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Cryptogenic Organizing Pneumonia
Jorge Alberto Carrillo-Bayona, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Cryptogenic organizing pneumonia (COP)
              • Synonyms

                • Bronchiolitis obliterans organizing pneumonia (BOOP): Term no longer in use
                • Idiopathic bronchiolitis obliterans organizing pneumonia: Term no longer in use
              • Definitions

                • Idiopathic interstitial pneumonia
                  • 1.8-13% of all interstitial lung diseases
                • Clinical pathological entity without known cause, histologically characterized by organizing pneumonia (OP)
                  • OP: Buds of granulation tissue (i.e., Masson bodies) within lumina of distal pulmonary airspaces
                    • Masson bodies: Fibroblasts and myofibroblasts intermixed with loose connective matrix
                  • OP may be idiopathic (COP), may occur as reaction to lung injury, or may be associated with other pulmonary conditions
                • Similar clinical and radiologic findings in patients with COP and secondary OP

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Feinstein MB et al: A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia. J Clin Pathol. 68(6):441-7, 2015
                                      2. Mehrian P et al: The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. Pol J Radiol. 79:456-60, 2014
                                      3. Kligerman SJ et al: From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, organizing pneumonia, and acute fibrinous and organizing pneumonia. Radiographics. 33(7):1951-75, 2013
                                      4. Cottin V et al: Cryptogenic organizing pneumonia. Semin Respir Crit Care Med. 33(5):462-75, 2012
                                      5. Drakopanagiotakis F et al: Cryptogenic and secondary organizing pneumonia: clinical presentation, radiographic findings, treatment response, and prognosis. Chest. 139(4):893-900, 2011
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Cryptogenic organizing pneumonia (COP)
                                                  • Synonyms

                                                    • Bronchiolitis obliterans organizing pneumonia (BOOP): Term no longer in use
                                                    • Idiopathic bronchiolitis obliterans organizing pneumonia: Term no longer in use
                                                  • Definitions

                                                    • Idiopathic interstitial pneumonia
                                                      • 1.8-13% of all interstitial lung diseases
                                                    • Clinical pathological entity without known cause, histologically characterized by organizing pneumonia (OP)
                                                      • OP: Buds of granulation tissue (i.e., Masson bodies) within lumina of distal pulmonary airspaces
                                                        • Masson bodies: Fibroblasts and myofibroblasts intermixed with loose connective matrix
                                                      • OP may be idiopathic (COP), may occur as reaction to lung injury, or may be associated with other pulmonary conditions
                                                    • Similar clinical and radiologic findings in patients with COP and secondary OP

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • Nuclear Medicine Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Feinstein MB et al: A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia. J Clin Pathol. 68(6):441-7, 2015
                                                                          2. Mehrian P et al: The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. Pol J Radiol. 79:456-60, 2014
                                                                          3. Kligerman SJ et al: From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, organizing pneumonia, and acute fibrinous and organizing pneumonia. Radiographics. 33(7):1951-75, 2013
                                                                          4. Cottin V et al: Cryptogenic organizing pneumonia. Semin Respir Crit Care Med. 33(5):462-75, 2012
                                                                          5. Drakopanagiotakis F et al: Cryptogenic and secondary organizing pneumonia: clinical presentation, radiographic findings, treatment response, and prognosis. Chest. 139(4):893-900, 2011