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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Drug-induced lung disease (DILD)
Synonyms
- Drug-induced lung injury
Definitions
- DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
- Most commonly reported drugs: Antineoplastic, antiinflammatory, cardiovascular agents, antibiotics
- Others: Anticonvulsants and recreational drugs
- DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Terbuch A et al: Radiological patterns of drug-induced interstitial lung disease (DILD) in early-phase oncology clinical trials. Clin Cancer Res. 26(18):4805-13, 2020
- Roden AC et al: Iatrogenic pulmonary lesions. Semin Diagn Pathol. 35(4):260-71, 2018
- Skeoch S et al: Drug-induced interstitial lung disease: a systematic review. J Clin Med. 7(10), 2018
- Nishino M et al: Thoracic complications of precision cancer therapies: a practical guide for radiologists in the new era of cancer care. Radiographics. 37(5):1371-87, 2017
- Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
- Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
- Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
- Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
- Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
- Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
- Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Drug-induced lung disease (DILD)
Synonyms
- Drug-induced lung injury
Definitions
- DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
- Most commonly reported drugs: Antineoplastic, antiinflammatory, cardiovascular agents, antibiotics
- Others: Anticonvulsants and recreational drugs
- DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Terbuch A et al: Radiological patterns of drug-induced interstitial lung disease (DILD) in early-phase oncology clinical trials. Clin Cancer Res. 26(18):4805-13, 2020
- Roden AC et al: Iatrogenic pulmonary lesions. Semin Diagn Pathol. 35(4):260-71, 2018
- Skeoch S et al: Drug-induced interstitial lung disease: a systematic review. J Clin Med. 7(10), 2018
- Nishino M et al: Thoracic complications of precision cancer therapies: a practical guide for radiologists in the new era of cancer care. Radiographics. 37(5):1371-87, 2017
- Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
- Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
- Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
- Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
- Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
- Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
- Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008
