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Cutaneous Squamous Cell Carcinoma
Nayela Keen, MD; Christine M. Glastonbury, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Cutaneous squamous cell carcinoma (cSCCa)
              • Synonyms

                • In situ cSCCa, known as Bowen disease
              • Definitions

                • Skin tumor arising from keratinocytes of epidermis (outer skin layer)

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Reporting Tips

                                              Selected References

                                              1. Ebrahimi A et al: Metastatic head and neck cutaneous squamous cell carcinoma: defining a low-risk patient. Head Neck. 34(3):365-70, 2012
                                              2. D'Souza J et al: Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg. 19(2):99-105, 2011
                                              3. Gurudutt VV et al: Cutaneous squamous cell carcinoma of the head and neck. J Skin Cancer. 2011:502723, 2011
                                              4. Niedernhofer LJ et al: Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients. Mech Ageing Dev. 132(6-7):340-7, 2011
                                              5. O'Hara J et al: Cutaneous squamous cell carcinoma of the head and neck metastasizing to the parotid gland--a review of current recommendations. Head Neck. 33(12):1789-95, 2011
                                              6. Wang JT et al: Predictors of outcome in patients with metastatic cutaneous head and neck squamous cell carcinoma involving cervical lymph nodes: Improved survival with the addition of adjuvant radiotherapy. Head Neck. Epub ahead of print, 2011
                                              7. Butt FM et al: Xeroderma pigmentosum: a review and case series. J Craniomaxillofac Surg. 38(7):534-7, 2010
                                              8. McGuire JF et al: Nonmelanoma skin cancer of the head and neck I: histopathology and clinical behavior. Am J Otolaryngol. 30(2):121-33, 2009
                                              9. Mendenhall WM et al: Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck. Laryngoscope. 119(10):1994-9, 2009
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Cutaneous squamous cell carcinoma (cSCCa)
                                                          • Synonyms

                                                            • In situ cSCCa, known as Bowen disease
                                                          • Definitions

                                                            • Skin tumor arising from keratinocytes of epidermis (outer skin layer)

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Ebrahimi A et al: Metastatic head and neck cutaneous squamous cell carcinoma: defining a low-risk patient. Head Neck. 34(3):365-70, 2012
                                                                                          2. D'Souza J et al: Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg. 19(2):99-105, 2011
                                                                                          3. Gurudutt VV et al: Cutaneous squamous cell carcinoma of the head and neck. J Skin Cancer. 2011:502723, 2011
                                                                                          4. Niedernhofer LJ et al: Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients. Mech Ageing Dev. 132(6-7):340-7, 2011
                                                                                          5. O'Hara J et al: Cutaneous squamous cell carcinoma of the head and neck metastasizing to the parotid gland--a review of current recommendations. Head Neck. 33(12):1789-95, 2011
                                                                                          6. Wang JT et al: Predictors of outcome in patients with metastatic cutaneous head and neck squamous cell carcinoma involving cervical lymph nodes: Improved survival with the addition of adjuvant radiotherapy. Head Neck. Epub ahead of print, 2011
                                                                                          7. Butt FM et al: Xeroderma pigmentosum: a review and case series. J Craniomaxillofac Surg. 38(7):534-7, 2010
                                                                                          8. McGuire JF et al: Nonmelanoma skin cancer of the head and neck I: histopathology and clinical behavior. Am J Otolaryngol. 30(2):121-33, 2009
                                                                                          9. Mendenhall WM et al: Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck. Laryngoscope. 119(10):1994-9, 2009