral breast of women with recently diagnosed breast cancer. AJR Am J Roentgenol. 180(2):333-41, 2003
Moon WK et al: Multifocal, multicentric, and contralateral breast cancers: bilateral whole-breast US in the preoperative evaluation of patients. Radiology. 224(2):569-76, 2002
Brown H et al: Histopathologic features of bilateral and unilateral breast carcinoma: a comparative study. Mod Pathol 13:18A, 2000
Fisher B et al: Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 90(18):1371-88, 1998
Fischer U et al: Prognostic value of contrast-enhanced MR mammography in patients with breast cancer. Eur Radiol. 7(7):1002-5, 1997
Roubidoux MA et al: Women with breast cancer: histologic findings in the contralateral breast. Radiology. 203(3):691-4, 1997
Murphy TJ et al: Bilateral breast carcinoma: mammographic and histologic correlation. Radiology. 195(3):617-21, 1995
Roubidoux MA et al: Bilateral breast cancer: early detection with mammography. Radiology. 196(2):427-31, 1995
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Contralateral breast cancer (CBC)
Definitions
Synchronous contralateral breast cancer (SCBC): Defined variably as simultaneous, within 3 months, or within 1 year of incident tumor diagnosis; nearly always 2nd primary BC
Metachronous contralateral breast cancer (MCBC): 2nd primary cancer diagnosed after incident tumor treatment; range from > 3 months to many years following initial breast cancer diagnosis/treatment
Histopathology includes invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), ductal carcinoma in situ (DCIS), and pleomorphic lobular carcinoma in situ (PLCIS)
Breast-conserving treatment (BCT): Breast-conserving surgery (BCS) followed by adjuvant radiation therapy (XRT)
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Kim SY et al: Breast cancer detected at screening US: survival rates and clinical-pathologic and imaging factors associated with recurrence. Radiology. 284(2):354-64, 2017
Gierach GL et al: Association of adjuvant tamoxifen and aromatase inhibitor therapy with contralateral breast cancer risk among US women with breast cancer in a general community setting. JAMA Oncol. 3(2):186-193, 2017
Houssami N et al: Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer. Breast Cancer Res Treat. 165(2):273-283, 2017
Kuchenbaecker KB et al: Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 317(23):2402-2416, 2017
Marmor S et al: Prognostic factors for metachronous contralateral breast cancer: implications for management of the contralateral breast. Breast J. 23(3):299-306, 2017
Raghavendra A et al: Mammographic breast density is associated with the development of contralateral breast cancer. Cancer. 123(11):1935-1940, 2017
Reiner AS et al: Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population. Breast Cancer Res. 19(1):83, 2017
Robson ME et al: Association of common genetic variants with contralateral breast cancer risk in the WECARE study. J Natl Cancer Inst. 109(10), 2017
Langballe R et al: Systemic therapy for breast cancer and risk of subsequent contralateral breast cancer in the WECARE study. Breast Cancer Res. 18(1):65, 2016
Kim JY et al: Unilateral breast cancer: screening of contralateral breast by using preoperative MR imaging reduces incidence of metachronous cancer. Radiology. 267(1):57-66, 2013
Berg WA et al: Comparative effectiveness of positron emission mammography and MRI in the contralateral breast of women with newly diagnosed breast cancer. AJR Am J Roentgenol. 198(1):219-32, 2012
Plana MN et al: Magnetic resonance imaging in the preoperative assessment of patients with primary breast cancer: systematic review of diagnostic accuracy and meta-analysis. Eur Radiol. 22(1):26-38, 2012
Saltzman BS et al: Estrogen receptor, progesterone receptor, and HER2-neu expression in first primary breast cancers and risk of second primary contralateral breast cancer. Breast Cancer Res Treat. 135(3):849-55, 2012
Alkner S et al: Prediction of outcome after diagnosis of metachronous contralateral breast cancer. BMC Cancer. 11:114, 2011
Houssami N et al: Accuracy and outcomes of screening mammography in women with a personal history of early-stage breast cancer. JAMA. 305(8):790-9, 2011
Metcalfe K et al: Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Br J Cancer. 104(9):1384-92, 2011
Morrow M et al: MRI for breast cancer screening, diagnosis, and treatment. Lancet. 378(9805):1804-11, 2011
Vichapat V et al: Prognosis of metachronous contralateral breast cancer: importance of stage, age and interval time between the two diagnoses. Breast Cancer Res Treat. 130(2):609-18, 2011
Brem RF et al: Detection of occult foci of breast cancer using breast-specific gamma imaging in women with one mammographic or clinically suspicious breast lesion. Acad Radiol. 17(6):735-43, 2010
Cuzick J et al: Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol. 11(12):1135-41, 2010
Brennan ME et al: Magnetic resonance imaging screening of the contralateral breast in women with newly diagnosed breast cancer: systematic review and meta-analysis of incremental cancer detection and impact on surgical management. J Clin Oncol. 27(33):5640-9, 2009
Li CI et al: Adjuvant hormonal therapy for breast cancer and risk of hormone receptor-specific subtypes of contralateral breast cancer. Cancer Res. 69(17):6865-70, 2009
Sorbero ME et al: Diagnostic breast magnetic resonance imaging and contralateral prophylactic mastectomy. Ann Surg Oncol. 16(6):1597-605, 2009
Kim SJ et al: Application of sonographic BI-RADS to synchronous breast nodules detected in patients with breast cancer. AJR Am J Roentgenol. 191(3):653-8, 2008
Lehman CD et al: MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med. 356(13):1295-303, 2007
Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 365(9472):1687-717, 2005
Gilroy JS et al: Breast-conserving therapy in patients with bilateral breast cancer: do today's treatment choices burn bridges for tomorrow? Int J Radiat Oncol Biol Phys. 62(2):379-85, 2005
Kahla PB et al: Bilateral synchronous breast cancer in a male. Mt Sinai J Med. 72(2):120-3, 2005
Lehman CD et al: Added cancer yield of MRI in screening the contralateral breast of women recently diagnosed with breast cancer: results from the International Breast Magnetic Resonance Consortium (IBMC) trial. J Surg Oncol. 92(1):9-15; discussion 15-6, 2005
Pediconi F et al: CE-Magnetic Resonance Mammography for the evaluation of the contralateral breast in patients with diagnosed breast cancer. Radiol Med (Torino). 110(1-2):61-8, 2005
Stolier AJ et al: Newly diagnosed breast cancer patients choose bilateral mastectomy over breast-conserving surgery when testing positive for a BRCA1/2 mutation. Am Surg. 71(12):1031-3, 2005
Yamauchi C et al: Bilateral breast-conserving therapy for bilateral breast cancer: results and consideration of radiation technique. Breast Cancer. 12(2):135-9, 2005
Berg WA et al: Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. Radiology. 233(3):830-49, 2004
Horwich A et al: Second primary breast cancer after Hodgkin's disease. Br J Cancer. 90(2):294-8, 2004
Intra M et al: Clinicopathologic characteristics of 143 patients with synchronous bilateral invasive breast carcinomas treated in a single institution. Cancer. 101(5):905-12, 2004
Lee SG et al: MR imaging screening of the contralateral breast in patients with newly diagnosed breast cancer: preliminary results. Radiology. 226(3):773-8, 2003
Liberman L et al: MR imaging findings in the contralateral breast of women with recently diagnosed breast cancer. AJR Am J Roentgenol. 180(2):333-41, 2003
Moon WK et al: Multifocal, multicentric, and contralateral breast cancers: bilateral whole-breast US in the preoperative evaluation of patients. Radiology. 224(2):569-76, 2002
Brown H et al: Histopathologic features of bilateral and unilateral breast carcinoma: a comparative study. Mod Pathol 13:18A, 2000
Fisher B et al: Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 90(18):1371-88, 1998
Fischer U et al: Prognostic value of contrast-enhanced MR mammography in patients with breast cancer. Eur Radiol. 7(7):1002-5, 1997
Roubidoux MA et al: Women with breast cancer: histologic findings in the contralateral breast. Radiology. 203(3):691-4, 1997
Murphy TJ et al: Bilateral breast carcinoma: mammographic and histologic correlation. Radiology. 195(3):617-21, 1995
Roubidoux MA et al: Bilateral breast cancer: early detection with mammography. Radiology. 196(2):427-31, 1995
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