Morphologically benign fibrohistiocytic neoplasm that arises entirely within subcutaneous or deep soft tissue and may metastasize occasionally
Cutaneous/dermal form referred to as superficial benign fibrous histiocytoma, dermal histiocytoma, or dermatofibroma
WHO: Lesions currently referred to as deep benign fibrous histiocytoma in any location, including subcutaneous site
IMAGING
General Features
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
Genetics
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Leow MKS et al: Paraneoplastic secretion of multiple phosphatonins from a deep fibrous histiocytoma causing oncogenic osteomalacia. J Clin Endocrinol Metab. 106(5):e2299-308, 2021
Jo VY: Deep fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 137-8, 2020
Thomas KL et al: Test yourself: answer - deep benign fibrous histiocytoma. Skeletal Radiol. 44(8):1151-2, 1209-10, 2015
Yamasaki F et al: Benign fibrous histiocytoma arising at the temporal bone of an infant-case report and review of the literature. Childs Nerv Syst. 32(1):189-93, 2016
Varma P et al: Benign fibrous histiocytoma. Indian J Ophthalmol. 62(4):464-7, 2014
Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 289-92, 2014
Doyle LA et al: Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 37(4):484-95, 2013
Gleason BC et al: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 32(3):354-62, 2008
Weiss SW et al: Benign fibrohistiocytic tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 331-42, 2008
Coindre JM: Deep benign fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 114-5, 2002
Mentzel T et al: Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 23(5):419-26, 2001
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
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TERMINOLOGY
Definitions
Morphologically benign fibrohistiocytic neoplasm that arises entirely within subcutaneous or deep soft tissue and may metastasize occasionally
Cutaneous/dermal form referred to as superficial benign fibrous histiocytoma, dermal histiocytoma, or dermatofibroma
WHO: Lesions currently referred to as deep benign fibrous histiocytoma in any location, including subcutaneous site
IMAGING
General Features
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
Genetics
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Leow MKS et al: Paraneoplastic secretion of multiple phosphatonins from a deep fibrous histiocytoma causing oncogenic osteomalacia. J Clin Endocrinol Metab. 106(5):e2299-308, 2021
Jo VY: Deep fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 137-8, 2020
Thomas KL et al: Test yourself: answer - deep benign fibrous histiocytoma. Skeletal Radiol. 44(8):1151-2, 1209-10, 2015
Yamasaki F et al: Benign fibrous histiocytoma arising at the temporal bone of an infant-case report and review of the literature. Childs Nerv Syst. 32(1):189-93, 2016
Varma P et al: Benign fibrous histiocytoma. Indian J Ophthalmol. 62(4):464-7, 2014
Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 289-92, 2014
Doyle LA et al: Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 37(4):484-95, 2013
Gleason BC et al: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 32(3):354-62, 2008
Weiss SW et al: Benign fibrohistiocytic tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 331-42, 2008
Coindre JM: Deep benign fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 114-5, 2002
Mentzel T et al: Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 23(5):419-26, 2001
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