link
Bookmarks
Chest
Diagnosis
Airway Diseases
Emphysema and Small Airway Diseases
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH)
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH)
Melissa L. Rosado de Christenson, MD, FACR
To access 4,300 diagnoses written by the world's leading experts in radiology.
Sign in
Try it free - 15 days
0
0
0
0
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)
Neuroendocrine cell (NEC)
Definitions
NEC: Normal component of respiratory epithelium
Ability to synthesize, store, and secrete neuroamines and neuropeptides
Postulated to have chemoreceptor role (e.g., detection of tissue hypoxia)
Neuroendocrine body: Tiny NEC aggregate
NEC hyperplasia (NECH): NEC proliferation in bronchial/bronchiolar epithelium
DIPNECH: NEC proliferation associated with constrictive bronchiolitis, tumorlets, and carcinoids
Reactive NECH: Associated with chronic lung disease, may occur in response to lung injury and hypoxia
NECH near carcinoid tumors; incidental histologic finding
DIPNECH syndrome: Proposed term for symptomatic NEC proliferations and clinical constrictive bronchiolitis
IMAGING
Radiographic Findings
CT Findings
HRCT
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Carr LL et al: Diffuse Idiopathic pulmonary neuroendocrine cell hyperplasia and neuroendocrine hyperplasia of infancy. Clin Chest Med. 37(3):579-87, 2016
Rossi G et al: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia syndrome. Eur Respir J. 47(6):1829-41, 2016
Benson RE et al: Spectrum of pulmonary neuroendocrine proliferations and neoplasms. Radiographics. 33(6):1631-49, 2013
Klebe S et al: Facts and fiction: premalignant lesions of lung tissues. Pathology. 45(3):305-15, 2013
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)
Neuroendocrine cell (NEC)
Definitions
NEC: Normal component of respiratory epithelium
Ability to synthesize, store, and secrete neuroamines and neuropeptides
Postulated to have chemoreceptor role (e.g., detection of tissue hypoxia)
Neuroendocrine body: Tiny NEC aggregate
NEC hyperplasia (NECH): NEC proliferation in bronchial/bronchiolar epithelium
DIPNECH: NEC proliferation associated with constrictive bronchiolitis, tumorlets, and carcinoids
Reactive NECH: Associated with chronic lung disease, may occur in response to lung injury and hypoxia
NECH near carcinoid tumors; incidental histologic finding
DIPNECH syndrome: Proposed term for symptomatic NEC proliferations and clinical constrictive bronchiolitis
IMAGING
Radiographic Findings
CT Findings
HRCT
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Carr LL et al: Diffuse Idiopathic pulmonary neuroendocrine cell hyperplasia and neuroendocrine hyperplasia of infancy. Clin Chest Med. 37(3):579-87, 2016
Rossi G et al: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia syndrome. Eur Respir J. 47(6):1829-41, 2016
Benson RE et al: Spectrum of pulmonary neuroendocrine proliferations and neoplasms. Radiographics. 33(6):1631-49, 2013
Klebe S et al: Facts and fiction: premalignant lesions of lung tissues. Pathology. 45(3):305-15, 2013
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.
Sign in
Try it free - 15 days