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KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- Dedifferentiated liposarcoma (DDLS) is malignant fatty tumor showing progression from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) to nonlipogenic sarcoma of variable histologic grade
- Bimorphic lesion with variable histologic grade of dedifferentiated portion
- Dedifferentiated liposarcoma (DDLS) is malignant fatty tumor showing progression from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) to nonlipogenic sarcoma of variable histologic grade
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Kilpatrick SE: Dedifferentiated liposarcoma: a comprehensive historical review with proposed evidence-based guidelines regarding a diagnosis in need of further clarification. Adv Anat Pathol. 28(6):426-38, 2021
- Yun JS et al: Dedifferentiated liposarcoma of the musculoskeletal system: expanded MR imaging spectrum from predominant fatty mass to non-fatty mass. Acta Radiol. 60(11):1474-81, 2019
- Shanbhogue AK et al: Uncommon primary pelvic retroperitoneal masses in adults: a pattern-based imaging approach. Radiographics. 32(3):795-817, 2012
- Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
- Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 493-8, 2008
- Dei Tos AP et al: Dedifferentiated liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 38-9, 2002
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- Dedifferentiated liposarcoma (DDLS) is malignant fatty tumor showing progression from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) to nonlipogenic sarcoma of variable histologic grade
- Bimorphic lesion with variable histologic grade of dedifferentiated portion
- Dedifferentiated liposarcoma (DDLS) is malignant fatty tumor showing progression from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) to nonlipogenic sarcoma of variable histologic grade
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Kilpatrick SE: Dedifferentiated liposarcoma: a comprehensive historical review with proposed evidence-based guidelines regarding a diagnosis in need of further clarification. Adv Anat Pathol. 28(6):426-38, 2021
- Yun JS et al: Dedifferentiated liposarcoma of the musculoskeletal system: expanded MR imaging spectrum from predominant fatty mass to non-fatty mass. Acta Radiol. 60(11):1474-81, 2019
- Shanbhogue AK et al: Uncommon primary pelvic retroperitoneal masses in adults: a pattern-based imaging approach. Radiographics. 32(3):795-817, 2012
- Craig WD et al: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29(1):261-90, 2009
- Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 493-8, 2008
- Dei Tos AP et al: Dedifferentiated liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 38-9, 2002
