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Eosinophilic Gastroenteritis and Esophagitis
Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Eosinophilic esophagitis; eosinophilic gastroenteritis
              • Allergic gastroenteropathy
            • Definitions

              • Inflammatory disease of GI tract characterized by tissue eosinophilia that can involve any or all layers of gut wall
                • "Eosinophilic gastroenteritis" is a misnomer since patients may have identical histologic findings at any portion of gastrointestinal (GI) tract
                • Requires 4 criteria for diagnosis
                  • Presence of GI symptoms
                  • Biopsy proof of eosinophilic infiltration of 1 or more areas of GI tract
                  • Absence of eosinophilic involvement of multiple organs outside GI tract
                  • Absence of parasitic infestation

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • CT Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Kindel SJ et al: Eosinophilic esophagitis in children following cardiac transplantation: Association with post-transplant lymphoproliferative disorder and other transplant outcomes. Pediatr Transplant. ePub, 2014
                                    2. Raheem M et al: The pathophysiology of eosinophilic esophagitis. Front Pediatr. 2:41, 2014
                                    3. Assa'ad A: Eosinophilic gastrointestinal disorders. Allergy Asthma Proc. 30(1):17-22, 2009
                                    4. Atkins D et al: Eosinophilic esophagitis: the newest esophageal inflammatory disease. Nat Rev Gastroenterol Hepatol. 6(5):267-78, 2009
                                    5. Shannon R: Eosinophilic esophagitis in children. Gastroenterol Nurs. 32(2):123-5, 2009
                                    6. Sheikh RA et al: Unusual presentations of eosinophilic gastroenteritis: case series and review of literature. World J Gastroenterol. 15(17):2156-61, 2009
                                    7. Whitney-Miller CL et al: Eosinophilic esophagitis: a retrospective review of esophageal biopsy specimens from 1992 to 2004 at an adult academic medical center. Am J Clin Pathol. 131(6):788-92, 2009
                                    8. Badmos KB et al: Eosinophilic colitis presenting as a right iliac fossa mass--a case report. West Afr J Med. 27(3):175-7, 2008
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • Eosinophilic esophagitis; eosinophilic gastroenteritis
                                                • Allergic gastroenteropathy
                                              • Definitions

                                                • Inflammatory disease of GI tract characterized by tissue eosinophilia that can involve any or all layers of gut wall
                                                  • "Eosinophilic gastroenteritis" is a misnomer since patients may have identical histologic findings at any portion of gastrointestinal (GI) tract
                                                  • Requires 4 criteria for diagnosis
                                                    • Presence of GI symptoms
                                                    • Biopsy proof of eosinophilic infiltration of 1 or more areas of GI tract
                                                    • Absence of eosinophilic involvement of multiple organs outside GI tract
                                                    • Absence of parasitic infestation

                                              IMAGING

                                              • General Features

                                                • Imaging Recommendations

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Kindel SJ et al: Eosinophilic esophagitis in children following cardiac transplantation: Association with post-transplant lymphoproliferative disorder and other transplant outcomes. Pediatr Transplant. ePub, 2014
                                                                      2. Raheem M et al: The pathophysiology of eosinophilic esophagitis. Front Pediatr. 2:41, 2014
                                                                      3. Assa'ad A: Eosinophilic gastrointestinal disorders. Allergy Asthma Proc. 30(1):17-22, 2009
                                                                      4. Atkins D et al: Eosinophilic esophagitis: the newest esophageal inflammatory disease. Nat Rev Gastroenterol Hepatol. 6(5):267-78, 2009
                                                                      5. Shannon R: Eosinophilic esophagitis in children. Gastroenterol Nurs. 32(2):123-5, 2009
                                                                      6. Sheikh RA et al: Unusual presentations of eosinophilic gastroenteritis: case series and review of literature. World J Gastroenterol. 15(17):2156-61, 2009
                                                                      7. Whitney-Miller CL et al: Eosinophilic esophagitis: a retrospective review of esophageal biopsy specimens from 1992 to 2004 at an adult academic medical center. Am J Clin Pathol. 131(6):788-92, 2009
                                                                      8. Badmos KB et al: Eosinophilic colitis presenting as a right iliac fossa mass--a case report. West Afr J Med. 27(3):175-7, 2008