link
Bookmarks
 (0)
Spine
Diagnosis
Degenerative Diseases and Arthritides
Degenerative Diseases
Degenerative Endplate Changes
Degenerative Endplate Changes
Jeffrey S. Ross, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Subscribe
0
0
4
0

KEY FACTS

  • Terminology

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Vertebral endplate change, Modic changes
            • Type I, II, III endplate change

          • Definitions

            • MR signal abnormalities involving vertebral body endplates related to degenerative disc disease
              • Type I: Hypointense on T1WI, hyperintense on T2WI
              • Type II: Hyperintense on T1WI, isointense on T2WI
              • Type III: Hypointense on T1WI and T2WI

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Chen Y et al: Distribution of Modic changes in patients with low back pain and its related factors. Eur J Med Res. 24(1):34, 2019
                                            2. Dudli S et al: Pathobiology of Modic changes. Eur Spine J. 25(11):3723-34, 2016
                                            3. Albert HB et al: Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. Eur Spine J. 22(4):697-707, 2013
                                            4. Luoma K et al: Relationship of Modic type 1 change with disc degeneration: a prospective MRI study. Skeletal Radiol. 38(3):237-44, 2009
                                            5. Thompson KJ et al: Modic changes on MR images as studied with provocative diskography: clinical relevance--a retrospective study of 2457 disks. Radiology. 250(3):849-55, 2009
                                            6. Jensen TS et al: Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J. 17(11):1407-22, 2008
                                            7. Rahme R et al: The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental instability of the lumbar spine. AJNR Am J Neuroradiol. 29(5):838-42, 2008
                                            8. Zhang YH et al: Modic changes: a systematic review of the literature. Eur Spine J. 17(10):1289-99, 2008
                                            9. Modic MT et al: Lumbar degenerative disk disease. Radiology. 245(1):43-61, 2007
                                            10. Senegas J: Mechanical supplementation by non-rigid fixation in degenerative intervertebral lumbar segments: the Wallis system. Eur Spine J. 11 Suppl 2: S164-9, 2002
                                            11. Stumpe KD et al: FDG positron emission tomography for differentiation of degenerative and infectious endplate abnormalities in the lumbar spine detected on MR imaging. AJR Am J Roentgenol. 179(5): 1151-7, 2002
                                            12. Weishaupt D et al: Painful lumbar disk derangement: relevance of endplate abnormalities at MR imaging. Radiology. 218(2):420-7, 2001
                                            13. Sandhu HS et al: Association between findings of provocative discography and vertebral endplate signal changes as seen on MRI. J Spinal Disord. 13(5): 438-43, 2000
                                            14. Van Goethem JW et al: The value of MRI in the diagnosis of postoperative spondylodiscitis. Neuroradiology. 42(8): 580-5, 2000
                                            15. Braithwaite I et al: Vertebral end-plate (Modic) changes on lumbar spine MRI: correlation with pain reproduction at lumbar discography. Eur Spine J. 7(5):363-8, 1998
                                            16. Ito M et al: Predictive signs of discogenic lumbar pain on magnetic resonance imaging with discography correlation. Spine. 23(11): 1252-8; discussion 1259-60, 1998
                                            17. Ross JS et al: The postoperative lumbar spine: enhanced MR evaluation of the intervertebral disk. AJNR Am J Neuroradiol. 17(2): 323-31, 1996
                                            18. Modic MT et al: Contrast-enhanced MR imaging in acute lumbar radiculopathy: a pilot study of the natural history. Radiology. 195(2): 429-35, 1995
                                            19. Ulmer JL et al: Lumbar spondylolysis: reactive marrow changes seen in adjacent pedicles on MR images. AJR Am J Roentgenol. 164(2): 429-33, 1995
                                            20. Ross JS et al: Current assessment of spinal degenerative disease with magnetic resonance imaging. Clin Orthop. (279): 68-81, 1992
                                            21. Ross JS et al: Assessment of extradural degenerative disease with Gd-DTPA-enhanced MR imaging: correlation with surgical and pathologic findings. AJNR Am J Neuroradiol. 10(6):1243-9, 1989
                                            22. Hueftle MG et al: Lumbar spine: postoperative MR imaging with Gd-DTPA. Radiology. 167(3):817-24, 1988
                                            23. Masaryk TJ et al: High-resolution MR imaging of sequestered lumbar intervertebral disks. AJR Am J Roentgenol. 150(5):1155-62, 1988
                                            24. Modic MT et al: Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 166(1 Pt 1):193-9, 1988
                                            Related Anatomy
                                            Loading...
                                            Related Differential Diagnoses
                                            Loading...
                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Vertebral endplate change, Modic changes
                                                      • Type I, II, III endplate change

                                                    • Definitions

                                                      • MR signal abnormalities involving vertebral body endplates related to degenerative disc disease
                                                        • Type I: Hypointense on T1WI, hyperintense on T2WI
                                                        • Type II: Hyperintense on T1WI, isointense on T2WI
                                                        • Type III: Hypointense on T1WI and T2WI

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Chen Y et al: Distribution of Modic changes in patients with low back pain and its related factors. Eur J Med Res. 24(1):34, 2019
                                                                                      2. Dudli S et al: Pathobiology of Modic changes. Eur Spine J. 25(11):3723-34, 2016
                                                                                      3. Albert HB et al: Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. Eur Spine J. 22(4):697-707, 2013
                                                                                      4. Luoma K et al: Relationship of Modic type 1 change with disc degeneration: a prospective MRI study. Skeletal Radiol. 38(3):237-44, 2009
                                                                                      5. Thompson KJ et al: Modic changes on MR images as studied with provocative diskography: clinical relevance--a retrospective study of 2457 disks. Radiology. 250(3):849-55, 2009
                                                                                      6. Jensen TS et al: Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J. 17(11):1407-22, 2008
                                                                                      7. Rahme R et al: The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental instability of the lumbar spine. AJNR Am J Neuroradiol. 29(5):838-42, 2008
                                                                                      8. Zhang YH et al: Modic changes: a systematic review of the literature. Eur Spine J. 17(10):1289-99, 2008
                                                                                      9. Modic MT et al: Lumbar degenerative disk disease. Radiology. 245(1):43-61, 2007
                                                                                      10. Senegas J: Mechanical supplementation by non-rigid fixation in degenerative intervertebral lumbar segments: the Wallis system. Eur Spine J. 11 Suppl 2: S164-9, 2002
                                                                                      11. Stumpe KD et al: FDG positron emission tomography for differentiation of degenerative and infectious endplate abnormalities in the lumbar spine detected on MR imaging. AJR Am J Roentgenol. 179(5): 1151-7, 2002
                                                                                      12. Weishaupt D et al: Painful lumbar disk derangement: relevance of endplate abnormalities at MR imaging. Radiology. 218(2):420-7, 2001
                                                                                      13. Sandhu HS et al: Association between findings of provocative discography and vertebral endplate signal changes as seen on MRI. J Spinal Disord. 13(5): 438-43, 2000
                                                                                      14. Van Goethem JW et al: The value of MRI in the diagnosis of postoperative spondylodiscitis. Neuroradiology. 42(8): 580-5, 2000
                                                                                      15. Braithwaite I et al: Vertebral end-plate (Modic) changes on lumbar spine MRI: correlation with pain reproduction at lumbar discography. Eur Spine J. 7(5):363-8, 1998
                                                                                      16. Ito M et al: Predictive signs of discogenic lumbar pain on magnetic resonance imaging with discography correlation. Spine. 23(11): 1252-8; discussion 1259-60, 1998
                                                                                      17. Ross JS et al: The postoperative lumbar spine: enhanced MR evaluation of the intervertebral disk. AJNR Am J Neuroradiol. 17(2): 323-31, 1996
                                                                                      18. Modic MT et al: Contrast-enhanced MR imaging in acute lumbar radiculopathy: a pilot study of the natural history. Radiology. 195(2): 429-35, 1995
                                                                                      19. Ulmer JL et al: Lumbar spondylolysis: reactive marrow changes seen in adjacent pedicles on MR images. AJR Am J Roentgenol. 164(2): 429-33, 1995
                                                                                      20. Ross JS et al: Current assessment of spinal degenerative disease with magnetic resonance imaging. Clin Orthop. (279): 68-81, 1992
                                                                                      21. Ross JS et al: Assessment of extradural degenerative disease with Gd-DTPA-enhanced MR imaging: correlation with surgical and pathologic findings. AJNR Am J Neuroradiol. 10(6):1243-9, 1989
                                                                                      22. Hueftle MG et al: Lumbar spine: postoperative MR imaging with Gd-DTPA. Radiology. 167(3):817-24, 1988
                                                                                      23. Masaryk TJ et al: High-resolution MR imaging of sequestered lumbar intervertebral disks. AJR Am J Roentgenol. 150(5):1155-62, 1988
                                                                                      24. Modic MT et al: Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 166(1 Pt 1):193-9, 1988