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Developing Asymmetry
Nicole S. Winkler, MD; Wendie A. Berg, MD, PhD, FACR, FSBI
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Developing density, neodensity
              • Definitions

                • Developing asymmetry: Mammographic focal asymmetry (< 1 quadrant), which is new, larger, or more conspicuous than on prior examination(s)
                • Focal asymmetry: Compared to contralateral breast, greater amount of fibroglandular tissue over confined portion of breast (< 1 quadrant)
                  • Visible in 2 or more projections
                  • Concave margins; usually contains interspersed fat

              IMAGING

              • General Features

                • Mammographic Findings

                  • Ultrasonographic Findings

                    • MR Findings

                      • Imaging Recommendations

                        • Image-Guided Biopsy

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Giess CS et al: Ultrasound features of mammographic developing asymmetries and correlation with histopathologic findings. AJR Am J Roentgenol. 210(1):W29-W38, 2018
                                      2. Giess CS et al: Clinical Utility of Breast MRI in the Diagnosis of Malignancy After Inconclusive or Equivocal Mammographic Diagnostic Evaluation. AJR Am J Roentgenol. 208(6):1378-1385, 2017
                                      3. Chesebro AL et al: Developing Asymmetry at Mammography: Correlation with US and MR Imaging and Histopathologic Findings. Radiology. 279(2):385-94, 2016
                                      4. Chesebro AL et al: Developing Asymmetries at Mammography: A Multimodality Approach to Assessment and Management. Radiographics. 36(2):322-34, 2016
                                      5. Venkatesan A et al: Positive predictive value of specific mammographic findings according to reader and patient variables. Radiology. 250(3):648-57, 2009
                                      6. Youk JH et al: Asymmetric mammographic findings based on the fourth edition of BI-RADS: types, evaluation, and management. Radiographics. 29(1):e33, 2009
                                      7. Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
                                      8. Sickles EA: The spectrum of breast asymmetries: imaging features, work-up, management. Radiol Clin North Am. 45(5):765-71, v, 2007
                                      9. Samardar P et al: Focal asymmetric densities seen at mammography: US and pathologic correlation. Radiographics. 22(1):19-33, 2002
                                      10. VizcaĆ­no I et al: Short-term follow-up results in 795 nonpalpable probably benign lesions detected at screening mammography. Radiology. 219(2):475-83, 2001
                                      11. Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Developing density, neodensity
                                                  • Definitions

                                                    • Developing asymmetry: Mammographic focal asymmetry (< 1 quadrant), which is new, larger, or more conspicuous than on prior examination(s)
                                                    • Focal asymmetry: Compared to contralateral breast, greater amount of fibroglandular tissue over confined portion of breast (< 1 quadrant)
                                                      • Visible in 2 or more projections
                                                      • Concave margins; usually contains interspersed fat

                                                  IMAGING

                                                  • General Features

                                                    • Mammographic Findings

                                                      • Ultrasonographic Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            • Image-Guided Biopsy

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Giess CS et al: Ultrasound features of mammographic developing asymmetries and correlation with histopathologic findings. AJR Am J Roentgenol. 210(1):W29-W38, 2018
                                                                          2. Giess CS et al: Clinical Utility of Breast MRI in the Diagnosis of Malignancy After Inconclusive or Equivocal Mammographic Diagnostic Evaluation. AJR Am J Roentgenol. 208(6):1378-1385, 2017
                                                                          3. Chesebro AL et al: Developing Asymmetry at Mammography: Correlation with US and MR Imaging and Histopathologic Findings. Radiology. 279(2):385-94, 2016
                                                                          4. Chesebro AL et al: Developing Asymmetries at Mammography: A Multimodality Approach to Assessment and Management. Radiographics. 36(2):322-34, 2016
                                                                          5. Venkatesan A et al: Positive predictive value of specific mammographic findings according to reader and patient variables. Radiology. 250(3):648-57, 2009
                                                                          6. Youk JH et al: Asymmetric mammographic findings based on the fourth edition of BI-RADS: types, evaluation, and management. Radiographics. 29(1):e33, 2009
                                                                          7. Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
                                                                          8. Sickles EA: The spectrum of breast asymmetries: imaging features, work-up, management. Radiol Clin North Am. 45(5):765-71, v, 2007
                                                                          9. Samardar P et al: Focal asymmetric densities seen at mammography: US and pathologic correlation. Radiographics. 22(1):19-33, 2002
                                                                          10. VizcaĆ­no I et al: Short-term follow-up results in 795 nonpalpable probably benign lesions detected at screening mammography. Radiology. 219(2):475-83, 2001
                                                                          11. Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999