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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Cryptogenic organizing pneumonia (COP)
Synonyms
- Bronchiolitis obliterans organizing pneumonia (BOOP): Term no longer in use
- Idiopathic bronchiolitis obliterans organizing pneumonia: Term no longer in use
Definitions
- Idiopathic interstitial pneumonia
- 1.8-13% of all interstitial lung diseases
- Clinical pathological entity without known cause, histologically characterized by organizing pneumonia (OP)
- OP: Buds of granulation tissue (i.e., Masson bodies) within lumina of distal pulmonary airspaces
- Masson bodies: Fibroblasts and myofibroblasts intermixed with loose connective matrix
- OP may be idiopathic (COP), may occur as reaction to lung injury, or may be associated with other pulmonary conditions
- OP: Buds of granulation tissue (i.e., Masson bodies) within lumina of distal pulmonary airspaces
- Similar clinical and radiologic findings in patients with COP and secondary OP
- Idiopathic interstitial pneumonia
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Feinstein MB et al: A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia. J Clin Pathol. 68(6):441-7, 2015
- Mehrian P et al: The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. Pol J Radiol. 79:456-60, 2014
- Kligerman SJ et al: From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, organizing pneumonia, and acute fibrinous and organizing pneumonia. Radiographics. 33(7):1951-75, 2013
- Cottin V et al: Cryptogenic organizing pneumonia. Semin Respir Crit Care Med. 33(5):462-75, 2012
- Drakopanagiotakis F et al: Cryptogenic and secondary organizing pneumonia: clinical presentation, radiographic findings, treatment response, and prognosis. Chest. 139(4):893-900, 2011
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Cryptogenic organizing pneumonia (COP)
Synonyms
- Bronchiolitis obliterans organizing pneumonia (BOOP): Term no longer in use
- Idiopathic bronchiolitis obliterans organizing pneumonia: Term no longer in use
Definitions
- Idiopathic interstitial pneumonia
- 1.8-13% of all interstitial lung diseases
- Clinical pathological entity without known cause, histologically characterized by organizing pneumonia (OP)
- OP: Buds of granulation tissue (i.e., Masson bodies) within lumina of distal pulmonary airspaces
- Masson bodies: Fibroblasts and myofibroblasts intermixed with loose connective matrix
- OP may be idiopathic (COP), may occur as reaction to lung injury, or may be associated with other pulmonary conditions
- OP: Buds of granulation tissue (i.e., Masson bodies) within lumina of distal pulmonary airspaces
- Similar clinical and radiologic findings in patients with COP and secondary OP
- Idiopathic interstitial pneumonia
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Feinstein MB et al: A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia. J Clin Pathol. 68(6):441-7, 2015
- Mehrian P et al: The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. Pol J Radiol. 79:456-60, 2014
- Kligerman SJ et al: From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, organizing pneumonia, and acute fibrinous and organizing pneumonia. Radiographics. 33(7):1951-75, 2013
- Cottin V et al: Cryptogenic organizing pneumonia. Semin Respir Crit Care Med. 33(5):462-75, 2012
- Drakopanagiotakis F et al: Cryptogenic and secondary organizing pneumonia: clinical presentation, radiographic findings, treatment response, and prognosis. Chest. 139(4):893-900, 2011
