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Diffuse-Type Giant Cell Tumor (Extraarticular PVNS)
Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Extraarticular pigmented villonodular synovitis (PVNS), tenosynovial giant cell tumor (diffuse type), proliferative synovitis, florid synovitis
        • Definitions

          • Uncommon, rarely metastasizing fibrohistiocytic tumor representing extraarticular soft tissue form of PVNS

        IMAGING

        • General Features

          • CT Findings

            • MR Findings

              • Nuclear Medicine Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Staging, Grading, & Classification

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Righi A et al: Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. Clin Sarcoma Res. 5:15, 2015
                                  2. van der Heijden L et al: Functional outcome and quality of life after the surgical treatment for diffuse-type giant-cell tumour around the knee: a retrospective analysis of 30 patients. Bone Joint J. 96-B(8):1111-8, 2014
                                  3. Wang K et al: Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature. Turk Neurosurg. 24(5):804-13, 2014
                                  4. Yun SJ et al: Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. Skeletal Radiol. 43(8):1179-83, 2014
                                  5. Weiss SW et al: Benign tumors and tumor-like lesions of synovial tissue. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 777-782, 2008
                                  6. Masuzawa N et al: Extraarticular paravertebral diffuse-type giant cell tumor. Skeletal Radiol. 36(4):321-5, 2007
                                  7. Sanghvi DA et al: Diffuse-type giant cell tumor of the subcutaneous thigh. Skeletal Radiol. 36(4):327-30, 2007
                                  8. Yoshida T et al: Intramuscular diffuse-type giant cell tumor within the hamstring muscle. Skeletal Radiol. 36(4):331-3, 2007
                                  9. Kransdorf MJ et al: Synovial tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 382-5, 2006
                                  10. Posligua L et al: Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. Am J Surg Pathol. 30(6):734-8, 2006
                                  11. Somerhausen NS et al: Diffuse-type giant cell tumour. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 112-4, 2002
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Synonyms

                                          • Extraarticular pigmented villonodular synovitis (PVNS), tenosynovial giant cell tumor (diffuse type), proliferative synovitis, florid synovitis
                                        • Definitions

                                          • Uncommon, rarely metastasizing fibrohistiocytic tumor representing extraarticular soft tissue form of PVNS

                                        IMAGING

                                        • General Features

                                          • CT Findings

                                            • MR Findings

                                              • Nuclear Medicine Findings

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Staging, Grading, & Classification

                                                      • Gross Pathologic & Surgical Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Righi A et al: Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. Clin Sarcoma Res. 5:15, 2015
                                                                  2. van der Heijden L et al: Functional outcome and quality of life after the surgical treatment for diffuse-type giant-cell tumour around the knee: a retrospective analysis of 30 patients. Bone Joint J. 96-B(8):1111-8, 2014
                                                                  3. Wang K et al: Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature. Turk Neurosurg. 24(5):804-13, 2014
                                                                  4. Yun SJ et al: Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. Skeletal Radiol. 43(8):1179-83, 2014
                                                                  5. Weiss SW et al: Benign tumors and tumor-like lesions of synovial tissue. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 777-782, 2008
                                                                  6. Masuzawa N et al: Extraarticular paravertebral diffuse-type giant cell tumor. Skeletal Radiol. 36(4):321-5, 2007
                                                                  7. Sanghvi DA et al: Diffuse-type giant cell tumor of the subcutaneous thigh. Skeletal Radiol. 36(4):327-30, 2007
                                                                  8. Yoshida T et al: Intramuscular diffuse-type giant cell tumor within the hamstring muscle. Skeletal Radiol. 36(4):331-3, 2007
                                                                  9. Kransdorf MJ et al: Synovial tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 382-5, 2006
                                                                  10. Posligua L et al: Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. Am J Surg Pathol. 30(6):734-8, 2006
                                                                  11. Somerhausen NS et al: Diffuse-type giant cell tumour. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 112-4, 2002