CMV pneumonia is serious cause of mortality and morbidity in immunocompromised adults
Patients with acquired immunodeficiency syndrome (AIDS)
Allogeneic stem cell transplant recipients
Solid organ transplant recipients
CMV pneumonia
Severe viral community-acquired pneumonia in immunocompetent adults
Proven CMV pneumonia requires clinical symptoms &/or signs of pneumonia
e.g., new airspace disease on imaging, hypoxia, tachypnea, &/or dyspnea
CMV documented in lung tissue
Virus isolation
Rapid culture
Histopathology
Immunohistochemistry
DNA hybridization techniques
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Kose A et al: Cytomegalovirus associated severe pneumonia in three liver transplant recipients. J Infect Dev Ctries. 14(11):1338-43, 2020
Kunihiro Y et al: Differential diagnosis of pulmonary infections in immunocompromised patients using high-resolution computed tomography. Eur Radiol. 29(11):6089-99, 2019
Restrepo-Gualteros SM et al: Challenges and clinical implications of the diagnosis of cytomegalovirus lung infection in children. Curr Infect Dis Rep. 21(7):24, 2019
Koo HJ et al: Radiographic and CT Features of viral pneumonia. Radiographics. 38(3):719-39, 2018
Shionoya Y et al: Cytomegalovirus pneumonia with progressive lung volume loss. Am J Case Rep. 19:1393-7, 2018
Almaghrabi RS et al: Cytomegalovirus infection in lung transplant recipients. Expert Rev Respir Med. 11(5):377-83, 2017
Ljungman P et al: Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials. Clin Infect Dis. 64(1):87-91, 2017
Kunihiro Y et al: The usefulness of a diagnostic method combining high-resolution CT findings and serum markers for cytomegalovirus pneumonia and pneumocystis pneumonia in non-AIDS patients. Acta Radiol. 56(7):806-13, 2015
Omeri AK et al: Comparison of high-resolution computed tomography findings between pseudomonas aeruginosa pneumonia and cytomegalovirus pneumonia. Eur Radiol. 24(12):3251-9, 2014
Cunha BA: Cytomegalovirus pneumonia: community-acquired pneumonia in immunocompetent hosts. Infect Dis Clin North Am. 24(1):147-58, 2010
Ison MG et al: Cytomegalovirus pneumonia in transplant recipients. Clin Chest Med. 26(4):691-705, viii, 2005
Chan KM et al: Infectious pulmonary complications in lung transplant recipients. Semin Respir Infect. 17(4):291-302, 2002
Kang EY et al: Cytomegalovirus pneumonia in transplant patients: CT findings. J Comput Assist Tomogr. 20(2):295-9, 1996
McGuinness G et al: Cytomegalovirus pneumonitis: spectrum of parenchymal CT findings with pathologic correlation in 21 AIDS patients. Radiology. 192(2):451-9, 1994
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
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TERMINOLOGY
Abbreviations
Cytomegalovirus (CMV)
Synonyms
Formerly known as human herpesvirus 5 (HHV-5)
Definitions
CMV
Member of herpesvirus family
Variety of disease manifestations
CMV pneumonia is serious cause of mortality and morbidity in immunocompromised adults
Patients with acquired immunodeficiency syndrome (AIDS)
Allogeneic stem cell transplant recipients
Solid organ transplant recipients
CMV pneumonia
Severe viral community-acquired pneumonia in immunocompetent adults
Proven CMV pneumonia requires clinical symptoms &/or signs of pneumonia
e.g., new airspace disease on imaging, hypoxia, tachypnea, &/or dyspnea
CMV documented in lung tissue
Virus isolation
Rapid culture
Histopathology
Immunohistochemistry
DNA hybridization techniques
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Kose A et al: Cytomegalovirus associated severe pneumonia in three liver transplant recipients. J Infect Dev Ctries. 14(11):1338-43, 2020
Kunihiro Y et al: Differential diagnosis of pulmonary infections in immunocompromised patients using high-resolution computed tomography. Eur Radiol. 29(11):6089-99, 2019
Restrepo-Gualteros SM et al: Challenges and clinical implications of the diagnosis of cytomegalovirus lung infection in children. Curr Infect Dis Rep. 21(7):24, 2019
Koo HJ et al: Radiographic and CT Features of viral pneumonia. Radiographics. 38(3):719-39, 2018
Shionoya Y et al: Cytomegalovirus pneumonia with progressive lung volume loss. Am J Case Rep. 19:1393-7, 2018
Almaghrabi RS et al: Cytomegalovirus infection in lung transplant recipients. Expert Rev Respir Med. 11(5):377-83, 2017
Ljungman P et al: Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials. Clin Infect Dis. 64(1):87-91, 2017
Kunihiro Y et al: The usefulness of a diagnostic method combining high-resolution CT findings and serum markers for cytomegalovirus pneumonia and pneumocystis pneumonia in non-AIDS patients. Acta Radiol. 56(7):806-13, 2015
Omeri AK et al: Comparison of high-resolution computed tomography findings between pseudomonas aeruginosa pneumonia and cytomegalovirus pneumonia. Eur Radiol. 24(12):3251-9, 2014
Cunha BA: Cytomegalovirus pneumonia: community-acquired pneumonia in immunocompetent hosts. Infect Dis Clin North Am. 24(1):147-58, 2010
Ison MG et al: Cytomegalovirus pneumonia in transplant recipients. Clin Chest Med. 26(4):691-705, viii, 2005
Chan KM et al: Infectious pulmonary complications in lung transplant recipients. Semin Respir Infect. 17(4):291-302, 2002
Kang EY et al: Cytomegalovirus pneumonia in transplant patients: CT findings. J Comput Assist Tomogr. 20(2):295-9, 1996
McGuinness G et al: Cytomegalovirus pneumonitis: spectrum of parenchymal CT findings with pathologic correlation in 21 AIDS patients. Radiology. 192(2):451-9, 1994
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