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Gastrointestinal
Diagnosis
Duodenum
Malignant Neoplasms
Duodenal Carcinoma
Duodenal Carcinoma
Atif Zaheer, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Duodenal carcinoma (CA)

            • Synonyms

              • Duodenal adenocarcinoma

            • Definitions

              • Primary malignant neoplasm arising in duodenal mucosa

            IMAGING

            • General Features

              • Radiographic Findings

                • Fluoroscopic Findings

                  • CT Findings

                    • MR Findings

                      • Ultrasonographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Zhu Z et al: Comparative analysis of outcomes and clinicopathological characteristics of duodenal adenocarcinoma: a SEER analysis. Cancer Invest. 1-16, 2020
                                                2. Cloyd JM et al: Duodenal adenocarcinoma: advances in diagnosis and surgical management. World J Gastrointest Surg. 8(3):212-21, 2016
                                                3. Qureshi S et al: Malignant pyloro-duodenal obstruction: role of self expandable metallic stents. J Pak Med Assoc. 64(1):16-9, 2014
                                                4. Wood LD et al: Upper GI tract lesions in familial adenomatous polyposis (FAP): enrichment of pyloric gland adenomas and other gastric and duodenal neoplasms. Am J Surg Pathol. 38(3):389-93, 2014
                                                5. Struck A et al: Non-ampullary duodenal adenocarcinoma: factors important for relapse and survival. J Surg Oncol. 100(2):144-8, 2009
                                                6. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                                7. Lawler LP et al: Peripancreatic masses that simulate pancreatic disease: spectrum of disease and role of CT. Radiographics. 23(5):1117-31, 2003
                                                8. Kim JH et al: Differential diagnosis of periampullary carcinomas at MR imaging. Radiographics. 22(6):1335-52, 2002
                                                9. Korman MU: Radiologic evaluation and staging of small intestine neoplasms. Eur J Radiol. 42(3):193-205, 2002
                                                10. Iki K et al: Primary adenocarcinoma of the duodenum demonstrated by ultrasonography. J Gastroenterol. 36(3):195-9, 2001
                                                11. Ishida H et al: Duodenal carcinoma: sonographic findings. Abdom Imaging. 26(5):469-73, 2001
                                                12. Nagi B et al: Primary small bowel tumors: a radiologic-pathologic correlation. Abdom Imaging. 26(5):474-80, 2001
                                                13. Gore R et al: Textbook of Gastrointestinal Radiology. 2nd ed. Philadelphia, W.B. Saunders, 1980-1992, 2000
                                                14. Buckley JA et al: CT evaluation of small bowel neoplasms: spectrum of disease. Radiographics. 18(2):379-92, 1998
                                                15. Neugut AI et al: The epidemiology of cancer of the small bowel. Cancer Epidemiol Biomarkers Prev. 7(3):243-51, 1998
                                                16. Arber N et al: Molecular genetics of small bowel cancer. Cancer Epidemiol Biomarkers Prev. 6(9):745-8, 1997
                                                17. Buckley JA et al: Small bowel cancer. Imaging features and staging. Radiol Clin North Am. 35(2):381-402, 1997
                                                18. Buckley JA et al: The accuracy of CT staging of small bowel adenocarcinoma: CT/pathologic correlation. J Comput Assist Tomogr. 21(6):986-91, 1997
                                                19. Gore RM: Small bowel cancer. Clinical and pathologic features. Radiol Clin North Am. 35(2):351-60, 1997
                                                20. Maglinte DT et al: Small bowel cancer. Radiologic diagnosis. Radiol Clin North Am. 35(2):361-80, 1997
                                                21. Laurent F et al: CT of small-bowel neoplasms. Semin Ultrasound CT MR. 16(2):102-11, 1995
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Duodenal carcinoma (CA)

                                                          • Synonyms

                                                            • Duodenal adenocarcinoma

                                                          • Definitions

                                                            • Primary malignant neoplasm arising in duodenal mucosa

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • Fluoroscopic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Zhu Z et al: Comparative analysis of outcomes and clinicopathological characteristics of duodenal adenocarcinoma: a SEER analysis. Cancer Invest. 1-16, 2020
                                                                                              2. Cloyd JM et al: Duodenal adenocarcinoma: advances in diagnosis and surgical management. World J Gastrointest Surg. 8(3):212-21, 2016
                                                                                              3. Qureshi S et al: Malignant pyloro-duodenal obstruction: role of self expandable metallic stents. J Pak Med Assoc. 64(1):16-9, 2014
                                                                                              4. Wood LD et al: Upper GI tract lesions in familial adenomatous polyposis (FAP): enrichment of pyloric gland adenomas and other gastric and duodenal neoplasms. Am J Surg Pathol. 38(3):389-93, 2014
                                                                                              5. Struck A et al: Non-ampullary duodenal adenocarcinoma: factors important for relapse and survival. J Surg Oncol. 100(2):144-8, 2009
                                                                                              6. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                                                                              7. Lawler LP et al: Peripancreatic masses that simulate pancreatic disease: spectrum of disease and role of CT. Radiographics. 23(5):1117-31, 2003
                                                                                              8. Kim JH et al: Differential diagnosis of periampullary carcinomas at MR imaging. Radiographics. 22(6):1335-52, 2002
                                                                                              9. Korman MU: Radiologic evaluation and staging of small intestine neoplasms. Eur J Radiol. 42(3):193-205, 2002
                                                                                              10. Iki K et al: Primary adenocarcinoma of the duodenum demonstrated by ultrasonography. J Gastroenterol. 36(3):195-9, 2001
                                                                                              11. Ishida H et al: Duodenal carcinoma: sonographic findings. Abdom Imaging. 26(5):469-73, 2001
                                                                                              12. Nagi B et al: Primary small bowel tumors: a radiologic-pathologic correlation. Abdom Imaging. 26(5):474-80, 2001
                                                                                              13. Gore R et al: Textbook of Gastrointestinal Radiology. 2nd ed. Philadelphia, W.B. Saunders, 1980-1992, 2000
                                                                                              14. Buckley JA et al: CT evaluation of small bowel neoplasms: spectrum of disease. Radiographics. 18(2):379-92, 1998
                                                                                              15. Neugut AI et al: The epidemiology of cancer of the small bowel. Cancer Epidemiol Biomarkers Prev. 7(3):243-51, 1998
                                                                                              16. Arber N et al: Molecular genetics of small bowel cancer. Cancer Epidemiol Biomarkers Prev. 6(9):745-8, 1997
                                                                                              17. Buckley JA et al: Small bowel cancer. Imaging features and staging. Radiol Clin North Am. 35(2):381-402, 1997
                                                                                              18. Buckley JA et al: The accuracy of CT staging of small bowel adenocarcinoma: CT/pathologic correlation. J Comput Assist Tomogr. 21(6):986-91, 1997
                                                                                              19. Gore RM: Small bowel cancer. Clinical and pathologic features. Radiol Clin North Am. 35(2):351-60, 1997
                                                                                              20. Maglinte DT et al: Small bowel cancer. Radiologic diagnosis. Radiol Clin North Am. 35(2):361-80, 1997
                                                                                              21. Laurent F et al: CT of small-bowel neoplasms. Semin Ultrasound CT MR. 16(2):102-11, 1995