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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Dysembryoplastic neuroepithelial tumor (DNET)
Definitions
- Benign, mixed glial-neuronal neoplasm
- Epileptogenic tumor often associated with cortical dysplasia
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Zamora C et al: Supratentorial tumors in pediatric patients. Neuroimaging Clin N Am. 27(1):39-67, 2017
- Ranger A et al: Seizures in children with dysembryoplastic neuroepithelial tumors of the brain-a review of surgical outcomes across several studies. Childs Nerv Syst. 31(6):847-55, 2015
- Kim AH et al: Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging. J Neurosurg Pediatr. 14(4):356-64, 2014
- Lee D et al: BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas. J Surg Oncol. 111(3):359-64, 2014
- Chuang NA et al: Glioblastoma multiforme arising from dysembryoplastic neuroepithelial tumor in a child in the absence of therapy. J Pediatr Hematol Oncol. 36(8):e536-9, 2013
- Daghistani R et al: Atypical characteristics and behavior of dysembryoplastic neuroepithelial tumors. Neuroradiology. 55(2):217-24, 2013
- Shinoda J et al: Epilepsy surgery of dysembryoplastic neuroepithelial tumors using advanced multitechnologies with combined neuroimaging and electrophysiological examinations. Epilepsy Behav Case Rep. 1:97-105, 2013
- Chassoux F et al: Dysembryoplastic neuroepithelial tumors: an MRI-based scheme for epilepsy surgery. Neurology. 79(16):1699-707, 2012
- Thom M et al: One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. J Neuropathol Exp Neurol. 70(10):859-78, 2011
- Bilginer B et al: Surgery for epilepsy in children with dysembryoplastic neuroepithelial tumor: clinical spectrum, seizure outcome, neuroradiology, and pathology. Childs Nerv Syst. 25(4):485-91, 2009
- Campos AR et al: Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology. Neuroradiology. 51(7):433-43, 2009
- Lee J et al: Dysembryoplastic neuroepithelial tumors in pediatric patients. Brain Dev. 31(9):671-81, 2009
- Ray WZ et al: Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature. J Neurooncol. 94(2):283-92, 2009
- Bulakbasi N et al: Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics. Neuroradiology. 49(10):805-12, 2007
- Parmar HA et al: Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors. J Comput Assist Tomogr. 31(3):348-53, 2007
- Maehara T et al: Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy. Epilepsia. 45(1):41-5, 2004
- Vuori K et al: Low-grade gliomas and focal cortical developmental malformations: differentiation with proton MR spectroscopy. Radiology. 230(3):703-8, 2004
- Fernandez C et al: The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases. AJNR Am J Neuroradiol. 24(5):829-34, 2003
- Stanescu Cosson R et al: Dysembryoplastic neuroepithelial tumors: CT, MR findings and imaging follow-up: a study of 53 cases. J Neuroradiol. 28(4):230-40, 2001
- Honavar M et al: Histological heterogeneity of dysembryoplastic neuroepithelial tumour: identification and differential diagnosis in a series of 74 cases. Histopathology. 34(4):342-56, 1999
- Thom M et al: Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases. J Neurol Neurosurg Psychiatry. 67(1):97-101, 1999
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Dysembryoplastic neuroepithelial tumor (DNET)
Definitions
- Benign, mixed glial-neuronal neoplasm
- Epileptogenic tumor often associated with cortical dysplasia
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Zamora C et al: Supratentorial tumors in pediatric patients. Neuroimaging Clin N Am. 27(1):39-67, 2017
- Ranger A et al: Seizures in children with dysembryoplastic neuroepithelial tumors of the brain-a review of surgical outcomes across several studies. Childs Nerv Syst. 31(6):847-55, 2015
- Kim AH et al: Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging. J Neurosurg Pediatr. 14(4):356-64, 2014
- Lee D et al: BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas. J Surg Oncol. 111(3):359-64, 2014
- Chuang NA et al: Glioblastoma multiforme arising from dysembryoplastic neuroepithelial tumor in a child in the absence of therapy. J Pediatr Hematol Oncol. 36(8):e536-9, 2013
- Daghistani R et al: Atypical characteristics and behavior of dysembryoplastic neuroepithelial tumors. Neuroradiology. 55(2):217-24, 2013
- Shinoda J et al: Epilepsy surgery of dysembryoplastic neuroepithelial tumors using advanced multitechnologies with combined neuroimaging and electrophysiological examinations. Epilepsy Behav Case Rep. 1:97-105, 2013
- Chassoux F et al: Dysembryoplastic neuroepithelial tumors: an MRI-based scheme for epilepsy surgery. Neurology. 79(16):1699-707, 2012
- Thom M et al: One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. J Neuropathol Exp Neurol. 70(10):859-78, 2011
- Bilginer B et al: Surgery for epilepsy in children with dysembryoplastic neuroepithelial tumor: clinical spectrum, seizure outcome, neuroradiology, and pathology. Childs Nerv Syst. 25(4):485-91, 2009
- Campos AR et al: Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology. Neuroradiology. 51(7):433-43, 2009
- Lee J et al: Dysembryoplastic neuroepithelial tumors in pediatric patients. Brain Dev. 31(9):671-81, 2009
- Ray WZ et al: Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature. J Neurooncol. 94(2):283-92, 2009
- Bulakbasi N et al: Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics. Neuroradiology. 49(10):805-12, 2007
- Parmar HA et al: Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors. J Comput Assist Tomogr. 31(3):348-53, 2007
- Maehara T et al: Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy. Epilepsia. 45(1):41-5, 2004
- Vuori K et al: Low-grade gliomas and focal cortical developmental malformations: differentiation with proton MR spectroscopy. Radiology. 230(3):703-8, 2004
- Fernandez C et al: The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases. AJNR Am J Neuroradiol. 24(5):829-34, 2003
- Stanescu Cosson R et al: Dysembryoplastic neuroepithelial tumors: CT, MR findings and imaging follow-up: a study of 53 cases. J Neuroradiol. 28(4):230-40, 2001
- Honavar M et al: Histological heterogeneity of dysembryoplastic neuroepithelial tumour: identification and differential diagnosis in a series of 74 cases. Histopathology. 34(4):342-56, 1999
- Thom M et al: Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases. J Neurol Neurosurg Psychiatry. 67(1):97-101, 1999
