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Endometrial Carcinoma
Maram Aljuaid, MD; Barton F. Lane, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Malignant proliferation of abnormal endometrial glands

              IMAGING

              • General Features

                • Ultrasonographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Huang YT et al: Current status of magnetic resonance imaging in patients with malignant uterine neoplasms: a review. Korean J Radiol. 20(1):18-33, 2019
                                              2. Nougaret S et al: Endometrial cancer MRI staging: updated guidelines of the European Society of Urogenital Radiology. Eur Radiol. 29(2):792-805, 2019
                                              3. Rabban JT et al: Issues in the differential diagnosis of uterine low-grade endometrioid carcinoma, including mixed endometrial carcinomas: recommendations from the International Society of Gynecological Pathologists. Int J Gynecol Pathol. 38 Suppl 1:S25-39, 2019
                                              4. Clarke MA et al: Association of endometrial cancer risk with postmenopausal bleeding in women: a systematic review and meta-analysis. JAMA Intern Med. 178(9):1210-22, 2018
                                              5. Cunningham RK et al: Adenomyosis: a sonographic diagnosis. Radiographics. 38(5):1576-89, 2018
                                              6. Geng J et al: Contrast-enhanced ultrasound in the diagnosis of endometrial carcinoma: a meta-analysis. Exp Ther Med. 16(6):5310-4, 2018
                                              7. Ueno Y et al: Endometrial carcinoma: MR Imaging-based texture model for preoperative risk stratification-a preliminary analysis. Radiology. 284(3):748-57, 2017
                                              8. Du L et al: Application of FLASH-3D dynamic contrast-enhanced imaging for diagnosis of endometrial carcinoma. Br J Radiol. 89(1066):20160268, 2016
                                              9. Wong A et al: Hereditary syndromes manifesting as endometrial carcinoma: how can pathological features aid risk assessment? Biomed Res Int. 2015:219012, 2015
                                              10. Freeman SJ et al: The revised FIGO staging system for uterine malignancies: implications for MR imaging. Radiographics. 32(6):1805-27, 2012
                                              11. Fowler W et al: Management of endometrial cancer. Womens Health (Lond). 4(5):479-89, 2008
                                              12. Barwick TD et al: Imaging of endometrial adenocarcinoma. Clin Radiol. 61(7):545-55, 2006
                                              13. Messiou C et al: MR staging of endometrial carcinoma. Clin Radiol. 61(10):822-32, 2006
                                              14. Nalaboff KM et al: Imaging the endometrium: disease and normal variants. Radiographics. 21:1409-24, 2001
                                              15. Uterine Cancer: Risk Factors and Prevention. https://www.cancer.net/cancer-types/uterine-cancer/risk-factors-and-prevention
                                              16. Endometrial Cancer Risk Factors. https://www.cancer.org/cancer/endometrial-cancer/causes-risks-prevention/risk-factors.html
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Definitions

                                                            • Malignant proliferation of abnormal endometrial glands

                                                          IMAGING

                                                          • General Features

                                                            • Ultrasonographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Huang YT et al: Current status of magnetic resonance imaging in patients with malignant uterine neoplasms: a review. Korean J Radiol. 20(1):18-33, 2019
                                                                                          2. Nougaret S et al: Endometrial cancer MRI staging: updated guidelines of the European Society of Urogenital Radiology. Eur Radiol. 29(2):792-805, 2019
                                                                                          3. Rabban JT et al: Issues in the differential diagnosis of uterine low-grade endometrioid carcinoma, including mixed endometrial carcinomas: recommendations from the International Society of Gynecological Pathologists. Int J Gynecol Pathol. 38 Suppl 1:S25-39, 2019
                                                                                          4. Clarke MA et al: Association of endometrial cancer risk with postmenopausal bleeding in women: a systematic review and meta-analysis. JAMA Intern Med. 178(9):1210-22, 2018
                                                                                          5. Cunningham RK et al: Adenomyosis: a sonographic diagnosis. Radiographics. 38(5):1576-89, 2018
                                                                                          6. Geng J et al: Contrast-enhanced ultrasound in the diagnosis of endometrial carcinoma: a meta-analysis. Exp Ther Med. 16(6):5310-4, 2018
                                                                                          7. Ueno Y et al: Endometrial carcinoma: MR Imaging-based texture model for preoperative risk stratification-a preliminary analysis. Radiology. 284(3):748-57, 2017
                                                                                          8. Du L et al: Application of FLASH-3D dynamic contrast-enhanced imaging for diagnosis of endometrial carcinoma. Br J Radiol. 89(1066):20160268, 2016
                                                                                          9. Wong A et al: Hereditary syndromes manifesting as endometrial carcinoma: how can pathological features aid risk assessment? Biomed Res Int. 2015:219012, 2015
                                                                                          10. Freeman SJ et al: The revised FIGO staging system for uterine malignancies: implications for MR imaging. Radiographics. 32(6):1805-27, 2012
                                                                                          11. Fowler W et al: Management of endometrial cancer. Womens Health (Lond). 4(5):479-89, 2008
                                                                                          12. Barwick TD et al: Imaging of endometrial adenocarcinoma. Clin Radiol. 61(7):545-55, 2006
                                                                                          13. Messiou C et al: MR staging of endometrial carcinoma. Clin Radiol. 61(10):822-32, 2006
                                                                                          14. Nalaboff KM et al: Imaging the endometrium: disease and normal variants. Radiographics. 21:1409-24, 2001
                                                                                          15. Uterine Cancer: Risk Factors and Prevention. https://www.cancer.net/cancer-types/uterine-cancer/risk-factors-and-prevention
                                                                                          16. Endometrial Cancer Risk Factors. https://www.cancer.org/cancer/endometrial-cancer/causes-risks-prevention/risk-factors.html