link
Bookmarks
CPA-IAC Superficial Siderosis
H. Ric Harnsberger, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
11
6
2

KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        TERMINOLOGY

        • Abbreviations

          • Superficial siderosis (SS)
        • Synonyms

          • Siderosis, central nervous system siderosis
        • Definitions

          • Recurrent subarachnoid hemorrhage (SAH) causes hemosiderin deposition on surface of brain, brainstem, and cranial nerve leptomeninges

        IMAGING

        • General Features

          • CT Findings

            • MR Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Gross Pathologic & Surgical Features

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                DIAGNOSTIC CHECKLIST

                                • Consider

                                  • Image Interpretation Pearls

                                    • Reporting Tips

                                      Selected References

                                      1. Charidimou A et al: Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. Brain. 138(Pt 8):2126-39, 2015
                                      2. Kishimoto I et al: Clinical features of rapidly progressive bilateral sensorineural hearing loss. Acta Otolaryngol. 134(1):58-65, 2014
                                      3. Tyler GK et al: Systematic review of outcome of cochlear implantation in superficial siderosis. Otol Neurotol. 33(6):976-82, 2012
                                      4. Nadol JB Jr et al: Temporal bone histopathology in a case of sensorineural hearing loss caused by superficial siderosis of the central nervous system and treated by cochlear implantation. Otol Neurotol. 32(5):748-55, 2011
                                      5. Linn J et al: Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology. 74(17):1346-50, 2010
                                      6. Koeppen AH et al: The pathology of superficial siderosis of the central nervous system. Acta Neuropathol. 116(4):371-82, 2008
                                      7. Kumar N: Superficial siderosis: associations and therapeutic implications. Arch Neurol. 64(4):491-6, 2007
                                      8. Kumar N et al: Superficial siderosis. Neurology. 66(8):1144-52, 2006
                                      9. Leussink VI et al: Superficial siderosis of the central nervous system: pathogenetic heterogeneity and therapeutic approaches. Acta Neurol Scand. 107(1):54-61, 2003
                                      10. Dhooge IJ et al: Cochlear implantation in a patient with superficial siderosis of the central nervous system. Otol Neurotol. 23(4):468-72, 2002
                                      11. Hsu WC et al: Superficial siderosis of the CNS associated with multiple cavernous malformations. AJNR Am J Neuroradiol. 20(7):1245-8, 1999
                                      12. Weller M et al: Elevated CSF lactoferrin in superficial siderosis of the central nervous system. J Neurol. 246(10):943-5, 1999
                                      13. Lemmerling M et al: Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. Neuroradiology. 40(5):312-4, 1998
                                      14. Castelli ML et al: Superficial siderosis of the central nervous system: an underestimated cause of hearing loss. J Laryngol Otol. 111(1):60-2, 1997
                                      15. Maurizi CP: Superficial siderosis of the brain: roles for cerebrospinal fluid circulation, iron and the hydroxyl radical. Med Hypotheses. 47(4):261-4, 1996
                                      16. Offenbacher H et al: Superficial siderosis of the central nervous system: MRI findings and clinical significance. Neuroradiology. 38 Suppl 1:S51-6, 1996
                                      17. Bracchi M et al: Superficial siderosis of the CNS: MR diagnosis and clinical findings. AJNR Am J Neuroradiol. 14(1):227-36, 1993
                                      Related Anatomy
                                      Loading...
                                      Related Differential Diagnoses
                                      Loading...
                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Superficial siderosis (SS)
                                            • Synonyms

                                              • Siderosis, central nervous system siderosis
                                            • Definitions

                                              • Recurrent subarachnoid hemorrhage (SAH) causes hemosiderin deposition on surface of brain, brainstem, and cranial nerve leptomeninges

                                            IMAGING

                                            • General Features

                                              • CT Findings

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      • Image Interpretation Pearls

                                                                        • Reporting Tips

                                                                          Selected References

                                                                          1. Charidimou A et al: Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. Brain. 138(Pt 8):2126-39, 2015
                                                                          2. Kishimoto I et al: Clinical features of rapidly progressive bilateral sensorineural hearing loss. Acta Otolaryngol. 134(1):58-65, 2014
                                                                          3. Tyler GK et al: Systematic review of outcome of cochlear implantation in superficial siderosis. Otol Neurotol. 33(6):976-82, 2012
                                                                          4. Nadol JB Jr et al: Temporal bone histopathology in a case of sensorineural hearing loss caused by superficial siderosis of the central nervous system and treated by cochlear implantation. Otol Neurotol. 32(5):748-55, 2011
                                                                          5. Linn J et al: Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology. 74(17):1346-50, 2010
                                                                          6. Koeppen AH et al: The pathology of superficial siderosis of the central nervous system. Acta Neuropathol. 116(4):371-82, 2008
                                                                          7. Kumar N: Superficial siderosis: associations and therapeutic implications. Arch Neurol. 64(4):491-6, 2007
                                                                          8. Kumar N et al: Superficial siderosis. Neurology. 66(8):1144-52, 2006
                                                                          9. Leussink VI et al: Superficial siderosis of the central nervous system: pathogenetic heterogeneity and therapeutic approaches. Acta Neurol Scand. 107(1):54-61, 2003
                                                                          10. Dhooge IJ et al: Cochlear implantation in a patient with superficial siderosis of the central nervous system. Otol Neurotol. 23(4):468-72, 2002
                                                                          11. Hsu WC et al: Superficial siderosis of the CNS associated with multiple cavernous malformations. AJNR Am J Neuroradiol. 20(7):1245-8, 1999
                                                                          12. Weller M et al: Elevated CSF lactoferrin in superficial siderosis of the central nervous system. J Neurol. 246(10):943-5, 1999
                                                                          13. Lemmerling M et al: Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. Neuroradiology. 40(5):312-4, 1998
                                                                          14. Castelli ML et al: Superficial siderosis of the central nervous system: an underestimated cause of hearing loss. J Laryngol Otol. 111(1):60-2, 1997
                                                                          15. Maurizi CP: Superficial siderosis of the brain: roles for cerebrospinal fluid circulation, iron and the hydroxyl radical. Med Hypotheses. 47(4):261-4, 1996
                                                                          16. Offenbacher H et al: Superficial siderosis of the central nervous system: MRI findings and clinical significance. Neuroradiology. 38 Suppl 1:S51-6, 1996
                                                                          17. Bracchi M et al: Superficial siderosis of the CNS: MR diagnosis and clinical findings. AJNR Am J Neuroradiol. 14(1):227-36, 1993