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Desmoplastic Fibroma
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Desmoid tumor of bone, intraosseous counterpart of soft tissue fibromatosis
        • Definitions

          • Rare benign bone tumor consisting of spindle cells with minimal cellular atypia

        IMAGING

        • General Features

          • Imaging Recommendations

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Okubo T et al: Desmoplastic fibroma of the rib with cystic change: a case report and literature review. Skeletal Radiol. 43(5):703-8, 2014
                                    2. Yin H et al: Desmoplastic fibroma of the spine: a series of 12 cases and outcomes. Spine J. 14(8):1622-8, 2014
                                    3. Wadhwa V et al: Incidental lesion in the femoral metaphysis. Desmoplastic fibroma of the bone. Skeletal Radiol. 42(12):1739-40, 1775-6, 2013
                                    4. Apaydin M et al: Desmoplastic fibroma in humerus. J Med Imaging Radiat Oncol. 52(5):489-90, 2008
                                    5. Rastogi S et al: Desmoplastic fibroma: a report of three cases at unusual locations. Joint Bone Spine. 75(2):222-5, 2008
                                    6. Callahan KS et al: Desmoplastic fibroma of bone with extensive cartilaginous metaplasia. Ann Diagn Pathol. 10(6):343-6, 2006
                                    7. Frick MA et al: Imaging findings in desmoplastic fibroma of bone: distinctive T2 characteristics. AJR Am J Roentgenol. 184(6):1762-7, 2005
                                    8. Hauben EI et al: Desmoplastic fibroma of bone: an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin. Hum Pathol. 36(9):1025-30, 2005
                                    9. Bahk WJ et al: Desmoid tumor of bone with enchondromatous nodules, mistaken for chondrosarcoma. Skeletal Radiol. 32(4):223-6, 2003
                                    10. Takazawa K et al: Osteosarcoma arising from desmoplastic fibroma treated 16 years earlier: a case report. J Orthop Sci. 8(6):864-8, 2003
                                    11. Fornasier V et al: In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of soft tissue and bone. Lyon: IARC Press. 2002
                                    12. Crim JR et al: Desmoplastic fibroma of bone: radiographic analysis. Radiology. 172(3):827-32, 1989
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Synonyms

                                            • Desmoid tumor of bone, intraosseous counterpart of soft tissue fibromatosis
                                          • Definitions

                                            • Rare benign bone tumor consisting of spindle cells with minimal cellular atypia

                                          IMAGING

                                          • General Features

                                            • Imaging Recommendations

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Okubo T et al: Desmoplastic fibroma of the rib with cystic change: a case report and literature review. Skeletal Radiol. 43(5):703-8, 2014
                                                                      2. Yin H et al: Desmoplastic fibroma of the spine: a series of 12 cases and outcomes. Spine J. 14(8):1622-8, 2014
                                                                      3. Wadhwa V et al: Incidental lesion in the femoral metaphysis. Desmoplastic fibroma of the bone. Skeletal Radiol. 42(12):1739-40, 1775-6, 2013
                                                                      4. Apaydin M et al: Desmoplastic fibroma in humerus. J Med Imaging Radiat Oncol. 52(5):489-90, 2008
                                                                      5. Rastogi S et al: Desmoplastic fibroma: a report of three cases at unusual locations. Joint Bone Spine. 75(2):222-5, 2008
                                                                      6. Callahan KS et al: Desmoplastic fibroma of bone with extensive cartilaginous metaplasia. Ann Diagn Pathol. 10(6):343-6, 2006
                                                                      7. Frick MA et al: Imaging findings in desmoplastic fibroma of bone: distinctive T2 characteristics. AJR Am J Roentgenol. 184(6):1762-7, 2005
                                                                      8. Hauben EI et al: Desmoplastic fibroma of bone: an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin. Hum Pathol. 36(9):1025-30, 2005
                                                                      9. Bahk WJ et al: Desmoid tumor of bone with enchondromatous nodules, mistaken for chondrosarcoma. Skeletal Radiol. 32(4):223-6, 2003
                                                                      10. Takazawa K et al: Osteosarcoma arising from desmoplastic fibroma treated 16 years earlier: a case report. J Orthop Sci. 8(6):864-8, 2003
                                                                      11. Fornasier V et al: In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of soft tissue and bone. Lyon: IARC Press. 2002
                                                                      12. Crim JR et al: Desmoplastic fibroma of bone: radiographic analysis. Radiology. 172(3):827-32, 1989