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Eosinophilic Granulomatosis With Polyangiitis
Jorge Alberto Carrillo-Bayona, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Eosinophilic granulomatosis with polyangiitis (E-GPA)
              • Synonyms

                • Churg-Strauss syndrome
                • Allergic angiitis and granulomatosis
              • Definitions

                • Systemic disease characterized by eosinophil-rich and necrotizing granulomatous inflammation often involving respiratory tract and necrotizing vasculitis predominantly affecting small to medium-sized vessels in patients with asthma and eosinophilia

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Cottin V: Eosinophilic lung diseases. Clin Chest Med. 37(3):535-56, 2016
                                        2. Cottin V et al: Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Eur Respir J. 48(5):1429-1441, 2016
                                        3. Price M et al: Imaging of eosinophilic lung diseases. Radiol Clin North Am. 54(6):1151-1164, 2016
                                        4. Greco A et al: Churg-Strauss syndrome. Autoimmun Rev. 14(4):341-348, 2015
                                        5. Mouthon L et al: Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg-Strauss syndrome). J Autoimmun. 48-49:99-103, 2014
                                        6. Dennert RM et al: Cardiac involvement in Churg-Strauss syndrome. Arthritis Rheum. 62(2):627-34, 2010
                                        7. Neumann T et al: Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis. Medicine (Baltimore). 88(4):236-43, 2009
                                        8. Silva CI et al: Churg-Strauss syndrome: high resolution CT and pathologic findings. J Thorac Imaging. 20(2):74-80, 2005
                                        9. Choi YH et al: Thoracic manifestation of Churg-Strauss syndrome: radiologic and clinical findings. Chest. 117(1):117-24, 2000
                                        10. Johkoh T et al: Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. Radiology. 216(3):773-80, 2000
                                        11. Worthy SA et al: Churg-Strauss syndrome: the spectrum of pulmonary CT findings in 17 patients. AJR Am J Roentgenol. 170(2):297-300, 1998
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Eosinophilic granulomatosis with polyangiitis (E-GPA)
                                                    • Synonyms

                                                      • Churg-Strauss syndrome
                                                      • Allergic angiitis and granulomatosis
                                                    • Definitions

                                                      • Systemic disease characterized by eosinophil-rich and necrotizing granulomatous inflammation often involving respiratory tract and necrotizing vasculitis predominantly affecting small to medium-sized vessels in patients with asthma and eosinophilia

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Cottin V: Eosinophilic lung diseases. Clin Chest Med. 37(3):535-56, 2016
                                                                              2. Cottin V et al: Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Eur Respir J. 48(5):1429-1441, 2016
                                                                              3. Price M et al: Imaging of eosinophilic lung diseases. Radiol Clin North Am. 54(6):1151-1164, 2016
                                                                              4. Greco A et al: Churg-Strauss syndrome. Autoimmun Rev. 14(4):341-348, 2015
                                                                              5. Mouthon L et al: Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg-Strauss syndrome). J Autoimmun. 48-49:99-103, 2014
                                                                              6. Dennert RM et al: Cardiac involvement in Churg-Strauss syndrome. Arthritis Rheum. 62(2):627-34, 2010
                                                                              7. Neumann T et al: Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis. Medicine (Baltimore). 88(4):236-43, 2009
                                                                              8. Silva CI et al: Churg-Strauss syndrome: high resolution CT and pathologic findings. J Thorac Imaging. 20(2):74-80, 2005
                                                                              9. Choi YH et al: Thoracic manifestation of Churg-Strauss syndrome: radiologic and clinical findings. Chest. 117(1):117-24, 2000
                                                                              10. Johkoh T et al: Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. Radiology. 216(3):773-80, 2000
                                                                              11. Worthy SA et al: Churg-Strauss syndrome: the spectrum of pulmonary CT findings in 17 patients. AJR Am J Roentgenol. 170(2):297-300, 1998