Wendie A. Berg, MD, PhD, FACR, FSBI; Wei Tse Yang, MBBS; Ray Cody Mayo, MD
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Lymphocytic mastopathy
Diabetic fibrous breast disease (DFBD)
Diabetic fibrous mastopathy
Sclerosing lymphocytic lobulitis
Definitions
Periductal, perilobular, and perivascular lymphocytic infiltrate associated with dense interlobular stroma
Occurs primarily in women with longstanding insulin-dependent (type 1) diabetes
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Agochukwu NB and Wong L. Diabetic mastopathy: A systematic review of surgical management of a rare breast disease. Ann Plast Surg. 78(4):471-5, 2017
Kim J et al. Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis. Ultrasonography. 35(2):140-7, 2016
Chen LY et al. Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast. J Clin Pathol. 69(6):527-32, 2016
Moschetta M et al. Diabetic mastopathy: a diagnostic challenge in breast sonography. J Clin Ultrasound. 43(2):113-7, 2015
Suvannarerg V et al: Clinical, mammographic, and ultrasonographic characteristics of diabetic mastopathy: A case series. Clin Imaging. 53:204-209, 2018
Dorokhova O et al: Diabetic mastopathy, a clinicopathological correlation of 34 cases. Pathol Int. 62(10):660-4, 2012
Thorncroft K et al: The diagnosis and management of diabetic mastopathy. Breast J. 13(6):607-13, 2007
Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
Wong KT et al: Ultrasound and MR imaging of diabetic mastopathy. Clin Radiol. 57(8):730-5, 2002
Weinstein SP et al: Diabetic mastopathy in men: imaging findings in two patients. Radiology. 219(3):797-9, 2001
Ely KA et al: Diabetic mastopathy. A clinicopathologic review. Am J Clin Pathol. 113(4):541-5, 2000
Bayer U et al: Bilateral, tumorlike diabetic mastopathy-progression and regression of the disease during 5-year follow up. Eur J Radiol. 26(3):248-53, 1998
Hunfeld KP et al: Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases. Gen Diagn Pathol. 143(1):49-58, 1997
Lee AH et al: Sclerosing lymphocytic lobulitis in the male breast. J Clin Pathol. 49(7):609-11, 1996
Logan WW et al: Diabetic fibrous breast disease. Radiology. 172(3):667-70, 1989
Soler NG et al: Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus. Lancet. 1(8370):193-5, 1984
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Lymphocytic mastopathy
Diabetic fibrous breast disease (DFBD)
Diabetic fibrous mastopathy
Sclerosing lymphocytic lobulitis
Definitions
Periductal, perilobular, and perivascular lymphocytic infiltrate associated with dense interlobular stroma
Occurs primarily in women with longstanding insulin-dependent (type 1) diabetes
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Agochukwu NB and Wong L. Diabetic mastopathy: A systematic review of surgical management of a rare breast disease. Ann Plast Surg. 78(4):471-5, 2017
Kim J et al. Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis. Ultrasonography. 35(2):140-7, 2016
Chen LY et al. Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast. J Clin Pathol. 69(6):527-32, 2016
Moschetta M et al. Diabetic mastopathy: a diagnostic challenge in breast sonography. J Clin Ultrasound. 43(2):113-7, 2015
Suvannarerg V et al: Clinical, mammographic, and ultrasonographic characteristics of diabetic mastopathy: A case series. Clin Imaging. 53:204-209, 2018
Dorokhova O et al: Diabetic mastopathy, a clinicopathological correlation of 34 cases. Pathol Int. 62(10):660-4, 2012
Thorncroft K et al: The diagnosis and management of diabetic mastopathy. Breast J. 13(6):607-13, 2007
Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
Wong KT et al: Ultrasound and MR imaging of diabetic mastopathy. Clin Radiol. 57(8):730-5, 2002
Weinstein SP et al: Diabetic mastopathy in men: imaging findings in two patients. Radiology. 219(3):797-9, 2001
Ely KA et al: Diabetic mastopathy. A clinicopathologic review. Am J Clin Pathol. 113(4):541-5, 2000
Bayer U et al: Bilateral, tumorlike diabetic mastopathy-progression and regression of the disease during 5-year follow up. Eur J Radiol. 26(3):248-53, 1998
Hunfeld KP et al: Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases. Gen Diagn Pathol. 143(1):49-58, 1997
Lee AH et al: Sclerosing lymphocytic lobulitis in the male breast. J Clin Pathol. 49(7):609-11, 1996
Logan WW et al: Diabetic fibrous breast disease. Radiology. 172(3):667-70, 1989
Soler NG et al: Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus. Lancet. 1(8370):193-5, 1984
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