link
Bookmarks
Dedifferentiated Chondrosarcoma
B.J. Manaster, MD, PhD, FACR
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
3
19
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        TERMINOLOGY

        • Synonyms

          • Chondrosarcoma with additional mesenchymal component
        • Definitions

          • Distinct variety of chondrosarcoma containing 2 distinct components
            • Well-differentiated cartilage tumor (usually low-grade chondrosarcoma, rarely enchondroma or osteochondroma)
            • High-grade noncartilaginous sarcoma (most commonly osteosarcoma or malignant fibrous histiocytoma)

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Staging, Grading, & Classification

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Bindiganavile S et al: Long-term outcome of chondrosarcoma: a single institutional experience. Cancer Res Treat. 47(4):897-903, 2015
                                    2. Kawaguchi S et al: Does ifosfamide therapy improve survival of patients with dedifferentiated chondrosarcoma? Clin Orthop Relat Res. 472(3):983-9, 2014
                                    3. Douis H et al: The imaging of cartilaginous bone tumours. II. Chondrosarcoma. Skeletal Radiol. 42(5):611-26, 2013
                                    4. Henderson ER et al: Dedifferentiated peripheral chondrosarcoma: a review of radiologic characteristics. Sarcoma. 2013:505321, 2013
                                    5. Mavrogenis AF et al: Dedifferentiated chondrosarcoma revisited. J Surg Orthop Adv. 20(2):106-11, 2011
                                    6. Akahane T et al: Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report. Arch Orthop Trauma Surg. 128(9):951-3, 2008
                                    7. Sopta J et al: Dedifferentiated chondrosarcoma: our clinico-pathological experience and dilemmas in 25 cases. J Cancer Res Clin Oncol. 134(2):147-52, 2008
                                    8. Grimer RJ et al: Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group. Eur J Cancer. 43(14):2060-5, 2007
                                    9. Staals EL et al: Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. J Bone Joint Surg Am. 89(5):987-93, 2007
                                    10. Staals EL et al: Dedifferentiated central chondrosarcoma. Cancer. 106(12):2682-91, 2006
                                    11. Bruns J et al: Dedifferentiated chondrosarcoma--a fatal disease. J Cancer Res Clin Oncol. 131(6):333-9, 2005
                                    12. Rinas AC et al: Potential sampling error in fine needle aspiration biopsy of dedifferentiated chondrosarcoma: a report of 4 cases. Acta Cytol. 49(5):554-9, 2005
                                    13. Dickey ID et al: Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. J Bone Joint Surg Am. 86-A(11):2412-8, 2004
                                    14. Littrell LA et al: Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases. Radiographics. 24(5):1397-409, 2004
                                    15. Milchgrub S et al: Dedifferentiated chondrosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002
                                    Related Anatomy
                                    Loading...
                                    Related Differential Diagnoses
                                    Loading...
                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          TERMINOLOGY

                                          • Synonyms

                                            • Chondrosarcoma with additional mesenchymal component
                                          • Definitions

                                            • Distinct variety of chondrosarcoma containing 2 distinct components
                                              • Well-differentiated cartilage tumor (usually low-grade chondrosarcoma, rarely enchondroma or osteochondroma)
                                              • High-grade noncartilaginous sarcoma (most commonly osteosarcoma or malignant fibrous histiocytoma)

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • MR Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Staging, Grading, & Classification

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Bindiganavile S et al: Long-term outcome of chondrosarcoma: a single institutional experience. Cancer Res Treat. 47(4):897-903, 2015
                                                                      2. Kawaguchi S et al: Does ifosfamide therapy improve survival of patients with dedifferentiated chondrosarcoma? Clin Orthop Relat Res. 472(3):983-9, 2014
                                                                      3. Douis H et al: The imaging of cartilaginous bone tumours. II. Chondrosarcoma. Skeletal Radiol. 42(5):611-26, 2013
                                                                      4. Henderson ER et al: Dedifferentiated peripheral chondrosarcoma: a review of radiologic characteristics. Sarcoma. 2013:505321, 2013
                                                                      5. Mavrogenis AF et al: Dedifferentiated chondrosarcoma revisited. J Surg Orthop Adv. 20(2):106-11, 2011
                                                                      6. Akahane T et al: Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report. Arch Orthop Trauma Surg. 128(9):951-3, 2008
                                                                      7. Sopta J et al: Dedifferentiated chondrosarcoma: our clinico-pathological experience and dilemmas in 25 cases. J Cancer Res Clin Oncol. 134(2):147-52, 2008
                                                                      8. Grimer RJ et al: Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group. Eur J Cancer. 43(14):2060-5, 2007
                                                                      9. Staals EL et al: Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. J Bone Joint Surg Am. 89(5):987-93, 2007
                                                                      10. Staals EL et al: Dedifferentiated central chondrosarcoma. Cancer. 106(12):2682-91, 2006
                                                                      11. Bruns J et al: Dedifferentiated chondrosarcoma--a fatal disease. J Cancer Res Clin Oncol. 131(6):333-9, 2005
                                                                      12. Rinas AC et al: Potential sampling error in fine needle aspiration biopsy of dedifferentiated chondrosarcoma: a report of 4 cases. Acta Cytol. 49(5):554-9, 2005
                                                                      13. Dickey ID et al: Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. J Bone Joint Surg Am. 86-A(11):2412-8, 2004
                                                                      14. Littrell LA et al: Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases. Radiographics. 24(5):1397-409, 2004
                                                                      15. Milchgrub S et al: Dedifferentiated chondrosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002