Nicole S. Winkler, MD; Wendie A. Berg, MD, PhD, FACR, FSBI
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Developing density, neodensity
Definitions
Developing asymmetry: Mammographic focal asymmetry (< 1 quadrant), which is new, larger, or more conspicuous than on prior examination(s)
Focal asymmetry: Compared to contralateral breast, greater amount of fibroglandular tissue over confined portion of breast (< 1 quadrant)
Visible in 2 or more projections
Concave margins; usually contains interspersed fat
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Giess CS et al: Ultrasound features of mammographic developing asymmetries and correlation with histopathologic findings. AJR Am J Roentgenol. 210(1):W29-W38, 2018
Giess CS et al: Clinical Utility of Breast MRI in the Diagnosis of Malignancy After Inconclusive or Equivocal Mammographic Diagnostic Evaluation. AJR Am J Roentgenol. 208(6):1378-1385, 2017
Chesebro AL et al: Developing Asymmetry at Mammography: Correlation with US and MR Imaging and Histopathologic Findings. Radiology. 279(2):385-94, 2016
Chesebro AL et al: Developing Asymmetries at Mammography: A Multimodality Approach to Assessment and Management. Radiographics. 36(2):322-34, 2016
Venkatesan A et al: Positive predictive value of specific mammographic findings according to reader and patient variables. Radiology. 250(3):648-57, 2009
Youk JH et al: Asymmetric mammographic findings based on the fourth edition of BI-RADS: types, evaluation, and management. Radiographics. 29(1):e33, 2009
Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
Sickles EA: The spectrum of breast asymmetries: imaging features, work-up, management. Radiol Clin North Am. 45(5):765-71, v, 2007
Samardar P et al: Focal asymmetric densities seen at mammography: US and pathologic correlation. Radiographics. 22(1):19-33, 2002
VizcaĆno I et al: Short-term follow-up results in 795 nonpalpable probably benign lesions detected at screening mammography. Radiology. 219(2):475-83, 2001
Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Developing density, neodensity
Definitions
Developing asymmetry: Mammographic focal asymmetry (< 1 quadrant), which is new, larger, or more conspicuous than on prior examination(s)
Focal asymmetry: Compared to contralateral breast, greater amount of fibroglandular tissue over confined portion of breast (< 1 quadrant)
Visible in 2 or more projections
Concave margins; usually contains interspersed fat
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Giess CS et al: Ultrasound features of mammographic developing asymmetries and correlation with histopathologic findings. AJR Am J Roentgenol. 210(1):W29-W38, 2018
Giess CS et al: Clinical Utility of Breast MRI in the Diagnosis of Malignancy After Inconclusive or Equivocal Mammographic Diagnostic Evaluation. AJR Am J Roentgenol. 208(6):1378-1385, 2017
Chesebro AL et al: Developing Asymmetry at Mammography: Correlation with US and MR Imaging and Histopathologic Findings. Radiology. 279(2):385-94, 2016
Chesebro AL et al: Developing Asymmetries at Mammography: A Multimodality Approach to Assessment and Management. Radiographics. 36(2):322-34, 2016
Venkatesan A et al: Positive predictive value of specific mammographic findings according to reader and patient variables. Radiology. 250(3):648-57, 2009
Youk JH et al: Asymmetric mammographic findings based on the fourth edition of BI-RADS: types, evaluation, and management. Radiographics. 29(1):e33, 2009
Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
Sickles EA: The spectrum of breast asymmetries: imaging features, work-up, management. Radiol Clin North Am. 45(5):765-71, v, 2007
Samardar P et al: Focal asymmetric densities seen at mammography: US and pathologic correlation. Radiographics. 22(1):19-33, 2002
VizcaĆno I et al: Short-term follow-up results in 795 nonpalpable probably benign lesions detected at screening mammography. Radiology. 219(2):475-83, 2001
Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999
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