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Deep Benign Fibrous Histiocytoma
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Morphologically benign fibrohistiocytic neoplasm that arises entirely within subcutaneous or deep soft tissue and may metastasize occasionally
                • Cutaneous/dermal form referred to as superficial benign fibrous histiocytoma, dermal histiocytoma, or dermatofibroma
              • WHO: Lesions currently referred to as deep benign fibrous histiocytoma in any location, including subcutaneous site

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • Staging, Grading, & Classification

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          • Genetics

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Leow MKS et al: Paraneoplastic secretion of multiple phosphatonins from a deep fibrous histiocytoma causing oncogenic osteomalacia. J Clin Endocrinol Metab. 106(5):e2299-308, 2021
                                    2. Jo VY: Deep fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 137-8, 2020
                                    3. Thomas KL et al: Test yourself: answer - deep benign fibrous histiocytoma. Skeletal Radiol. 44(8):1151-2, 1209-10, 2015
                                    4. Yamasaki F et al: Benign fibrous histiocytoma arising at the temporal bone of an infant-case report and review of the literature. Childs Nerv Syst. 32(1):189-93, 2016
                                    5. Varma P et al: Benign fibrous histiocytoma. Indian J Ophthalmol. 62(4):464-7, 2014
                                    6. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 289-92, 2014
                                    7. Doyle LA et al: Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 37(4):484-95, 2013
                                    8. Gleason BC et al: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 32(3):354-62, 2008
                                    9. Weiss SW et al: Benign fibrohistiocytic tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 331-42, 2008
                                    10. Coindre JM: Deep benign fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 114-5, 2002
                                    11. Mentzel T et al: Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 23(5):419-26, 2001
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Definitions

                                                • Morphologically benign fibrohistiocytic neoplasm that arises entirely within subcutaneous or deep soft tissue and may metastasize occasionally
                                                  • Cutaneous/dermal form referred to as superficial benign fibrous histiocytoma, dermal histiocytoma, or dermatofibroma
                                                • WHO: Lesions currently referred to as deep benign fibrous histiocytoma in any location, including subcutaneous site

                                              IMAGING

                                              • General Features

                                                • CT Findings

                                                  • MR Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • Staging, Grading, & Classification

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            • Genetics

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Leow MKS et al: Paraneoplastic secretion of multiple phosphatonins from a deep fibrous histiocytoma causing oncogenic osteomalacia. J Clin Endocrinol Metab. 106(5):e2299-308, 2021
                                                                      2. Jo VY: Deep fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 137-8, 2020
                                                                      3. Thomas KL et al: Test yourself: answer - deep benign fibrous histiocytoma. Skeletal Radiol. 44(8):1151-2, 1209-10, 2015
                                                                      4. Yamasaki F et al: Benign fibrous histiocytoma arising at the temporal bone of an infant-case report and review of the literature. Childs Nerv Syst. 32(1):189-93, 2016
                                                                      5. Varma P et al: Benign fibrous histiocytoma. Indian J Ophthalmol. 62(4):464-7, 2014
                                                                      6. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 289-92, 2014
                                                                      7. Doyle LA et al: Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 37(4):484-95, 2013
                                                                      8. Gleason BC et al: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 32(3):354-62, 2008
                                                                      9. Weiss SW et al: Benign fibrohistiocytic tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 331-42, 2008
                                                                      10. Coindre JM: Deep benign fibrous histiocytoma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 114-5, 2002
                                                                      11. Mentzel T et al: Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 23(5):419-26, 2001