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Diffuse Panbronchiolitis
Kyung Soo Lee, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Diffuse panbronchiolitis (DPB)
              • Definitions

                • Rare syndrome of unknown etiology characterized by cellular bronchiolitis and chronic sinusitis
                  • Diffuse: Bilateral lung involvement
                  • Panbronchiolitis: Involves all layers of respiratory bronchiole wall
                  • Characterized by accumulation of foamy macrophages in respiratory bronchiolar walls and alveolar ducts

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Sugimoto S et al: Lung transplantation for diffuse panbronchiolitis: 5 cases from a single centre. Interact Cardiovasc Thorac Surg. 22(5):679-81, 2016
                                        2. Tsuji T et al: Nontuberculous mycobacteria in diffuse panbronchiolitis. Respirology. 20(1):80-6, 2015
                                        3. Kudoh S et al: Diffuse panbronchiolitis. Clin Chest Med. 33(2):297-305, 2012
                                        4. Anthony M et al: Diffuse panbronchiolitis: not just an Asian disease: Australian case series and review of the literature. Biomed Imaging Interv J. 5(4):e19, 2009
                                        5. Poletti V et al: Diffuse panbronchiolitis. Eur Respir J. 28(4):862-71, 2006
                                        6. Park MH et al: Association of HLA class I antigens with diffuse panbronchiolitis in Korean patients. Am J Respir Crit Care Med. 159(2):526-9, 1999
                                        7. Fitzgerald JE et al: Diffuse panbronchiolitis in the United States. Am J Respir Crit Care Med. 154(2 Pt 1):497-503, 1996
                                        8. Akira M et al: Diffuse panbronchiolitis: follow-up CT examination. Radiology. 189(2):559-62, 1993
                                        9. Nishimura K et al: Diffuse panbronchiolitis: correlation of high-resolution CT and pathologic findings. Radiology. 184(3):779-85, 1992
                                        10. Sugiyama Y et al: Analysis of HLA antigens in patients with diffuse panbronchiolitis. Am Rev Respir Dis. 141(6):1459-62, 1990
                                        11. Akira M et al: Diffuse panbronchiolitis: evaluation with high-resolution CT. Radiology. 168(2):433-8, 1988
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Diffuse panbronchiolitis (DPB)
                                                    • Definitions

                                                      • Rare syndrome of unknown etiology characterized by cellular bronchiolitis and chronic sinusitis
                                                        • Diffuse: Bilateral lung involvement
                                                        • Panbronchiolitis: Involves all layers of respiratory bronchiole wall
                                                        • Characterized by accumulation of foamy macrophages in respiratory bronchiolar walls and alveolar ducts

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Sugimoto S et al: Lung transplantation for diffuse panbronchiolitis: 5 cases from a single centre. Interact Cardiovasc Thorac Surg. 22(5):679-81, 2016
                                                                              2. Tsuji T et al: Nontuberculous mycobacteria in diffuse panbronchiolitis. Respirology. 20(1):80-6, 2015
                                                                              3. Kudoh S et al: Diffuse panbronchiolitis. Clin Chest Med. 33(2):297-305, 2012
                                                                              4. Anthony M et al: Diffuse panbronchiolitis: not just an Asian disease: Australian case series and review of the literature. Biomed Imaging Interv J. 5(4):e19, 2009
                                                                              5. Poletti V et al: Diffuse panbronchiolitis. Eur Respir J. 28(4):862-71, 2006
                                                                              6. Park MH et al: Association of HLA class I antigens with diffuse panbronchiolitis in Korean patients. Am J Respir Crit Care Med. 159(2):526-9, 1999
                                                                              7. Fitzgerald JE et al: Diffuse panbronchiolitis in the United States. Am J Respir Crit Care Med. 154(2 Pt 1):497-503, 1996
                                                                              8. Akira M et al: Diffuse panbronchiolitis: follow-up CT examination. Radiology. 189(2):559-62, 1993
                                                                              9. Nishimura K et al: Diffuse panbronchiolitis: correlation of high-resolution CT and pathologic findings. Radiology. 184(3):779-85, 1992
                                                                              10. Sugiyama Y et al: Analysis of HLA antigens in patients with diffuse panbronchiolitis. Am Rev Respir Dis. 141(6):1459-62, 1990
                                                                              11. Akira M et al: Diffuse panbronchiolitis: evaluation with high-resolution CT. Radiology. 168(2):433-8, 1988