Imaging diagnosis that includes multiple histologic & molecular glial tumor subtypes
Glial tumor centered in pons (WHO grades II-IV)
Expansile, often poorly marginated, typically lacks enhancement
Glioblastoma shows focal enhancement & central necrosis
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Pfaff E et al: Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience. Eur J Cancer. 114:27-35, 2019
Harward S et al: T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity. Childs Nerv Syst. 34(3):449-55, 2018
Hoffman LM et al: Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG Registries. J Clin Oncol. 36(19):1963-72, 2018
Johung TB et al: Diffuse intrinsic pontine glioma: new pathophysiological insights and emerging therapeutic targets. Curr Neuropharmacol. 15(1):88-97, 2017
Mackay A et al: Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell. 32(4):520-37.e5, 2017
Hoffman LM et al: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol Commun. 4:1, 2016
Poussaint TY et al: Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol. 18(5):725-34, 2016
Tisnado J et al: Conventional and advanced imaging of diffuse intrinsic pontine glioma. J Child Neurol. 31(12):1386-93, 2016
Buczkowicz P et al: Pathology, molecular genetics, and epigenetics of diffuse intrinsic pontine glioma. Front Oncol. 5:147, 2015
Jansen MH et al: Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria. Neuro Oncol. 17(1):160-6, 2015
Vallero SG et al: Diffuse intrinsic pontine glioma in children and adolescents: a single-center experience. Childs Nerv Syst. 30(6):1061-6, 2014
Jackson S et al: Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma. J Neurooncol. 114(3):339-44, 2013
Sedlacik J et al: MR imaging assessment of tumor perfusion and 3D segmented volume at baseline, during treatment, and at tumor progression in children with newly diagnosed diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol. 34(7):1450-5, 2013
Löbel U et al: Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol. 32(2):315-22, 2011
Sethi R et al: Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma. J Neurooncol. 102(1):121-7, 2011
Steffen-Smith EA et al: Proton magnetic resonance spectroscopy predicts survival in children with diffuse intrinsic pontine glioma. J Neurooncol. 105(2):365-73, 2011
Yamasaki F et al: Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma. Neuro Oncol. 13(7):791-801, 2011
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Diffuse intrinsic pontine glioma (DIPG)
Synonyms
Pontine glioma
Definitions
Imaging diagnosis that includes multiple histologic & molecular glial tumor subtypes
Glial tumor centered in pons (WHO grades II-IV)
Expansile, often poorly marginated, typically lacks enhancement
Glioblastoma shows focal enhancement & central necrosis
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Pfaff E et al: Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience. Eur J Cancer. 114:27-35, 2019
Harward S et al: T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity. Childs Nerv Syst. 34(3):449-55, 2018
Hoffman LM et al: Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG Registries. J Clin Oncol. 36(19):1963-72, 2018
Johung TB et al: Diffuse intrinsic pontine glioma: new pathophysiological insights and emerging therapeutic targets. Curr Neuropharmacol. 15(1):88-97, 2017
Mackay A et al: Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell. 32(4):520-37.e5, 2017
Hoffman LM et al: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol Commun. 4:1, 2016
Poussaint TY et al: Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol. 18(5):725-34, 2016
Tisnado J et al: Conventional and advanced imaging of diffuse intrinsic pontine glioma. J Child Neurol. 31(12):1386-93, 2016
Buczkowicz P et al: Pathology, molecular genetics, and epigenetics of diffuse intrinsic pontine glioma. Front Oncol. 5:147, 2015
Jansen MH et al: Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria. Neuro Oncol. 17(1):160-6, 2015
Vallero SG et al: Diffuse intrinsic pontine glioma in children and adolescents: a single-center experience. Childs Nerv Syst. 30(6):1061-6, 2014
Jackson S et al: Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma. J Neurooncol. 114(3):339-44, 2013
Sedlacik J et al: MR imaging assessment of tumor perfusion and 3D segmented volume at baseline, during treatment, and at tumor progression in children with newly diagnosed diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol. 34(7):1450-5, 2013
Löbel U et al: Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol. 32(2):315-22, 2011
Sethi R et al: Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma. J Neurooncol. 102(1):121-7, 2011
Steffen-Smith EA et al: Proton magnetic resonance spectroscopy predicts survival in children with diffuse intrinsic pontine glioma. J Neurooncol. 105(2):365-73, 2011
Yamasaki F et al: Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma. Neuro Oncol. 13(7):791-801, 2011
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