Corticodentatonigral degeneration with neuronal achromasia
Definitions
Progressive neurodegenerative disease
Presents with cognitive dysfunction & progressive "asymmetrical" parkinsonism
Characterized pathologically by cortical & striatal tau protein accumulation (tauopathy)
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Fabbrini G et al: Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration. Handb Clin Neurol. 165:155-77, 2019
Saranza GM et al: Corticobasal degeneration. Int Rev Neurobiol. 149:87-136, 2019
Ali F et al: Corticobasal degeneration: key emerging issues. J Neurol. 265(2):439-45, 2018
Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 2. AJNR Am J Neuroradiol. 36(2):236-44, 2015
Josephs KA: Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. J Neurol. 262(3):783-8, 2015
Shimohata T et al: [Criteria for the diagnosis of corticobasal degeneration.] Brain Nerve. 67(4):513-23, 2015
Grijalvo-Perez AM et al: Corticobasal degeneration. Semin Neurol. 34(2):160-73, 2014
Shimohata T et al: [Clinical aspects of corticobasal syndrome.] Brain Nerve. 65(1):31-40, 2013
Erbetta A et al: Diffusion tensor imaging shows different topographic involvement of the thalamus in progressive supranuclear palsy and corticobasal degeneration. AJNR Am J Neuroradiol. 30(8):1482-7, 2009
Vitali P et al: Neuroimaging in dementia. Semin Neurol. 28(4):467-83, 2008
Koyama M et al: Imaging of corticobasal degeneration syndrome. Neuroradiology. 49(11):905-12, 2007
Klaffke S et al: Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration. Mov Disord. 21(10):1724-7, 2006
Mahapatra RK et al: Corticobasal degeneration. Lancet Neurol. 3(12):736-43, 2004
Laureys S et al: Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration. J Neurol. 246(12):1151-8, 1999
Hauser RA et al: Magnetic resonance imaging of corticobasal degeneration. J Neuroimaging. 6(4):222-6, 1996
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Corticobasal degeneration (CBD)
Synonyms
Corticobasal ganglionic degeneration (CBGD)
Corticodentatonigral degeneration with neuronal achromasia
Definitions
Progressive neurodegenerative disease
Presents with cognitive dysfunction & progressive "asymmetrical" parkinsonism
Characterized pathologically by cortical & striatal tau protein accumulation (tauopathy)
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Fabbrini G et al: Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration. Handb Clin Neurol. 165:155-77, 2019
Saranza GM et al: Corticobasal degeneration. Int Rev Neurobiol. 149:87-136, 2019
Ali F et al: Corticobasal degeneration: key emerging issues. J Neurol. 265(2):439-45, 2018
Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 2. AJNR Am J Neuroradiol. 36(2):236-44, 2015
Josephs KA: Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. J Neurol. 262(3):783-8, 2015
Shimohata T et al: [Criteria for the diagnosis of corticobasal degeneration.] Brain Nerve. 67(4):513-23, 2015
Grijalvo-Perez AM et al: Corticobasal degeneration. Semin Neurol. 34(2):160-73, 2014
Shimohata T et al: [Clinical aspects of corticobasal syndrome.] Brain Nerve. 65(1):31-40, 2013
Erbetta A et al: Diffusion tensor imaging shows different topographic involvement of the thalamus in progressive supranuclear palsy and corticobasal degeneration. AJNR Am J Neuroradiol. 30(8):1482-7, 2009
Vitali P et al: Neuroimaging in dementia. Semin Neurol. 28(4):467-83, 2008
Koyama M et al: Imaging of corticobasal degeneration syndrome. Neuroradiology. 49(11):905-12, 2007
Klaffke S et al: Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration. Mov Disord. 21(10):1724-7, 2006
Mahapatra RK et al: Corticobasal degeneration. Lancet Neurol. 3(12):736-43, 2004
Laureys S et al: Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration. J Neurol. 246(12):1151-8, 1999
Hauser RA et al: Magnetic resonance imaging of corticobasal degeneration. J Neuroimaging. 6(4):222-6, 1996
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