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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)
- Neuroendocrine cell (NEC)
Definitions
- NEC: Normal component of respiratory epithelium
- Ability to synthesize, store, and secrete neuroamines and neuropeptides
- Postulated to have chemoreceptor role (e.g., detection of tissue hypoxia)
- Neuroendocrine body: Tiny NEC aggregate
- NEC hyperplasia (NECH): NEC proliferation in bronchial/bronchiolar epithelium
- DIPNECH: NEC proliferation associated with constrictive bronchiolitis, tumorlets, and carcinoids
- Reactive NECH: Associated with chronic lung disease, may occur in response to lung injury and hypoxia
- NECH near carcinoid tumors; incidental histologic finding
- DIPNECH syndrome: Proposed term for symptomatic NEC proliferations and clinical constrictive bronchiolitis
- NEC: Normal component of respiratory epithelium
IMAGING
Radiographic Findings
CT Findings
HRCT
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Carr LL et al: Diffuse Idiopathic pulmonary neuroendocrine cell hyperplasia and neuroendocrine hyperplasia of infancy. Clin Chest Med. 37(3):579-87, 2016
- Rossi G et al: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia syndrome. Eur Respir J. 47(6):1829-41, 2016
- Benson RE et al: Spectrum of pulmonary neuroendocrine proliferations and neoplasms. Radiographics. 33(6):1631-49, 2013
- Klebe S et al: Facts and fiction: premalignant lesions of lung tissues. Pathology. 45(3):305-15, 2013
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)
- Neuroendocrine cell (NEC)
Definitions
- NEC: Normal component of respiratory epithelium
- Ability to synthesize, store, and secrete neuroamines and neuropeptides
- Postulated to have chemoreceptor role (e.g., detection of tissue hypoxia)
- Neuroendocrine body: Tiny NEC aggregate
- NEC hyperplasia (NECH): NEC proliferation in bronchial/bronchiolar epithelium
- DIPNECH: NEC proliferation associated with constrictive bronchiolitis, tumorlets, and carcinoids
- Reactive NECH: Associated with chronic lung disease, may occur in response to lung injury and hypoxia
- NECH near carcinoid tumors; incidental histologic finding
- DIPNECH syndrome: Proposed term for symptomatic NEC proliferations and clinical constrictive bronchiolitis
- NEC: Normal component of respiratory epithelium
IMAGING
Radiographic Findings
CT Findings
HRCT
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Carr LL et al: Diffuse Idiopathic pulmonary neuroendocrine cell hyperplasia and neuroendocrine hyperplasia of infancy. Clin Chest Med. 37(3):579-87, 2016
- Rossi G et al: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia syndrome. Eur Respir J. 47(6):1829-41, 2016
- Benson RE et al: Spectrum of pulmonary neuroendocrine proliferations and neoplasms. Radiographics. 33(6):1631-49, 2013
- Klebe S et al: Facts and fiction: premalignant lesions of lung tissues. Pathology. 45(3):305-15, 2013
