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Drug Reaction, Intrathoracic
Sonia L. Betancourt-Cuellar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Drug-induced lung disease (DILD)
            • Synonyms

              • Drug-induced lung injury
            • Definitions

              • DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
                • Most commonly reported drugs: Antineoplastic, antiinflammatory, cardiovascular agents, antibiotics
                • Others: Anticonvulsants and recreational drugs

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Terbuch A et al: Radiological patterns of drug-induced interstitial lung disease (DILD) in early-phase oncology clinical trials. Clin Cancer Res. 26(18):4805-13, 2020
                                          2. Roden AC et al: Iatrogenic pulmonary lesions. Semin Diagn Pathol. 35(4):260-71, 2018
                                          3. Skeoch S et al: Drug-induced interstitial lung disease: a systematic review. J Clin Med. 7(10), 2018
                                          4. Nishino M et al: Thoracic complications of precision cancer therapies: a practical guide for radiologists in the new era of cancer care. Radiographics. 37(5):1371-87, 2017
                                          5. Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
                                          6. Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
                                          7. Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
                                          8. Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
                                          9. Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
                                          10. Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
                                          11. Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Drug-induced lung disease (DILD)
                                                    • Synonyms

                                                      • Drug-induced lung injury
                                                    • Definitions

                                                      • DILD: Drug exposure that causes inflammation, which may resolve or evolve to fibrosis
                                                        • Most commonly reported drugs: Antineoplastic, antiinflammatory, cardiovascular agents, antibiotics
                                                        • Others: Anticonvulsants and recreational drugs

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Terbuch A et al: Radiological patterns of drug-induced interstitial lung disease (DILD) in early-phase oncology clinical trials. Clin Cancer Res. 26(18):4805-13, 2020
                                                                                  2. Roden AC et al: Iatrogenic pulmonary lesions. Semin Diagn Pathol. 35(4):260-71, 2018
                                                                                  3. Skeoch S et al: Drug-induced interstitial lung disease: a systematic review. J Clin Med. 7(10), 2018
                                                                                  4. Nishino M et al: Thoracic complications of precision cancer therapies: a practical guide for radiologists in the new era of cancer care. Radiographics. 37(5):1371-87, 2017
                                                                                  5. Carter BW et al: Acute thoracic findings in oncologic patients. J Thorac Imaging. 30(4): 233-56, 2015
                                                                                  6. Essaadouni L et al: [Drug induced interstitial lung disease in systemic diseases.] Rev Pneumol Clin. 69(6):307-14, 2013
                                                                                  7. Tamura M et al: High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases. Oncologist. 18(4):454-9, 2013
                                                                                  8. Iacovelli R et al: Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials. Acta Oncol. 51(7):873-9, 2012
                                                                                  9. Matsuno O: Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 13:39, 2012
                                                                                  10. Torrisi JM et al: CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology. 258(1):41-56, 2011
                                                                                  11. Yamane T et al: Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 22(8):719-22, 2008