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Diffuse Leiomyomatosis
Christine O. Menias, MD; Oguz Akin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Unusual growth pattern of uterine smooth muscle proliferation resulting in diffuse enlargement of uterus

            IMAGING

            • General Features

              • Imaging Recommendations

                • Ultrasonographic Findings

                  • CT Findings

                    • MR Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Thiry T et al: Diffuse abdominopelvic leiomyomatosis: CT and MR imaging findings with histopathological correlation. Diagn Interv Imaging. 95(1):105-8, 2014
                                    2. Keskin G et al: Diffuse peritoneal leiomyomatosis. J Obstet Gynaecol. 33(5):535-6, 2013
                                    3. Agarwal K et al: Diffuse leiomyomatosis of the uterus diagnosed during pregnancy with successful vaginal delivery. Indian J Pathol Microbiol. 55(4):585-6, 2012
                                    4. Koh J et al: Uterine artery embolization (UAE) for diffuse leiomyomatosis of the uterus: clinical and imaging results. Eur J Radiol. 81(10):2726-9, 2012
                                    5. Pai D et al: Diffuse uterine leiomyomatosis in a child. Pediatr Radiol. 42(1):124-8, 2012
                                    6. Purohit R et al: A case of diffuse uterine leiomyomatosis who had two successful pregnancies after medical management. Fertil Steril. 95(7):2434, 2011
                                    7. Ip PP et al: Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol. 17(2):91-112, 2010
                                    8. Coskun A et al: A case with diffuse uterine leiomyomatosis and review of the literature. Clin Exp Obstet Gynecol. 35(3):227-30, 2008
                                    9. Scheurig C et al: Uterine artery embolization in patients with symptomatic diffuse leiomyomatosis of the uterus. J Vasc Interv Radiol. 19(2 Pt 1):279-84, 2008
                                    10. Cohen DT et al: Uterine smooth-muscle tumors with unusual growth patterns: imaging with pathologic correlation. AJR Am J Roentgenol. 188(1):246-55, 2007
                                    11. Thomas EO et al: Diffuse uterine leiomyomatosis with uterine rupture and benign metastatic lesions of the bone. Obstet Gynecol. 109:528-30, 2007
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Definitions

                                                • Unusual growth pattern of uterine smooth muscle proliferation resulting in diffuse enlargement of uterus

                                              IMAGING

                                              • General Features

                                                • Imaging Recommendations

                                                  • Ultrasonographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Thiry T et al: Diffuse abdominopelvic leiomyomatosis: CT and MR imaging findings with histopathological correlation. Diagn Interv Imaging. 95(1):105-8, 2014
                                                                      2. Keskin G et al: Diffuse peritoneal leiomyomatosis. J Obstet Gynaecol. 33(5):535-6, 2013
                                                                      3. Agarwal K et al: Diffuse leiomyomatosis of the uterus diagnosed during pregnancy with successful vaginal delivery. Indian J Pathol Microbiol. 55(4):585-6, 2012
                                                                      4. Koh J et al: Uterine artery embolization (UAE) for diffuse leiomyomatosis of the uterus: clinical and imaging results. Eur J Radiol. 81(10):2726-9, 2012
                                                                      5. Pai D et al: Diffuse uterine leiomyomatosis in a child. Pediatr Radiol. 42(1):124-8, 2012
                                                                      6. Purohit R et al: A case of diffuse uterine leiomyomatosis who had two successful pregnancies after medical management. Fertil Steril. 95(7):2434, 2011
                                                                      7. Ip PP et al: Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol. 17(2):91-112, 2010
                                                                      8. Coskun A et al: A case with diffuse uterine leiomyomatosis and review of the literature. Clin Exp Obstet Gynecol. 35(3):227-30, 2008
                                                                      9. Scheurig C et al: Uterine artery embolization in patients with symptomatic diffuse leiomyomatosis of the uterus. J Vasc Interv Radiol. 19(2 Pt 1):279-84, 2008
                                                                      10. Cohen DT et al: Uterine smooth-muscle tumors with unusual growth patterns: imaging with pathologic correlation. AJR Am J Roentgenol. 188(1):246-55, 2007
                                                                      11. Thomas EO et al: Diffuse uterine leiomyomatosis with uterine rupture and benign metastatic lesions of the bone. Obstet Gynecol. 109:528-30, 2007