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Diabetic Mastopathy/Lymphocytic Lobulitis
Wendie A. Berg, MD, PhD, FACR, FSBI; Wei Tse Yang, MBBS; Ray Cody Mayo, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Lymphocytic mastopathy
              • Diabetic fibrous breast disease (DFBD)
              • Diabetic fibrous mastopathy
              • Sclerosing lymphocytic lobulitis
            • Definitions

              • Periductal, perilobular, and perivascular lymphocytic infiltrate associated with dense interlobular stroma
                • Occurs primarily in women with longstanding insulin-dependent (type 1) diabetes

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • Image-Guided Biopsy

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        Selected References

                                        1. Agochukwu NB and Wong L. Diabetic mastopathy: A systematic review of surgical management of a rare breast disease. Ann Plast Surg. 78(4):471-5, 2017
                                        2. Kim J et al. Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis. Ultrasonography. 35(2):140-7, 2016
                                        3. Chen LY et al. Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast. J Clin Pathol. 69(6):527-32, 2016
                                        4. Moschetta M et al. Diabetic mastopathy: a diagnostic challenge in breast sonography. J Clin Ultrasound. 43(2):113-7, 2015
                                        5. Suvannarerg V et al: Clinical, mammographic, and ultrasonographic characteristics of diabetic mastopathy: A case series. Clin Imaging. 53:204-209, 2018
                                        6. Dorokhova O et al: Diabetic mastopathy, a clinicopathological correlation of 34 cases. Pathol Int. 62(10):660-4, 2012
                                        7. Thorncroft K et al: The diagnosis and management of diabetic mastopathy. Breast J. 13(6):607-13, 2007
                                        8. Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
                                        9. Wong KT et al: Ultrasound and MR imaging of diabetic mastopathy. Clin Radiol. 57(8):730-5, 2002
                                        10. Weinstein SP et al: Diabetic mastopathy in men: imaging findings in two patients. Radiology. 219(3):797-9, 2001
                                        11. Ely KA et al: Diabetic mastopathy. A clinicopathologic review. Am J Clin Pathol. 113(4):541-5, 2000
                                        12. Bayer U et al: Bilateral, tumorlike diabetic mastopathy-progression and regression of the disease during 5-year follow up. Eur J Radiol. 26(3):248-53, 1998
                                        13. Hunfeld KP et al: Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases. Gen Diagn Pathol. 143(1):49-58, 1997
                                        14. Lee AH et al: Sclerosing lymphocytic lobulitis in the male breast. J Clin Pathol. 49(7):609-11, 1996
                                        15. Logan WW et al: Diabetic fibrous breast disease. Radiology. 172(3):667-70, 1989
                                        16. Soler NG et al: Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus. Lancet. 1(8370):193-5, 1984
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Lymphocytic mastopathy
                                                    • Diabetic fibrous breast disease (DFBD)
                                                    • Diabetic fibrous mastopathy
                                                    • Sclerosing lymphocytic lobulitis
                                                  • Definitions

                                                    • Periductal, perilobular, and perivascular lymphocytic infiltrate associated with dense interlobular stroma
                                                      • Occurs primarily in women with longstanding insulin-dependent (type 1) diabetes

                                                  IMAGING

                                                  • General Features

                                                    • Mammographic Findings

                                                      • Ultrasonographic Findings

                                                        • MR Findings

                                                          • Image-Guided Biopsy

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Agochukwu NB and Wong L. Diabetic mastopathy: A systematic review of surgical management of a rare breast disease. Ann Plast Surg. 78(4):471-5, 2017
                                                                              2. Kim J et al. Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis. Ultrasonography. 35(2):140-7, 2016
                                                                              3. Chen LY et al. Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast. J Clin Pathol. 69(6):527-32, 2016
                                                                              4. Moschetta M et al. Diabetic mastopathy: a diagnostic challenge in breast sonography. J Clin Ultrasound. 43(2):113-7, 2015
                                                                              5. Suvannarerg V et al: Clinical, mammographic, and ultrasonographic characteristics of diabetic mastopathy: A case series. Clin Imaging. 53:204-209, 2018
                                                                              6. Dorokhova O et al: Diabetic mastopathy, a clinicopathological correlation of 34 cases. Pathol Int. 62(10):660-4, 2012
                                                                              7. Thorncroft K et al: The diagnosis and management of diabetic mastopathy. Breast J. 13(6):607-13, 2007
                                                                              8. Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
                                                                              9. Wong KT et al: Ultrasound and MR imaging of diabetic mastopathy. Clin Radiol. 57(8):730-5, 2002
                                                                              10. Weinstein SP et al: Diabetic mastopathy in men: imaging findings in two patients. Radiology. 219(3):797-9, 2001
                                                                              11. Ely KA et al: Diabetic mastopathy. A clinicopathologic review. Am J Clin Pathol. 113(4):541-5, 2000
                                                                              12. Bayer U et al: Bilateral, tumorlike diabetic mastopathy-progression and regression of the disease during 5-year follow up. Eur J Radiol. 26(3):248-53, 1998
                                                                              13. Hunfeld KP et al: Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases. Gen Diagn Pathol. 143(1):49-58, 1997
                                                                              14. Lee AH et al: Sclerosing lymphocytic lobulitis in the male breast. J Clin Pathol. 49(7):609-11, 1996
                                                                              15. Logan WW et al: Diabetic fibrous breast disease. Radiology. 172(3):667-70, 1989
                                                                              16. Soler NG et al: Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus. Lancet. 1(8370):193-5, 1984