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Emphysema, Centrilobular
Terrance Healey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Centrilobular emphysema (CLE)
            • Synonyms

              • Centriacinar emphysema
              • Proximal acinar emphysema
            • Definitions

              • Enlargement & destruction of respiratory bronchioles located near center of secondary pulmonary lobule

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    • MR Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Gietema HA et al: Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol. 18(6):661-71, 2011
                                            2. Mets OM et al: Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans. JAMA. 306(16):1775-81, 2011
                                            3. Gietema HA et al: Distribution of emphysema in heavy smokers: impact on pulmonary function. Respir Med. 104(1):76-82, 2010
                                            4. Sciurba FC et al: A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 363(13):1233-44, 2010
                                            5. Akira M et al: Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment. AJR Am J Roentgenol. 192(1):267-72, 2009
                                            6. Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
                                            7. Ohno Y et al: Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 177(10):1095-102, 2008
                                            8. Parraga G et al: Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol. 42(6):384-91, 2007
                                            9. Watz H et al: Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observations. Radiology. 236(3):1053-8, 2005
                                            10. Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
                                            11. Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
                                            12. Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
                                            13. Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
                                            14. Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
                                            15. Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Centrilobular emphysema (CLE)
                                                      • Synonyms

                                                        • Centriacinar emphysema
                                                        • Proximal acinar emphysema
                                                      • Definitions

                                                        • Enlargement & destruction of respiratory bronchioles located near center of secondary pulmonary lobule

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • Imaging Recommendations

                                                              • MR Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Gietema HA et al: Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol. 18(6):661-71, 2011
                                                                                      2. Mets OM et al: Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans. JAMA. 306(16):1775-81, 2011
                                                                                      3. Gietema HA et al: Distribution of emphysema in heavy smokers: impact on pulmonary function. Respir Med. 104(1):76-82, 2010
                                                                                      4. Sciurba FC et al: A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 363(13):1233-44, 2010
                                                                                      5. Akira M et al: Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment. AJR Am J Roentgenol. 192(1):267-72, 2009
                                                                                      6. Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
                                                                                      7. Ohno Y et al: Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 177(10):1095-102, 2008
                                                                                      8. Parraga G et al: Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol. 42(6):384-91, 2007
                                                                                      9. Watz H et al: Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observations. Radiology. 236(3):1053-8, 2005
                                                                                      10. Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
                                                                                      11. Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
                                                                                      12. Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
                                                                                      13. Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
                                                                                      14. Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
                                                                                      15. Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995