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EAC Skin Squamous Cell Carcinoma
Hilda E. Stambuk, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Squamous cell carcinoma (SCCa) involving external auditory canal (EAC)

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              • Reporting Tips

                                                Selected References

                                                1. Takenaka Y et al: Chemoradiation therapy for squamous cell carcinoma of the external auditory canal: a meta-analysis. Head Neck. 37(7):1073-80, 2015
                                                2. Xia S et al: Radiological Findings of Malignant Tumors of External Auditory Canal: A Cross-Sectional Study Between Squamous Cell Carcinoma and Adenocarcinoma. Medicine (Baltimore). 94(35):e1452, 2015
                                                3. Zanoletti E et al: A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma. Cancer Treat Rev. 41(10):821-6, 2015
                                                4. Buchmann LO et al: Skin cancers of the external auditory canal. Facial Plast Surg. 29(5):384-8, 2013
                                                5. Morris LG et al: Predictors of survival and recurrence after temporal bone resection for cancer. Head Neck. 34(9):1231-9, 2012
                                                6. Cristalli G et al: Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. J Craniofac Surg. 20(3):816-21, 2009
                                                7. Gidley PW: Managing malignancies of the external auditory canal. Expert Rev Anticancer Ther. 9(9):1277-82, 2009
                                                8. Ito M et al: Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement? Acta Otolaryngol. 129(11):1313-9, 2009
                                                9. Prabhu R et al: Squamous cell carcinoma of the external auditory canal: long-term clinical outcomes using surgery and external-beam radiotherapy. Am J Clin Oncol. 32(4):401-4, 2009
                                                10. Madsen AR et al: Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001. Head Neck. 30(10):1332-8, 2008
                                                11. Ong CK et al: Imaging of carcinoma of the external auditory canal: a pictorial essay. Cancer Imaging. 8:191-8, 2008
                                                12. Ogawa K et al: Treatment and prognosis of squamous cell carcinoma of the external auditory canal and middle ear: a multi-institutional retrospective review of 87 patients. Int J Radiat Oncol Biol Phys. 68(5):1326-34, 2007
                                                13. Pulec JL et al: Squamous cell carcinoma of the external auditory canal. Ear Nose Throat J. 83(1):9, 2004
                                                14. Choi JY et al: Mode of parotid involvement in external auditory canal carcinoma. J Laryngol Otol. 117(12):951-4, 2003
                                                15. Knegt PP et al: Squamous carcinoma of the external auditory canal: a different approach. Clin Otolaryngol. 27(3):183-7, 2002
                                                16. Nyrop M et al: Cancer of the external auditory canal. Arch Otolaryngol Head Neck Surg. 128(7):834-7, 2002
                                                17. Wolfe SG et al: Bilateral squamous cell carcinoma of the external auditory canals. Laryngoscope. 112(6):1003-5, 2002
                                                18. Hashi N et al: The role of radiotherapy in treating squamous cell carcinoma of the external auditory canal, especially in early stages of disease. Radiother Oncol. 56(2):221-5, 2000
                                                19. Lim LH et al: Malignancy of the temporal bone and external auditory canal. Otolaryngol Head Neck Surg. 122(6):882-6, 2000
                                                20. Moody SA et al: Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system. Am J Otol. 21(4):582-8, 2000
                                                21. Kamiya M et al: Pigmented squamous cell carcinoma with dendritic melanocyte colonization in the external auditory canal. Pathol Int. 49(10):909-12, 1999
                                                22. Uchida N et al: Squamous cell carcinoma of the external auditory canal: two cases treated with high dose rate 192Ir remote afterloading system (RALS). Radiat Med. 17(6):443-6, 1999
                                                23. Okada E et al: Fiberscope-assisted evaluation of prereconstructed and postreconstructed external auditory canal. J Craniofac Surg. 9(3):228-32; discussion 233, 1998
                                                24. Testa JR et al: Prognostic factors in carcinoma of the external auditory canal. Arch Otolaryngol Head Neck Surg. 123(7):720-4, 1997
                                                25. Austin JR et al: Squamous cell carcinoma of the external auditory canal. Therapeutic prognosis based on a proposed staging system. Arch Otolaryngol Head Neck Surg. 120(11):1228-32, 1994
                                                26. Prasad S et al: Efficacy of surgical treatments for squamous cell carcinoma of the temporal bone: a literature review. Otolaryngol Head Neck Surg. 110(3):270-80, 1994
                                                27. Kinney SE: Squamous cell carcinoma of the external auditory canal. Am J Otol. 10(2):111-6, 1989
                                                28. Hahn SS et al: Carcinoma of the middle ear and external auditory canal. Int J Radiat Oncol Biol Phys. 9(7):1003-7, 1983
                                                29. Olsen KD et al: Radiographic assessment of squamous cell carcinoma of the temporal bone. Laryngoscope. 93(9):1162-7, 1983
                                                30. Wang CC: Radiation therapy in the management of carcinoma of the external auditory canal, middle ear, or mastoid. Radiology. 116(3):713-5, 1975
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Definitions

                                                              • Squamous cell carcinoma (SCCa) involving external auditory canal (EAC)

                                                            IMAGING

                                                            • General Features

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Consider

                                                                                          • Image Interpretation Pearls

                                                                                            • Reporting Tips

                                                                                              Selected References

                                                                                              1. Takenaka Y et al: Chemoradiation therapy for squamous cell carcinoma of the external auditory canal: a meta-analysis. Head Neck. 37(7):1073-80, 2015
                                                                                              2. Xia S et al: Radiological Findings of Malignant Tumors of External Auditory Canal: A Cross-Sectional Study Between Squamous Cell Carcinoma and Adenocarcinoma. Medicine (Baltimore). 94(35):e1452, 2015
                                                                                              3. Zanoletti E et al: A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma. Cancer Treat Rev. 41(10):821-6, 2015
                                                                                              4. Buchmann LO et al: Skin cancers of the external auditory canal. Facial Plast Surg. 29(5):384-8, 2013
                                                                                              5. Morris LG et al: Predictors of survival and recurrence after temporal bone resection for cancer. Head Neck. 34(9):1231-9, 2012
                                                                                              6. Cristalli G et al: Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. J Craniofac Surg. 20(3):816-21, 2009
                                                                                              7. Gidley PW: Managing malignancies of the external auditory canal. Expert Rev Anticancer Ther. 9(9):1277-82, 2009
                                                                                              8. Ito M et al: Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement? Acta Otolaryngol. 129(11):1313-9, 2009
                                                                                              9. Prabhu R et al: Squamous cell carcinoma of the external auditory canal: long-term clinical outcomes using surgery and external-beam radiotherapy. Am J Clin Oncol. 32(4):401-4, 2009
                                                                                              10. Madsen AR et al: Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001. Head Neck. 30(10):1332-8, 2008
                                                                                              11. Ong CK et al: Imaging of carcinoma of the external auditory canal: a pictorial essay. Cancer Imaging. 8:191-8, 2008
                                                                                              12. Ogawa K et al: Treatment and prognosis of squamous cell carcinoma of the external auditory canal and middle ear: a multi-institutional retrospective review of 87 patients. Int J Radiat Oncol Biol Phys. 68(5):1326-34, 2007
                                                                                              13. Pulec JL et al: Squamous cell carcinoma of the external auditory canal. Ear Nose Throat J. 83(1):9, 2004
                                                                                              14. Choi JY et al: Mode of parotid involvement in external auditory canal carcinoma. J Laryngol Otol. 117(12):951-4, 2003
                                                                                              15. Knegt PP et al: Squamous carcinoma of the external auditory canal: a different approach. Clin Otolaryngol. 27(3):183-7, 2002
                                                                                              16. Nyrop M et al: Cancer of the external auditory canal. Arch Otolaryngol Head Neck Surg. 128(7):834-7, 2002
                                                                                              17. Wolfe SG et al: Bilateral squamous cell carcinoma of the external auditory canals. Laryngoscope. 112(6):1003-5, 2002
                                                                                              18. Hashi N et al: The role of radiotherapy in treating squamous cell carcinoma of the external auditory canal, especially in early stages of disease. Radiother Oncol. 56(2):221-5, 2000
                                                                                              19. Lim LH et al: Malignancy of the temporal bone and external auditory canal. Otolaryngol Head Neck Surg. 122(6):882-6, 2000
                                                                                              20. Moody SA et al: Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system. Am J Otol. 21(4):582-8, 2000
                                                                                              21. Kamiya M et al: Pigmented squamous cell carcinoma with dendritic melanocyte colonization in the external auditory canal. Pathol Int. 49(10):909-12, 1999
                                                                                              22. Uchida N et al: Squamous cell carcinoma of the external auditory canal: two cases treated with high dose rate 192Ir remote afterloading system (RALS). Radiat Med. 17(6):443-6, 1999
                                                                                              23. Okada E et al: Fiberscope-assisted evaluation of prereconstructed and postreconstructed external auditory canal. J Craniofac Surg. 9(3):228-32; discussion 233, 1998
                                                                                              24. Testa JR et al: Prognostic factors in carcinoma of the external auditory canal. Arch Otolaryngol Head Neck Surg. 123(7):720-4, 1997
                                                                                              25. Austin JR et al: Squamous cell carcinoma of the external auditory canal. Therapeutic prognosis based on a proposed staging system. Arch Otolaryngol Head Neck Surg. 120(11):1228-32, 1994
                                                                                              26. Prasad S et al: Efficacy of surgical treatments for squamous cell carcinoma of the temporal bone: a literature review. Otolaryngol Head Neck Surg. 110(3):270-80, 1994
                                                                                              27. Kinney SE: Squamous cell carcinoma of the external auditory canal. Am J Otol. 10(2):111-6, 1989
                                                                                              28. Hahn SS et al: Carcinoma of the middle ear and external auditory canal. Int J Radiat Oncol Biol Phys. 9(7):1003-7, 1983
                                                                                              29. Olsen KD et al: Radiographic assessment of squamous cell carcinoma of the temporal bone. Laryngoscope. 93(9):1162-7, 1983
                                                                                              30. Wang CC: Radiation therapy in the management of carcinoma of the external auditory canal, middle ear, or mastoid. Radiology. 116(3):713-5, 1975