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Dedifferentiated Liposarcoma
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • Dedifferentiated liposarcoma (DDLS) is malignant fatty tumor showing progression from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) to nonlipogenic sarcoma of variable histologic grade
              • Bimorphic lesion with variable histologic grade of dedifferentiated portion

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Kilpatrick SE: Dedifferentiated liposarcoma: a comprehensive historical review with proposed evidence-based guidelines regarding a diagnosis in need of further clarification. Adv Anat Pathol. 28(6):426-38, 2021
                                      2. Yun JS et al: Dedifferentiated liposarcoma of the musculoskeletal system: expanded MR imaging spectrum from predominant fatty mass to non-fatty mass. Acta Radiol. 60(11):1474-81, 2019
                                      3. Shanbhogue AK et al: Uncommon primary pelvic retroperitoneal masses in adults: a pattern-based imaging approach. Radiographics. 32(3):795-817, 2012
                                      4. Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
                                      5. Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 493-8, 2008
                                      6. Dei Tos AP et al: Dedifferentiated liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 38-9, 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Definitions

                                                • Dedifferentiated liposarcoma (DDLS) is malignant fatty tumor showing progression from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) to nonlipogenic sarcoma of variable histologic grade
                                                  • Bimorphic lesion with variable histologic grade of dedifferentiated portion

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Kilpatrick SE: Dedifferentiated liposarcoma: a comprehensive historical review with proposed evidence-based guidelines regarding a diagnosis in need of further clarification. Adv Anat Pathol. 28(6):426-38, 2021
                                                                          2. Yun JS et al: Dedifferentiated liposarcoma of the musculoskeletal system: expanded MR imaging spectrum from predominant fatty mass to non-fatty mass. Acta Radiol. 60(11):1474-81, 2019
                                                                          3. Shanbhogue AK et al: Uncommon primary pelvic retroperitoneal masses in adults: a pattern-based imaging approach. Radiographics. 32(3):795-817, 2012
                                                                          4. Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
                                                                          5. Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 493-8, 2008
                                                                          6. Dei Tos AP et al: Dedifferentiated liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 38-9, 2002