DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
Most commonly reported drugs: Antineoplastic, antiinflammatory, cardiovascular agents, antibiotics
Others: Anticonvulsants and recreational drugs
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Terbuch A et al: Radiological patterns of drug-induced interstitial lung disease (DILD) in early-phase oncology clinical trials. Clin Cancer Res. 26(18):4805-13, 2020
Roden AC et al: Iatrogenic pulmonary lesions. Semin Diagn Pathol. 35(4):260-71, 2018
Skeoch S et al: Drug-induced interstitial lung disease: a systematic review. J Clin Med. 7(10), 2018
Nishino M et al: Thoracic complications of precision cancer therapies: a practical guide for radiologists in the new era of cancer care. Radiographics. 37(5):1371-87, 2017
Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Drug-induced lung disease (DILD)
Synonyms
Drug-induced lung injury
Definitions
DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
Most commonly reported drugs: Antineoplastic, antiinflammatory, cardiovascular agents, antibiotics
Others: Anticonvulsants and recreational drugs
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Terbuch A et al: Radiological patterns of drug-induced interstitial lung disease (DILD) in early-phase oncology clinical trials. Clin Cancer Res. 26(18):4805-13, 2020
Roden AC et al: Iatrogenic pulmonary lesions. Semin Diagn Pathol. 35(4):260-71, 2018
Skeoch S et al: Drug-induced interstitial lung disease: a systematic review. J Clin Med. 7(10), 2018
Nishino M et al: Thoracic complications of precision cancer therapies: a practical guide for radiologists in the new era of cancer care. Radiographics. 37(5):1371-87, 2017
Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008
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