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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Calcium pyrophosphate dihydrate deposition (CPPD) disease
Definitions
- Pseudogout: Acute painful episode due to CPPD
- Terms with "pseudo" should generally be abandoned in favor of CPPD
- Crowned dens syndrome: Pain due to calcium pyrophosphate crystal deposition around dens
- Pseudogout: Acute painful episode due to CPPD
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Andrés M et al: Progresses in the imaging of calcium pyrophosphate crystal disease. Curr Opin Rheumatol. 32(2):140-5, 2020
- Joyce AA et al: Atlanto-axial pannus in patients with and without rheumatoid arthritis. J Rheumatol. 46(11):1431-7, 2019
- Andrés M et al: Therapy for CPPD: options and evidence. Curr Rheumatol Rep. 20(6):31, 2018
- Wold A et al: Non-union rate of type II and III odontoid fractures in CPPD versus a control population. Skeletal Radiol. 47(11):1499-504, 2018
- Ea HK et al: Diagnosis and clinical manifestations of calcium pyrophosphate and basic calcium phosphate crystal deposition diseases. Rheum Dis Clin North Am. 40(2):207-29, 2014
- Chang EY et al: Frequency of atlantoaxial calcium pyrophosphate dihydrate deposition at CT. Radiology. 269(2):519-24, 2013
- Tsui FW: Genetics and mechanisms of crystal deposition in calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 14(2):155-60, 2012
- Zhang W et al: European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis. Ann Rheum Dis. 70(4):563-70, 2011
- Roverano S et al: Calcification of the transverse ligament of the atlas in chondrocalcinosis. J Clin Rheumatol. 16(1):7-9, 2010
- Fenoy AJ et al: Calcium pyrophosphate dihydrate crystal deposition in the craniovertebral junction. J Neurosurg Spine. 8(1):22-9, 2008
- Finckh A et al: The cervical spine in calcium pyrophosphate dihydrate deposition disease. A prevalent case-control study. J Rheumatol. 31(3):545-9, 2004
- Chen CF et al: Calcium pyrophosphate dihydrate crystal deposition disease in cervical radiculomyelopathy. J Chin Med Assoc. 66(4):256-9, 2003
- Muthukumar N et al: Tumoral calcium pyrophosphate dihydrate deposition disease of the ligamentum flavum. Neurosurgery. 53(1):103-8; discussion 108-9, 2003
- Fujishiro T et al: Pseudogout attack of the lumbar facet joint: a case report. Spine. 27(17):E396-8, 2002
- Steinbach LS et al: Calcium pyrophosphate dihydrate crystal deposition disease: imaging perspectives. Curr Probl Diagn Radiol. 29(6):209-29, 2000
- Berlemann U et al: Calcium pyrophosphate dihydrate deposition in degenerate lumbar discs. Eur Spine J. 7(1):45-9, 1998
- Markiewitz AD et al: Calcium pyrophosphate dihydrate crystal deposition disease as a cause of lumbar canal stenosis. Spine. 21(4):506-11, 1996
- Brown TR et al: Deposition of calcium pyrophosphate dihydrate crystals in the ligamentum flavum: evaluation with MR imaging and CT. Radiology. 178(3):871-3, 1991
- el-Khoury GY et al: Massive calcium pyrophosphate crystal deposition at the craniovertebral junction. AJR Am J Roentgenol. 145(4):777-8, 1985
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Calcium pyrophosphate dihydrate deposition (CPPD) disease
Definitions
- Pseudogout: Acute painful episode due to CPPD
- Terms with "pseudo" should generally be abandoned in favor of CPPD
- Crowned dens syndrome: Pain due to calcium pyrophosphate crystal deposition around dens
- Pseudogout: Acute painful episode due to CPPD
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Andrés M et al: Progresses in the imaging of calcium pyrophosphate crystal disease. Curr Opin Rheumatol. 32(2):140-5, 2020
- Joyce AA et al: Atlanto-axial pannus in patients with and without rheumatoid arthritis. J Rheumatol. 46(11):1431-7, 2019
- Andrés M et al: Therapy for CPPD: options and evidence. Curr Rheumatol Rep. 20(6):31, 2018
- Wold A et al: Non-union rate of type II and III odontoid fractures in CPPD versus a control population. Skeletal Radiol. 47(11):1499-504, 2018
- Ea HK et al: Diagnosis and clinical manifestations of calcium pyrophosphate and basic calcium phosphate crystal deposition diseases. Rheum Dis Clin North Am. 40(2):207-29, 2014
- Chang EY et al: Frequency of atlantoaxial calcium pyrophosphate dihydrate deposition at CT. Radiology. 269(2):519-24, 2013
- Tsui FW: Genetics and mechanisms of crystal deposition in calcium pyrophosphate deposition disease. Curr Rheumatol Rep. 14(2):155-60, 2012
- Zhang W et al: European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis. Ann Rheum Dis. 70(4):563-70, 2011
- Roverano S et al: Calcification of the transverse ligament of the atlas in chondrocalcinosis. J Clin Rheumatol. 16(1):7-9, 2010
- Fenoy AJ et al: Calcium pyrophosphate dihydrate crystal deposition in the craniovertebral junction. J Neurosurg Spine. 8(1):22-9, 2008
- Finckh A et al: The cervical spine in calcium pyrophosphate dihydrate deposition disease. A prevalent case-control study. J Rheumatol. 31(3):545-9, 2004
- Chen CF et al: Calcium pyrophosphate dihydrate crystal deposition disease in cervical radiculomyelopathy. J Chin Med Assoc. 66(4):256-9, 2003
- Muthukumar N et al: Tumoral calcium pyrophosphate dihydrate deposition disease of the ligamentum flavum. Neurosurgery. 53(1):103-8; discussion 108-9, 2003
- Fujishiro T et al: Pseudogout attack of the lumbar facet joint: a case report. Spine. 27(17):E396-8, 2002
- Steinbach LS et al: Calcium pyrophosphate dihydrate crystal deposition disease: imaging perspectives. Curr Probl Diagn Radiol. 29(6):209-29, 2000
- Berlemann U et al: Calcium pyrophosphate dihydrate deposition in degenerate lumbar discs. Eur Spine J. 7(1):45-9, 1998
- Markiewitz AD et al: Calcium pyrophosphate dihydrate crystal deposition disease as a cause of lumbar canal stenosis. Spine. 21(4):506-11, 1996
- Brown TR et al: Deposition of calcium pyrophosphate dihydrate crystals in the ligamentum flavum: evaluation with MR imaging and CT. Radiology. 178(3):871-3, 1991
- el-Khoury GY et al: Massive calcium pyrophosphate crystal deposition at the craniovertebral junction. AJR Am J Roentgenol. 145(4):777-8, 1985
