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Denervation Hypertrophy
Cheryl A. Petersilge, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Neurogenic muscular hypertrophy
            • Definitions

              • Pseudohypertrophy: Generalized enlargement of muscle with increase in intramuscular fat
              • True hypertrophy: Generalized enlargement of muscle due to increase in muscle tissue

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Natural History & Prognosis

                              • Treatment

                                DIAGNOSTIC CHECKLIST

                                • Reporting Tips

                                  Selected References

                                  1. Evertsson K et al: p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscle. J Mol Signal. 9(1):2, 2014
                                  2. Hemmi S et al: Unilateral calf hypertrophy and focal myositis induced by S1 radiculopathy: dramatic response to steroid treatment. BMJ Case Rep. 2013, 2013
                                  3. Petersilge CA et al: Denervation hypertrophy of muscle: MR features. J Comput Assist Tomogr. 19(4):596-600, 1995
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Synonyms

                                              • Neurogenic muscular hypertrophy
                                            • Definitions

                                              • Pseudohypertrophy: Generalized enlargement of muscle with increase in intramuscular fat
                                              • True hypertrophy: Generalized enlargement of muscle due to increase in muscle tissue

                                            IMAGING

                                            • General Features

                                              • Imaging Recommendations

                                                • CT Findings

                                                  • MR Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Natural History & Prognosis

                                                              • Treatment

                                                                DIAGNOSTIC CHECKLIST

                                                                • Reporting Tips

                                                                  Selected References

                                                                  1. Evertsson K et al: p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscle. J Mol Signal. 9(1):2, 2014
                                                                  2. Hemmi S et al: Unilateral calf hypertrophy and focal myositis induced by S1 radiculopathy: dramatic response to steroid treatment. BMJ Case Rep. 2013, 2013
                                                                  3. Petersilge CA et al: Denervation hypertrophy of muscle: MR features. J Comput Assist Tomogr. 19(4):596-600, 1995