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Craniopharyngioma
Luke L. Linscott, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Craniopharyngeal duct tumor, Rathke pouch tumor, adamantinoma
            • Definitions

              • Craniopharyngioma (CP): Histologically benign epithelial tumor arising from squamous rests along involuted hypophyseal-Rathke duct

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Müller HL: Preoperative staging in childhood craniopharyngioma: standardization as a first step towards improved outcome. Endocrine. 51(1):1-3, 2016
                                        2. Martinez-Barbera JP: Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. Neuropathol Appl Neurobiol. 41(6):721-32, 2015
                                        3. Steinbok P: Craniopharyngioma in children: long-term outcomes. Neurol Med Chir (Tokyo). 55(9):722-6, 2015
                                        4. Sterkenburg AS et al: Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes. Neuro Oncol. 17(7):1029-38, 2015
                                        5. Hussain I et al: Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. J Neurosurg. 119(1):106-12, 2013
                                        6. Plaza MJ et al: Conventional and advanced MRI features of pediatric intracranial tumors: posterior fossa and suprasellar tumors. AJR Am J Roentgenol. 200(5):1115-24, 2013
                                        7. Watanabe K et al: Delineation of optic nerves and chiasm in close proximity to large suprasellar tumors with contrast-enhanced FIESTA MR imaging. Radiology. 264(3):852-8, 2012
                                        8. Famini P et al: Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients. J Clin Endocrinol Metab. 96(6):1633-41, 2011
                                        9. Yamada S et al: Surgical outcome in 90 patients with craniopharyngioma: an evaluation of transsphenoidal surgery. World Neurosurg. 74(2-3):320-30, 2010
                                        10. Choi SH et al: Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI. Clin Radiol. 62(5):453-62, 2007
                                        11. Curran JG et al: Imaging of craniopharyngioma. Childs Nerv Syst. 21(8-9):635-9, 2005
                                        12. Tavangar SM et al: Craniopharyngioma: a clinicopathological study of 141 cases. Endocr Pathol. 15(4):339-44, 2004
                                        13. Brunel H et al: [Craniopharyngioma in children: MRI study of 43 cases.] Neurochirurgie. 48(4):309-18, 2002
                                        14. Sartoretti-Schefer S et al: MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. AJNR Am J Neuroradiol. 18(1):77-87, 1997
                                        15. Tsuda M et al: CT and MR imaging of craniopharyngioma. Eur Radiol. 7(4):464-9, 1997
                                        16. Eldevik OP et al: Craniopharyngioma: radiologic and histologic findings and recurrence. AJNR Am J Neuroradiol. 17(8):1427-39, 1996
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Craniopharyngeal duct tumor, Rathke pouch tumor, adamantinoma
                                                  • Definitions

                                                    • Craniopharyngioma (CP): Histologically benign epithelial tumor arising from squamous rests along involuted hypophyseal-Rathke duct

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Müller HL: Preoperative staging in childhood craniopharyngioma: standardization as a first step towards improved outcome. Endocrine. 51(1):1-3, 2016
                                                                              2. Martinez-Barbera JP: Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. Neuropathol Appl Neurobiol. 41(6):721-32, 2015
                                                                              3. Steinbok P: Craniopharyngioma in children: long-term outcomes. Neurol Med Chir (Tokyo). 55(9):722-6, 2015
                                                                              4. Sterkenburg AS et al: Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes. Neuro Oncol. 17(7):1029-38, 2015
                                                                              5. Hussain I et al: Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. J Neurosurg. 119(1):106-12, 2013
                                                                              6. Plaza MJ et al: Conventional and advanced MRI features of pediatric intracranial tumors: posterior fossa and suprasellar tumors. AJR Am J Roentgenol. 200(5):1115-24, 2013
                                                                              7. Watanabe K et al: Delineation of optic nerves and chiasm in close proximity to large suprasellar tumors with contrast-enhanced FIESTA MR imaging. Radiology. 264(3):852-8, 2012
                                                                              8. Famini P et al: Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients. J Clin Endocrinol Metab. 96(6):1633-41, 2011
                                                                              9. Yamada S et al: Surgical outcome in 90 patients with craniopharyngioma: an evaluation of transsphenoidal surgery. World Neurosurg. 74(2-3):320-30, 2010
                                                                              10. Choi SH et al: Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI. Clin Radiol. 62(5):453-62, 2007
                                                                              11. Curran JG et al: Imaging of craniopharyngioma. Childs Nerv Syst. 21(8-9):635-9, 2005
                                                                              12. Tavangar SM et al: Craniopharyngioma: a clinicopathological study of 141 cases. Endocr Pathol. 15(4):339-44, 2004
                                                                              13. Brunel H et al: [Craniopharyngioma in children: MRI study of 43 cases.] Neurochirurgie. 48(4):309-18, 2002
                                                                              14. Sartoretti-Schefer S et al: MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. AJNR Am J Neuroradiol. 18(1):77-87, 1997
                                                                              15. Tsuda M et al: CT and MR imaging of craniopharyngioma. Eur Radiol. 7(4):464-9, 1997
                                                                              16. Eldevik OP et al: Craniopharyngioma: radiologic and histologic findings and recurrence. AJNR Am J Neuroradiol. 17(8):1427-39, 1996