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Drug-Induced Lung Disease
Sonia L. Betancourt Cuellar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Drug-induced lung disease (DILD)
            • Synonyms

              • Drug-induced lung injury
            • Definitions

              • DILD consists of lung reaction to a variety of drugs and exhibits multiple histologic patterns
                • Common drugs: Reported with antibiotics, cardiovascular drugs, antiinflammatory drugs, anticonvulsants, chemotherapy agents, and recreational drugs

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
                                          2. Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
                                          3. Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
                                          4. Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
                                          5. Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
                                          6. Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
                                          7. Vahid B et al: Pulmonary complications of novel antineoplastic agents for solid tumors. Chest. 133(2):528-38, 2008
                                          8. Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008
                                          9. Camus P et al: Interstitial lung disease associated with drug therapy. Br J Cancer. 91 Suppl 2:S18-23, 2004
                                          10. Takano T et al: Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib. Lung Cancer. 45(1):93-104, 2004
                                          11. Rossi SE et al: Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographs 20:1245-59, 2000
                                          12. Rosenow EC 3rd et al: Drug-induced pulmonary disease. Semin Respir Infect. 10(2):86-95, 1995
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Drug-induced lung disease (DILD)
                                                    • Synonyms

                                                      • Drug-induced lung injury
                                                    • Definitions

                                                      • DILD consists of lung reaction to a variety of drugs and exhibits multiple histologic patterns
                                                        • Common drugs: Reported with antibiotics, cardiovascular drugs, antiinflammatory drugs, anticonvulsants, chemotherapy agents, and recreational drugs

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
                                                                                  2. Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
                                                                                  3. Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
                                                                                  4. Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
                                                                                  5. Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
                                                                                  6. Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
                                                                                  7. Vahid B et al: Pulmonary complications of novel antineoplastic agents for solid tumors. Chest. 133(2):528-38, 2008
                                                                                  8. Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008
                                                                                  9. Camus P et al: Interstitial lung disease associated with drug therapy. Br J Cancer. 91 Suppl 2:S18-23, 2004
                                                                                  10. Takano T et al: Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib. Lung Cancer. 45(1):93-104, 2004
                                                                                  11. Rossi SE et al: Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographs 20:1245-59, 2000
                                                                                  12. Rosenow EC 3rd et al: Drug-induced pulmonary disease. Semin Respir Infect. 10(2):86-95, 1995