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Obstetrics
Diagnosis
Infection
Cytomegalovirus
Cytomegalovirus
Anne Kennedy, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Cytomegalovirus (CMV)

          IMAGING

          • General Features

            • Ultrasonographic Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Reporting Tips

                                Selected References

                                1. Diogo MC et al: The MRI spectrum of congenital cytomegalovirus infection. Prenat Diagn. 40(1):110-24, 2020
                                2. Kyriakopoulou A et al: Antenatal imaging and clinical outcome in congenital CMV infection: a field-wide systematic review and meta-analysis. J Infect. 80(4):407-18, 2020
                                3. Leruez-Ville M et al: Cytomegalovirus infection during pregnancy: state of the science. Am J Obstet Gynecol. 223(3):330-49, 2020
                                4. Leruez-Ville M et al: Quantifying the burden of congenital CMV infection (cCMV) with long-term sequelae in subsequent pregnancies of women seronegative at their first pregnancy. Clin Infect Dis. 71(7):1598-1603, 2020
                                5. Lin C et al: Diagnosis and medical care for congenital cytomegalovirus infection: an observational study using claims data in Japan, 2010 to 2017. Medicine (Baltimore). 99(10):e19419, 2020
                                6. Mussi-Pinhata MM et al: Natural history of congenital cytomegalovirus infection in highly seropositive populations. J Infect Dis. 221(Supplement_1):S15-22, 2020
                                7. Nicloux M et al: Outcome and management of newborns with congenital cytomegalovirus infection. Arch Pediatr. 27(3):160-5, 2020
                                8. Pellegrinelli L et al: Diagnosing congenital Cytomegalovirus infection: don't get rid of dried blood spots. BMC Infect Dis. 20(1):217, 2020
                                9. Giannattasio A et al: Neuroimaging profiles and neurodevelopmental outcome in infants with congenital Cytomegalovirus infection. Pediatr Infect Dis J. 37(10):1028-33, 2018
                                10. Kwak M et al: Brain magnetic resonance imaging findings of congenital cytomegalovirus infection as a prognostic factor for neurological outcome. Pediatr Neurol. 83:14-8, 2018
                                11. Egaña-Ugrinovic G et al: Congenital cytomegalovirus infection among twin pairs. J Matern Fetal Neonatal Med. 29(21):3439-44, 2016
                                12. Hadar E et al: Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection. J Perinat Med. 44(3):339-44, 2016
                                13. Society for Maternal-Fetal Medicine (SMFM). et al: Diagnosis and antenatal management of congenital Cytomegalovirus infection. Am J Obstet Gynecol. 214(6):B5-11, 2016
                                14. Hui L et al: Perinatal outcome after maternal primary cytomegalovirus infection in the first trimester: a practical update and counseling aid. Prenat Diagn. 35(1):1-7, 2015
                                15. McCormick AL et al: The immunological underpinnings of vaccinations to prevent cytomegalovirus disease. Cell Mol Immunol. 12(2):170-9, 2015
                                16. Naing ZW et al: Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. Aust N Z J Obstet Gynaecol. 56(1):9-18, 2015
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Clinical Issues

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Abbreviations

                                          • Cytomegalovirus (CMV)

                                        IMAGING

                                        • General Features

                                          • Ultrasonographic Findings

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Microscopic Features

                                                      CLINICAL ISSUES

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Reporting Tips

                                                              Selected References

                                                              1. Diogo MC et al: The MRI spectrum of congenital cytomegalovirus infection. Prenat Diagn. 40(1):110-24, 2020
                                                              2. Kyriakopoulou A et al: Antenatal imaging and clinical outcome in congenital CMV infection: a field-wide systematic review and meta-analysis. J Infect. 80(4):407-18, 2020
                                                              3. Leruez-Ville M et al: Cytomegalovirus infection during pregnancy: state of the science. Am J Obstet Gynecol. 223(3):330-49, 2020
                                                              4. Leruez-Ville M et al: Quantifying the burden of congenital CMV infection (cCMV) with long-term sequelae in subsequent pregnancies of women seronegative at their first pregnancy. Clin Infect Dis. 71(7):1598-1603, 2020
                                                              5. Lin C et al: Diagnosis and medical care for congenital cytomegalovirus infection: an observational study using claims data in Japan, 2010 to 2017. Medicine (Baltimore). 99(10):e19419, 2020
                                                              6. Mussi-Pinhata MM et al: Natural history of congenital cytomegalovirus infection in highly seropositive populations. J Infect Dis. 221(Supplement_1):S15-22, 2020
                                                              7. Nicloux M et al: Outcome and management of newborns with congenital cytomegalovirus infection. Arch Pediatr. 27(3):160-5, 2020
                                                              8. Pellegrinelli L et al: Diagnosing congenital Cytomegalovirus infection: don't get rid of dried blood spots. BMC Infect Dis. 20(1):217, 2020
                                                              9. Giannattasio A et al: Neuroimaging profiles and neurodevelopmental outcome in infants with congenital Cytomegalovirus infection. Pediatr Infect Dis J. 37(10):1028-33, 2018
                                                              10. Kwak M et al: Brain magnetic resonance imaging findings of congenital cytomegalovirus infection as a prognostic factor for neurological outcome. Pediatr Neurol. 83:14-8, 2018
                                                              11. Egaña-Ugrinovic G et al: Congenital cytomegalovirus infection among twin pairs. J Matern Fetal Neonatal Med. 29(21):3439-44, 2016
                                                              12. Hadar E et al: Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection. J Perinat Med. 44(3):339-44, 2016
                                                              13. Society for Maternal-Fetal Medicine (SMFM). et al: Diagnosis and antenatal management of congenital Cytomegalovirus infection. Am J Obstet Gynecol. 214(6):B5-11, 2016
                                                              14. Hui L et al: Perinatal outcome after maternal primary cytomegalovirus infection in the first trimester: a practical update and counseling aid. Prenat Diagn. 35(1):1-7, 2015
                                                              15. McCormick AL et al: The immunological underpinnings of vaccinations to prevent cytomegalovirus disease. Cell Mol Immunol. 12(2):170-9, 2015
                                                              16. Naing ZW et al: Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. Aust N Z J Obstet Gynaecol. 56(1):9-18, 2015