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Eosinophilic Disorders
Tomás Franquet, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Simple pulmonary eosinophilia (SPE): Löffler syndrome
            • Eosinophilic granulomatosis with polyangiitis (E-GPA): Churg-Strauss syndrome (latter term is no longer used)
          • Definitions

            • Spectrum of pulmonary disorders associated with
              • Peripheral blood or tissue eosinophilia
              • Increased eosinophils in bronchoalveolar lavage (BAL) fluid
          • Classification

            • Idiopathic eosinophilic pneumonias
              • SPE
              • Acute eosinophilic pneumonia (AEP)
              • Chronic eosinophilic pneumonia (CEP)
              • Idiopathic hypereosinophilic syndrome (IHS)
            • Eosinophilic pneumonias of known cause
              • Allergic bronchopulmonary aspergillosis (ABPA)
              • Bronchocentric granulomatosis (BG)
              • Eosinophilic pneumonia secondary to drug reaction or parasitic infestation
            • Eosinophilic vasculitis
              • E-GPA
            • Diseases occasionally associated with eosinophilic infiltration
              • Idiopathic pulmonary fibrosis, sarcoidosis, cryptogenic organizing pneumonia (COP), hypersensitivity pneumonitis

          IMAGING

          • Radiographic Findings

            • CT Findings

              DIFFERENTIAL DIAGNOSIS

                CLINICAL ISSUES

                • Presentation

                  • Respiratory Symptoms

                    DIAGNOSTIC CHECKLIST

                    • Consider

                      • Image Interpretation Pearls

                        Selected References

                        1. Cottin V: Eosinophilic lung diseases. Clin Chest Med. 37(3):535-56, 2016
                        2. Cottin V et al: Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Eur Respir J. 48(5):1429-1441, 2016
                        3. Katre RS et al: Cardiopulmonary and gastrointestinal manifestations of eosinophil- associated diseases and idiopathic hypereosinophilic syndromes: multimodality imaging approach. Radiographics. 36(2):433-51, 2016
                        4. Price M et al: Imaging of eosinophilic lung diseases. Radiol Clin North Am. 54(6):1151-1164, 2016
                        5. Cordier JF et al: Hypereosinophilic obliterative bronchiolitis: a distinct, unrecognised syndrome. Eur Respir J. 41(5):1126-34, 2013
                        6. Jeong YJ et al: Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. Radiographics. 27(3):617-37; discussion 637-9, 2007
                        7. Kim YK et al: Pulmonary involvement in Churg-Strauss syndrome: an analysis of CT, clinical, and pathologic findings. Eur Radiol. 17(12):3157-65, 2007
                        8. Silva CI et al: Churg-Strauss syndrome: high resolution CT and pathologic findings. J Thorac Imaging. 20(2):74-80, 2005
                        9. Johkoh T et al: Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. Radiology. 216(3):773-80, 2000
                        Related Anatomy
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                        Related Differential Diagnoses
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                        References
                        Tables

                        Tables

                        KEY FACTS

                        • Terminology

                          • Imaging

                            • Top Differential Diagnoses

                              • Diagnostic Checklist

                                TERMINOLOGY

                                • Synonyms

                                  • Simple pulmonary eosinophilia (SPE): Löffler syndrome
                                  • Eosinophilic granulomatosis with polyangiitis (E-GPA): Churg-Strauss syndrome (latter term is no longer used)
                                • Definitions

                                  • Spectrum of pulmonary disorders associated with
                                    • Peripheral blood or tissue eosinophilia
                                    • Increased eosinophils in bronchoalveolar lavage (BAL) fluid
                                • Classification

                                  • Idiopathic eosinophilic pneumonias
                                    • SPE
                                    • Acute eosinophilic pneumonia (AEP)
                                    • Chronic eosinophilic pneumonia (CEP)
                                    • Idiopathic hypereosinophilic syndrome (IHS)
                                  • Eosinophilic pneumonias of known cause
                                    • Allergic bronchopulmonary aspergillosis (ABPA)
                                    • Bronchocentric granulomatosis (BG)
                                    • Eosinophilic pneumonia secondary to drug reaction or parasitic infestation
                                  • Eosinophilic vasculitis
                                    • E-GPA
                                  • Diseases occasionally associated with eosinophilic infiltration
                                    • Idiopathic pulmonary fibrosis, sarcoidosis, cryptogenic organizing pneumonia (COP), hypersensitivity pneumonitis

                                IMAGING

                                • Radiographic Findings

                                  • CT Findings

                                    DIFFERENTIAL DIAGNOSIS

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Respiratory Symptoms

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Cottin V: Eosinophilic lung diseases. Clin Chest Med. 37(3):535-56, 2016
                                              2. Cottin V et al: Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Eur Respir J. 48(5):1429-1441, 2016
                                              3. Katre RS et al: Cardiopulmonary and gastrointestinal manifestations of eosinophil- associated diseases and idiopathic hypereosinophilic syndromes: multimodality imaging approach. Radiographics. 36(2):433-51, 2016
                                              4. Price M et al: Imaging of eosinophilic lung diseases. Radiol Clin North Am. 54(6):1151-1164, 2016
                                              5. Cordier JF et al: Hypereosinophilic obliterative bronchiolitis: a distinct, unrecognised syndrome. Eur Respir J. 41(5):1126-34, 2013
                                              6. Jeong YJ et al: Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. Radiographics. 27(3):617-37; discussion 637-9, 2007
                                              7. Kim YK et al: Pulmonary involvement in Churg-Strauss syndrome: an analysis of CT, clinical, and pathologic findings. Eur Radiol. 17(12):3157-65, 2007
                                              8. Silva CI et al: Churg-Strauss syndrome: high resolution CT and pathologic findings. J Thorac Imaging. 20(2):74-80, 2005
                                              9. Johkoh T et al: Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. Radiology. 216(3):773-80, 2000