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Drug-Induced Esophagitis
Atif Zaheer, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Drug-induced esophagitis (DIE)
          • Synonyms

            • Pill-induced, medication-induced esophagitis
          • Definitions

            • Esophageal injury induced by direct contact with oral medications
          • Clinical Presentation

            • Patient wakes up with severe odynophagia in morning after taking medications just before bedtime

          IMAGING

          • General Features

            • Radiographic Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Presentation

                      • Natural History & Prognosis

                        • Treatment

                          Selected References

                          1. Saleem F et al: Drug induced esophagitis. In: StatPearls [Internet]. StatPearls Publishing, 2021
                          2. Apostolov R et al: A difficult pill to swallow: drug-induced oesophagitis. Lancet. 394(10210):1764, 2019
                          3. De Petris G et al: Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II). Int J Surg Pathol. 22(3):202-11, 2014
                          4. Guttman OR et al: Drug-induced esophageal injury with an occult vascular ring. Paediatr Child Health. 16(9):554-6, 2011
                          5. Geagea A et al: Scope of drug-induced, infectious and allergic esophageal injury. Curr Opin Gastroenterol. 24(4):496-501, 2008
                          6. McCullough RW et al: Pill-induced esophagitis complicated by multiple esophageal septa. Gastrointest Endosc. 59(1):150-2, 2004
                          7. O'Neill JL et al: Drug-induced esophageal injuries and dysphagia. Ann Pharmacother. 37(11):1675-84, 2003
                          8. Levine MS: Drug-induced disorders of the esophagus. Abdom Imaging. 24(1):3-8, 1999
                          Related Anatomy
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                          Related Differential Diagnoses
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                          References
                          Tables

                          Tables

                          KEY FACTS

                          • Terminology

                            • Imaging

                              • Top Differential Diagnoses

                                • Clinical Issues

                                  TERMINOLOGY

                                  • Abbreviations

                                    • Drug-induced esophagitis (DIE)
                                  • Synonyms

                                    • Pill-induced, medication-induced esophagitis
                                  • Definitions

                                    • Esophageal injury induced by direct contact with oral medications
                                  • Clinical Presentation

                                    • Patient wakes up with severe odynophagia in morning after taking medications just before bedtime

                                  IMAGING

                                  • General Features

                                    • Radiographic Findings

                                      • Imaging Recommendations

                                        DIFFERENTIAL DIAGNOSIS

                                          PATHOLOGY

                                          • General Features

                                            CLINICAL ISSUES

                                            • Presentation

                                              • Natural History & Prognosis

                                                • Treatment

                                                  Selected References

                                                  1. Saleem F et al: Drug induced esophagitis. In: StatPearls [Internet]. StatPearls Publishing, 2021
                                                  2. Apostolov R et al: A difficult pill to swallow: drug-induced oesophagitis. Lancet. 394(10210):1764, 2019
                                                  3. De Petris G et al: Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II). Int J Surg Pathol. 22(3):202-11, 2014
                                                  4. Guttman OR et al: Drug-induced esophageal injury with an occult vascular ring. Paediatr Child Health. 16(9):554-6, 2011
                                                  5. Geagea A et al: Scope of drug-induced, infectious and allergic esophageal injury. Curr Opin Gastroenterol. 24(4):496-501, 2008
                                                  6. McCullough RW et al: Pill-induced esophagitis complicated by multiple esophageal septa. Gastrointest Endosc. 59(1):150-2, 2004
                                                  7. O'Neill JL et al: Drug-induced esophageal injuries and dysphagia. Ann Pharmacother. 37(11):1675-84, 2003
                                                  8. Levine MS: Drug-induced disorders of the esophagus. Abdom Imaging. 24(1):3-8, 1999