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Cytomegalovirus
Janice L. B. Byrne, MD; Anne M. Kennedy, MD
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KEY FACTS

  • Imaging

    • Clinical Issues

      • Diagnostic Checklist

        TERMINOLOGY

        • Abbreviations

          • Cytomegalovirus (CMV)

        IMAGING

        • General Features

          • Ultrasonographic Findings

            • MR Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Image Interpretation Pearls

                                • Reporting Tips

                                  Selected References

                                  1. Hadar E et al: Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection. J Perinat Med. ePub, 2015
                                  2. Hui L et al: Perinatal outcome after maternal primary cytomegalovirus infection in the first trimester: a practical update and counseling aid. Prenat Diagn. 35(1):1-7, 2015
                                  3. McCormick AL et al: The immunological underpinnings of vaccinations to prevent cytomegalovirus disease. Cell Mol Immunol. 12(2):170-9, 2015
                                  4. Naing ZW et al: Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. Aust N Z J Obstet Gynaecol. 56(1):9-18, 2015
                                  5. Lazzarotto T et al: Diagnosis and prognosis of congenital CMV infection: a case report and review of the literature. Scand J Clin Lab Invest Suppl. 244:34-40; discussion 39, 2014
                                  6. Nigro G: Hyperimmune globulin to prevent congenital CMV infection. N Engl J Med. 370(26):2544, 2014
                                  7. Prince HE et al: Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clin Vaccine Immunol. 21(10):1377-84, 2014
                                  8. Sherkat R et al: Seropositivity of cytomegalovirus in patients with recurrent pregnancy loss. J Res Med Sci. 19(Suppl 1):S22-5, 2014
                                  9. Doneda C et al: Early cerebral lesions in cytomegalovirus infection: prenatal MR imaging. Radiology. 255(2):613-21, 2010
                                  10. Fink KR et al: Neuroimaging of pediatric central nervous system cytomegalovirus infection. Radiographics. 30(7):1779-96, 2010
                                  11. Yinon Y et al: Cytomegalovirus infection in pregnancy. J Obstet Gynaecol Can. 32(4):348-54, 2010
                                  12. Cheeran MC et al: Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev. 22(1):99-126, Table of Contents, 2009
                                  13. Coll O et al: Guidelines on CMV congenital infection. J Perinat Med. 37(5):433-45, 2009
                                  14. Gabrielli L et al: Histological findings in foetuses congenitally infected by cytomegalovirus. J Clin Virol. 46 Suppl 4:S16-21, 2009
                                  15. Goegebuer T et al: Clinical predictive value of real-time PCR quantification of human cytomegalovirus DNA in amniotic fluid samples. J Clin Microbiol. 47(3):660-5, 2009
                                  16. Benoist G et al: Cytomegalovirus-related fetal brain lesions: comparison between targeted ultrasound examination and magnetic resonance imaging. Ultrasound Obstet Gynecol. 32(7):900-5, 2008
                                  17. Picone O et al: Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection. Prenat Diagn. 28(8):753-8, 2008
                                  18. Zalel Y et al: Secondary cytomegalovirus infection can cause severe fetal sequelae despite maternal preconceptional immunity. Ultrasound Obstet Gynecol. 31(4):417-20, 2008
                                  19. Salmaso R et al: Early detection by magnetic resonance imaging of fetal cerebral damage in a fetus with hydrops and cytomegalovirus infection. J Matern Fetal Neonatal Med. 20(7):559-61, 2007
                                  20. Malinger G et al: Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings. AJNR Am J Neuroradiol. 24(1):28-32, 2003
                                  21. Enders G et al: Prenatal diagnosis of congenital cytomegalovirus infection in 189 pregnancies with known outcome. Prenat Diagn. 21(5):362-77, 2001
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Imaging

                                    • Clinical Issues

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Abbreviations

                                          • Cytomegalovirus (CMV)

                                        IMAGING

                                        • General Features

                                          • Ultrasonographic Findings

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Microscopic Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Image Interpretation Pearls

                                                                • Reporting Tips

                                                                  Selected References

                                                                  1. Hadar E et al: Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection. J Perinat Med. ePub, 2015
                                                                  2. Hui L et al: Perinatal outcome after maternal primary cytomegalovirus infection in the first trimester: a practical update and counseling aid. Prenat Diagn. 35(1):1-7, 2015
                                                                  3. McCormick AL et al: The immunological underpinnings of vaccinations to prevent cytomegalovirus disease. Cell Mol Immunol. 12(2):170-9, 2015
                                                                  4. Naing ZW et al: Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. Aust N Z J Obstet Gynaecol. 56(1):9-18, 2015
                                                                  5. Lazzarotto T et al: Diagnosis and prognosis of congenital CMV infection: a case report and review of the literature. Scand J Clin Lab Invest Suppl. 244:34-40; discussion 39, 2014
                                                                  6. Nigro G: Hyperimmune globulin to prevent congenital CMV infection. N Engl J Med. 370(26):2544, 2014
                                                                  7. Prince HE et al: Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clin Vaccine Immunol. 21(10):1377-84, 2014
                                                                  8. Sherkat R et al: Seropositivity of cytomegalovirus in patients with recurrent pregnancy loss. J Res Med Sci. 19(Suppl 1):S22-5, 2014
                                                                  9. Doneda C et al: Early cerebral lesions in cytomegalovirus infection: prenatal MR imaging. Radiology. 255(2):613-21, 2010
                                                                  10. Fink KR et al: Neuroimaging of pediatric central nervous system cytomegalovirus infection. Radiographics. 30(7):1779-96, 2010
                                                                  11. Yinon Y et al: Cytomegalovirus infection in pregnancy. J Obstet Gynaecol Can. 32(4):348-54, 2010
                                                                  12. Cheeran MC et al: Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev. 22(1):99-126, Table of Contents, 2009
                                                                  13. Coll O et al: Guidelines on CMV congenital infection. J Perinat Med. 37(5):433-45, 2009
                                                                  14. Gabrielli L et al: Histological findings in foetuses congenitally infected by cytomegalovirus. J Clin Virol. 46 Suppl 4:S16-21, 2009
                                                                  15. Goegebuer T et al: Clinical predictive value of real-time PCR quantification of human cytomegalovirus DNA in amniotic fluid samples. J Clin Microbiol. 47(3):660-5, 2009
                                                                  16. Benoist G et al: Cytomegalovirus-related fetal brain lesions: comparison between targeted ultrasound examination and magnetic resonance imaging. Ultrasound Obstet Gynecol. 32(7):900-5, 2008
                                                                  17. Picone O et al: Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection. Prenat Diagn. 28(8):753-8, 2008
                                                                  18. Zalel Y et al: Secondary cytomegalovirus infection can cause severe fetal sequelae despite maternal preconceptional immunity. Ultrasound Obstet Gynecol. 31(4):417-20, 2008
                                                                  19. Salmaso R et al: Early detection by magnetic resonance imaging of fetal cerebral damage in a fetus with hydrops and cytomegalovirus infection. J Matern Fetal Neonatal Med. 20(7):559-61, 2007
                                                                  20. Malinger G et al: Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings. AJNR Am J Neuroradiol. 24(1):28-32, 2003
                                                                  21. Enders G et al: Prenatal diagnosis of congenital cytomegalovirus infection in 189 pregnancies with known outcome. Prenat Diagn. 21(5):362-77, 2001