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Eosinophilic Fasciitis
Kirkland W. Davis, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Eosinophilic fasciitis (EoF)
            • Synonyms

              • Diffuse fasciitis ± eosinophilia, Shulman syndrome, diffuse fasciitis
            • Definitions

              • Rare disorder affecting fascia that causes swelling, discoloration, and induration of legs and forearms
              • Superficial fascia (a.k.a. cutaneous) in subcutis; deep fascia = peripheral deep fascia along surface of muscles + intermuscular deep fascia

            IMAGING

            • General Features

              • Radiographic Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • CT Findings

                      • Ultrasonographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Microscopic Features

                                  • Etiology

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Guimarães JB et al: Diagnostic imaging of inflammatory myopathies: new concepts and a radiological approach. Curr Rheumatol Rep. 21(3):8, 2019
                                                2. Ihn H: Eosinophilic fasciitis: from pathophysiology to treatment. Allergol Int. 68(4):437-9, 2019
                                                3. Mazori DR et al: Eosinophilic fasciitis: an updated review on diagnosis and treatment. Curr Rheumatol Rep. 19(12):74, 2017
                                                4. Chaudhry AA et al: Necrotizing fasciitis and its mimics: what radiologists need to know. AJR Am J Roentgenol. 204(1):128-39, 2015
                                                5. Kirchgesner T et al: Eosinophilic fasciitis: typical abnormalities, variants and differential diagnosis of fasciae abnormalities using MR imaging. Diagn Interv Imaging. 96(4):341-8, 2015
                                                6. Endo Y et al: Eosinophilic fasciitis: report of two cases and a systematic review of the literature dealing with clinical variables that predict outcome. Clin Rheumatol. 26(9):1445-51, 2007
                                                7. Liou CH et al: Eosinophilic fasciitis in a military recruit: MRI evaluation with clinical correlation. Skeletal Radiol. 32(1):52-7, 2003
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Eosinophilic fasciitis (EoF)
                                                          • Synonyms

                                                            • Diffuse fasciitis ± eosinophilia, Shulman syndrome, diffuse fasciitis
                                                          • Definitions

                                                            • Rare disorder affecting fascia that causes swelling, discoloration, and induration of legs and forearms
                                                            • Superficial fascia (a.k.a. cutaneous) in subcutis; deep fascia = peripheral deep fascia along surface of muscles + intermuscular deep fascia

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  • CT Findings

                                                                    • Ultrasonographic Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Microscopic Features

                                                                                • Etiology

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Guimarães JB et al: Diagnostic imaging of inflammatory myopathies: new concepts and a radiological approach. Curr Rheumatol Rep. 21(3):8, 2019
                                                                                              2. Ihn H: Eosinophilic fasciitis: from pathophysiology to treatment. Allergol Int. 68(4):437-9, 2019
                                                                                              3. Mazori DR et al: Eosinophilic fasciitis: an updated review on diagnosis and treatment. Curr Rheumatol Rep. 19(12):74, 2017
                                                                                              4. Chaudhry AA et al: Necrotizing fasciitis and its mimics: what radiologists need to know. AJR Am J Roentgenol. 204(1):128-39, 2015
                                                                                              5. Kirchgesner T et al: Eosinophilic fasciitis: typical abnormalities, variants and differential diagnosis of fasciae abnormalities using MR imaging. Diagn Interv Imaging. 96(4):341-8, 2015
                                                                                              6. Endo Y et al: Eosinophilic fasciitis: report of two cases and a systematic review of the literature dealing with clinical variables that predict outcome. Clin Rheumatol. 26(9):1445-51, 2007
                                                                                              7. Liou CH et al: Eosinophilic fasciitis in a military recruit: MRI evaluation with clinical correlation. Skeletal Radiol. 32(1):52-7, 2003