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Deep Benign Fibrous Histiocytoma
Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Fibroxanthoma, dermatofibroma, sclerosing hemangioma, dermal histiocytoma, histiocytoma cutis, and nodular subepidermal fibrosis
          • Definitions

            • Rare, benign fibrohistiocytic neoplasm located in subcutaneous tissue, deep soft tissue, or organs
              • Cutaneous form referred to as benign fibrous histiocytoma or dermatofibroma

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • Staging, Grading, & Classification

                    • Gross Pathologic & Surgical Features

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Thomas KL et al: Test yourself: answer - deep benign fibrous histiocytoma. Skeletal Radiol. 44(8):1151-2, 1209-10, 2015
                                2. Yamasaki F et al: Benign fibrous histiocytoma arising at the temporal bone of an infant-case report and review of the literature. Childs Nerv Syst. ePub, 2015
                                3. Varma P et al: Benign fibrous histiocytoma. Indian J Ophthalmol. 62(4):464-7, 2014
                                4. Doyle LA et al: Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 37(4):484-95, 2013
                                5. Gleason BC et al: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 32(3):354-62, 2008
                                6. Weiss SW et al: Benign fibrohistiocytic tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 331-42, 2008
                                7. Kransdorf MJ et al: Benign fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 195-6, 2006
                                8. Coindre JM: Deep benign fibrous histiocytoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 114-5, 2002
                                9. Mentzel T et al: Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 23(5):419-26, 2001
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Pathology

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Synonyms

                                          • Fibroxanthoma, dermatofibroma, sclerosing hemangioma, dermal histiocytoma, histiocytoma cutis, and nodular subepidermal fibrosis
                                        • Definitions

                                          • Rare, benign fibrohistiocytic neoplasm located in subcutaneous tissue, deep soft tissue, or organs
                                            • Cutaneous form referred to as benign fibrous histiocytoma or dermatofibroma

                                        IMAGING

                                        • General Features

                                          • CT Findings

                                            • MR Findings

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • Staging, Grading, & Classification

                                                  • Gross Pathologic & Surgical Features

                                                    • Microscopic Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Thomas KL et al: Test yourself: answer - deep benign fibrous histiocytoma. Skeletal Radiol. 44(8):1151-2, 1209-10, 2015
                                                              2. Yamasaki F et al: Benign fibrous histiocytoma arising at the temporal bone of an infant-case report and review of the literature. Childs Nerv Syst. ePub, 2015
                                                              3. Varma P et al: Benign fibrous histiocytoma. Indian J Ophthalmol. 62(4):464-7, 2014
                                                              4. Doyle LA et al: Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 37(4):484-95, 2013
                                                              5. Gleason BC et al: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 32(3):354-62, 2008
                                                              6. Weiss SW et al: Benign fibrohistiocytic tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 331-42, 2008
                                                              7. Kransdorf MJ et al: Benign fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 195-6, 2006
                                                              8. Coindre JM: Deep benign fibrous histiocytoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 114-5, 2002
                                                              9. Mentzel T et al: Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 23(5):419-26, 2001