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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Dementia with Lewy bodies (DLB)
Definitions
- Neurodegenerative dementia characterized by cognitive fluctuations, visual hallucinations, & motor parkinsonism
- Caused by pathologic aggregation of α-synuclein protein in neurites (LB)
- Neurodegenerative dementia characterized by cognitive fluctuations, visual hallucinations, & motor parkinsonism
IMAGING
General Features
Imaging Recommendations
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Colloby SJ et al: Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia. Aust N Z J Psychiatry. 4867419885165, 2019
- Gupta V et al: Metabolic imaging patterns in posterior cortical atrophy and Lewy body dementia. Nucl Med Commun. 40(12):1275-82, 2019
- Yamada M et al: Diagnostic criteria for dementia with lewy bodies: updates and future directions. J Mov Disord. ePub, 2019
- Orimo S: [Differential diagnosis of dementia with lewy bodies.] Brain Nerve. 67(4):413-25, 2015
- Bertelson JA et al: Neuroimaging of dementia. Neurol Clin. 32(1):59-93, 2014
- Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
- Mak E et al: Neuroimaging characteristics of dementia with Lewy bodies. Alzheimers Res Ther. 6(2):18, 2014
- Peraza LR et al: fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies. Neuroimage Clin. 4:558-65, 2014
- Bhogal P et al: The common dementias: a pictorial review. Eur Radiol. 23(12):3405-17, 2013
- Mortimer AM et al: Neuroimaging in dementia: a practical guide. Pract Neurol. 13(2):92-103, 2013
- Burton EJ et al: Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis. Brain. 132(Pt 1):195-203, 2009
- Ota M et al: Degeneration of dementia with Lewy bodies measured by diffusion tensor imaging. NMR Biomed. 22(3):280-4, 2009
- Watson R et al: Magnetic resonance imaging in lewy body dementias. Dement Geriatr Cogn Disord. 28(6):493-506, 2009
- Edison P et al: Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry. 79(12):1331-8, 2008
- Perneczky R et al: Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations. Dement Geriatr Cogn Disord. 25(6):531-8, 2008
- Schmidt SL et al: Value of combining activated brain FDG-PET and cardiac MIBG for the differential diagnosis of dementia: differentiation of dementia with Lewy bodies and Alzheimer disease when the diagnoses based on clinical and neuroimaging criteria are difficult. Clin Nucl Med. 33(6):398-401, 2008
- McKeith I et al: Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 6(4):305-13, 2007
- Seppi K et al: Dementia with Lewy bodies and Parkinson disease with dementia: can MRI make the difference? Neurology. 69(8):717-8, 2007
- Whitwell JL et al: Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain. 130(Pt 3):708-19, 2007
- Burton EJ et al: Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging. Am J Geriatr Psychiatry. 14(10):842-9, 2006
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Dementia with Lewy bodies (DLB)
Definitions
- Neurodegenerative dementia characterized by cognitive fluctuations, visual hallucinations, & motor parkinsonism
- Caused by pathologic aggregation of α-synuclein protein in neurites (LB)
- Neurodegenerative dementia characterized by cognitive fluctuations, visual hallucinations, & motor parkinsonism
IMAGING
General Features
Imaging Recommendations
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Colloby SJ et al: Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia. Aust N Z J Psychiatry. 4867419885165, 2019
- Gupta V et al: Metabolic imaging patterns in posterior cortical atrophy and Lewy body dementia. Nucl Med Commun. 40(12):1275-82, 2019
- Yamada M et al: Diagnostic criteria for dementia with lewy bodies: updates and future directions. J Mov Disord. ePub, 2019
- Orimo S: [Differential diagnosis of dementia with lewy bodies.] Brain Nerve. 67(4):413-25, 2015
- Bertelson JA et al: Neuroimaging of dementia. Neurol Clin. 32(1):59-93, 2014
- Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
- Mak E et al: Neuroimaging characteristics of dementia with Lewy bodies. Alzheimers Res Ther. 6(2):18, 2014
- Peraza LR et al: fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies. Neuroimage Clin. 4:558-65, 2014
- Bhogal P et al: The common dementias: a pictorial review. Eur Radiol. 23(12):3405-17, 2013
- Mortimer AM et al: Neuroimaging in dementia: a practical guide. Pract Neurol. 13(2):92-103, 2013
- Burton EJ et al: Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis. Brain. 132(Pt 1):195-203, 2009
- Ota M et al: Degeneration of dementia with Lewy bodies measured by diffusion tensor imaging. NMR Biomed. 22(3):280-4, 2009
- Watson R et al: Magnetic resonance imaging in lewy body dementias. Dement Geriatr Cogn Disord. 28(6):493-506, 2009
- Edison P et al: Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry. 79(12):1331-8, 2008
- Perneczky R et al: Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations. Dement Geriatr Cogn Disord. 25(6):531-8, 2008
- Schmidt SL et al: Value of combining activated brain FDG-PET and cardiac MIBG for the differential diagnosis of dementia: differentiation of dementia with Lewy bodies and Alzheimer disease when the diagnoses based on clinical and neuroimaging criteria are difficult. Clin Nucl Med. 33(6):398-401, 2008
- McKeith I et al: Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 6(4):305-13, 2007
- Seppi K et al: Dementia with Lewy bodies and Parkinson disease with dementia: can MRI make the difference? Neurology. 69(8):717-8, 2007
- Whitwell JL et al: Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain. 130(Pt 3):708-19, 2007
- Burton EJ et al: Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging. Am J Geriatr Psychiatry. 14(10):842-9, 2006
