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Gastrointestinal
Diagnosis
Esophagus
Inflammation
Eosinophilic Esophagitis
Eosinophilic Esophagitis
Atif Zaheer, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Eosinophilic esophagitis

            • Definitions

              • Inflammatory disease of the esophagus
                • ≥ 15 eosinophils/HPF in 4 random specimens on biopsy
                  • Presence of GI symptoms
                  • Absence of eosinophilic involvement of multiple organs outside GI tract
                  • Absence of parasitic infestation

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • CT Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  • Other methods of diagnosis

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Limketkai BN et al: Epidemiology and implications of concurrent diagnosis of eosinophilic oesophagitis and IBD based on a prospective population-based analysis. Gut. 68(12):2152-60, 2019
                                      2. Dellon ES et al: Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology. 154(2):319-32.e3, 2018
                                      3. Straumann A et al: Diagnosis and treatment of eosinophilic esophagitis. Gastroenterology. 154(2):346-59, 2018
                                      4. Cianferoni A et al: Eosinophilic esophagitis: a comprehensive review. Clin Rev Allergy Immunol. 50(2):159-74, 2016
                                      5. Kindel SJ et al: Eosinophilic esophagitis in children following cardiac transplantation: association with post-transplant lymphoproliferative disorder and other transplant outcomes. Pediatr Transplant. 18(5):491-6, 2014
                                      6. Raheem M et al: The pathophysiology of eosinophilic esophagitis. Front Pediatr. 2:41, 2014
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Eosinophilic esophagitis

                                                • Definitions

                                                  • Inflammatory disease of the esophagus
                                                    • ≥ 15 eosinophils/HPF in 4 random specimens on biopsy
                                                      • Presence of GI symptoms
                                                      • Absence of eosinophilic involvement of multiple organs outside GI tract
                                                      • Absence of parasitic infestation

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      • Other methods of diagnosis

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Limketkai BN et al: Epidemiology and implications of concurrent diagnosis of eosinophilic oesophagitis and IBD based on a prospective population-based analysis. Gut. 68(12):2152-60, 2019
                                                                          2. Dellon ES et al: Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology. 154(2):319-32.e3, 2018
                                                                          3. Straumann A et al: Diagnosis and treatment of eosinophilic esophagitis. Gastroenterology. 154(2):346-59, 2018
                                                                          4. Cianferoni A et al: Eosinophilic esophagitis: a comprehensive review. Clin Rev Allergy Immunol. 50(2):159-74, 2016
                                                                          5. Kindel SJ et al: Eosinophilic esophagitis in children following cardiac transplantation: association with post-transplant lymphoproliferative disorder and other transplant outcomes. Pediatr Transplant. 18(5):491-6, 2014
                                                                          6. Raheem M et al: The pathophysiology of eosinophilic esophagitis. Front Pediatr. 2:41, 2014