link
Bookmarks
Diffuse Midline Glioma, H3K27M-Mutant
Miral D. Jhaveri, MD, MBA
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
10
9
6

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Diffuse midline glioma H3K27M-mutant (DMG)
                • Diffuse intrinsic pontine glioma (DIPG)
              • Definitions

                • Infiltrative, midline, high-grade glioma with predominantly astrocytic differentiation and K27M mutation in histone H3 gene
                  • New entity in 2016 WHO classification of tumors of CNS
                  • Brainstem and pontine examples previously known as brainstem glioma and DIPG, respectively

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Dufour C et al: Identification of prognostic markers in diffuse midline gliomas H3K27M-mutant. Brain Pathol. 30(1):17990, 2020
                                          2. Enomoto T et al: Midline glioma in adults: clinicopathological, genetic, and epigenetic analysis. Neurol Med Chir (Tokyo). 60(3):136-46, 2020
                                          3. Wierzbicki K et al: Targeting and therapeutic monitoring of H3K27M-mutant glioma. Curr Oncol Rep. 22(2):19, 2020
                                          4. Williams JR et al: Progress in diffuse intrinsic pontine glioma: advocating for stereotactic biopsy in the standard of care. Neurosurg Focus. 48(1):E4, 2020
                                          5. Yekula A et al: Adult H3K27M-mutant diffuse midline glioma with gliomatosis cerebri growth pattern: Case report and review of the literature. Int J Surg Case Rep. 68:124-8, 2020
                                          6. Aboian MS et al: Diffusion Characteristics of pediatric diffuse midline gliomas with histone H3-K27M mutation using apparent diffusion coefficient histogram analysis. AJNR Am J Neuroradiol. 40(11):1804-10, 2019
                                          7. Piccardo A et al: Advanced MR imaging and 18F-DOPA PET characteristics of H3K27M-mutant and wild-type pediatric diffuse midline gliomas. Eur J Nucl Med Mol Imaging. 46(8):1685-94, 2019
                                          8. Aboian MS et al: Imaging characteristics of pediatric diffuse midline gliomas with histone H3 K27M mutation. AJNR Am J Neuroradiol. 38(4):795-800, 2017
                                          Related Anatomy
                                          Loading...
                                          Related Differential Diagnoses
                                          Loading...
                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Diffuse midline glioma H3K27M-mutant (DMG)
                                                        • Diffuse intrinsic pontine glioma (DIPG)
                                                      • Definitions

                                                        • Infiltrative, midline, high-grade glioma with predominantly astrocytic differentiation and K27M mutation in histone H3 gene
                                                          • New entity in 2016 WHO classification of tumors of CNS
                                                          • Brainstem and pontine examples previously known as brainstem glioma and DIPG, respectively

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Dufour C et al: Identification of prognostic markers in diffuse midline gliomas H3K27M-mutant. Brain Pathol. 30(1):17990, 2020
                                                                                  2. Enomoto T et al: Midline glioma in adults: clinicopathological, genetic, and epigenetic analysis. Neurol Med Chir (Tokyo). 60(3):136-46, 2020
                                                                                  3. Wierzbicki K et al: Targeting and therapeutic monitoring of H3K27M-mutant glioma. Curr Oncol Rep. 22(2):19, 2020
                                                                                  4. Williams JR et al: Progress in diffuse intrinsic pontine glioma: advocating for stereotactic biopsy in the standard of care. Neurosurg Focus. 48(1):E4, 2020
                                                                                  5. Yekula A et al: Adult H3K27M-mutant diffuse midline glioma with gliomatosis cerebri growth pattern: Case report and review of the literature. Int J Surg Case Rep. 68:124-8, 2020
                                                                                  6. Aboian MS et al: Diffusion Characteristics of pediatric diffuse midline gliomas with histone H3-K27M mutation using apparent diffusion coefficient histogram analysis. AJNR Am J Neuroradiol. 40(11):1804-10, 2019
                                                                                  7. Piccardo A et al: Advanced MR imaging and 18F-DOPA PET characteristics of H3K27M-mutant and wild-type pediatric diffuse midline gliomas. Eur J Nucl Med Mol Imaging. 46(8):1685-94, 2019
                                                                                  8. Aboian MS et al: Imaging characteristics of pediatric diffuse midline gliomas with histone H3 K27M mutation. AJNR Am J Neuroradiol. 38(4):795-800, 2017