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Epidermoid Cyst
Kevin R. Moore, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Epidermoid cyst, epidermoid "tumor"
              • Definitions

                • Benign nonneoplastic spinal mass composed of cells embryologically derived from epidermal (skin) elements

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Ultrasonographic Findings

                        • Nonvascular Interventions

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Yin H et al: Surgery and outcomes of six patients with intradural epidermoid cysts in the lumbar spine. World J Surg Oncol. 12(1):50, 2014
                                                2. Fereydoonian NA et al: Intramedullary thoracic spine epidermoid cyst with myelopathic presentations: a report of a rare case. Clin Neurol Neurosurg. 115(6):841-3, 2013
                                                3. Yoon SH et al: An extensive intramedullary epidermoid cyst with a longstanding history of paraplegia: a case report. J Neurol Surg A Cent Eur Neurosurg. 74 Suppl 1:e1-3, 2013
                                                4. Hossini A et al: [Epidermoid cyst of the cisterna magna and the fourth ventricle: Report of four cases.] Neurochirurgie. 58(6):358-63, 2012
                                                5. Kansal R et al: Epidermoid cyst inside anterior sacral meningocele in an adult patient of Currarino syndrome manifesting with meningitis. Turk Neurosurg. 22(5):659-61, 2012
                                                6. Morita M et al: Intraspinal epidermoid tumor of the cauda equina region: seven cases and a review of the literature. J Spinal Disord Tech. 25(5):292-8, 2012
                                                7. Bohara M et al: Posterior fossa epidermoid cysts presenting with unusual radiological appearances--two case reports. Neurol Med Chir (Tokyo). 51(1):85-8, 2011
                                                8. Raghunathan A et al: Primary intracranial sarcomatoid carcinoma arising from a recurrent/residual epidermoid cyst of the cerebellopontine angle: a case report. Am J Surg Pathol. 35(8):1238-43, 2011
                                                9. Nakao Y et al: Malignant transformation 20 years after partial removal of intracranial epidermoid cyst--case report. Neurol Med Chir (Tokyo). 50(3):236-9, 2010
                                                10. Ahmed I et al: Neurosurgical management of intracranial epidermoid tumors in children. Clinical article. J Neurosurg Pediatr. 4(2):91-6, 2009
                                                11. Gonzalvo A et al: Intramedullary spinal epidermoid cyst of the upper thoracic region. J Clin Neurosci. 16(1):142-4, 2009
                                                12. Danzer E et al: Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings. J Neurosurg Pediatr. 2(6):406-13, 2008
                                                13. Tekkök IH: Intramedullary epidermoid cysts. J Neurosurg Spine. 8(2):202-3; author reply 203, 2008
                                                14. Gao B et al: Mollaret meningitis associated with an intraspinal epidermoid cyst. Pediatrics. 120(1):e220-4, 2007
                                                15. Gerlach R et al: Large intramedullary abscess of the spinal cord associated with an epidermoid cyst without dermal sinus. Case report. J Neurosurg Spine. 7(3):357-61, 2007
                                                16. Kukreja K et al: Differentiation between pediatric spinal arachnoid and epidermoid-dermoid cysts: is diffusion-weighted MRI useful? Pediatr Radiol. 37(6):556-60, 2007
                                                17. Ogden AT et al: Intramedullary inclusion cysts of the cervicothoracic junction. Report of two cases in adults and review of the literature. J Neurosurg Spine. 7(2):236-42, 2007
                                                18. Jeong IH et al: Iatrogenic intraspinal epidermoid tumor: case report. Pediatr Neurosurg. 42(6):395-8, 2006
                                                19. Lai SW et al: MRI of epidermoid cyst of the conus medullaris. Spinal Cord. 43(5):320-3, 2005
                                                20. Bretz A et al: Intraspinal epidermoid cyst successfully treated with radiotherapy: case report. Neurosurgery. 53(6):1429-31; discussion 1431-2, 2003
                                                21. Amato VG et al: Intramedullary epidermoid cyst: preoperative diagnosis and surgical management after MRI introduction. Case report and updating of the literature. J Neurosurg Sci. 46(3-4):122-6, 2002
                                                22. Teksam M et al: Intraspinal epidermoid cyst: diffusion-weighted MRI. Neuroradiology. 43(7):572-4, 2001
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Synonyms

                                                              • Epidermoid cyst, epidermoid "tumor"
                                                            • Definitions

                                                              • Benign nonneoplastic spinal mass composed of cells embryologically derived from epidermal (skin) elements

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Nonvascular Interventions

                                                                        • Imaging Recommendations

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Yin H et al: Surgery and outcomes of six patients with intradural epidermoid cysts in the lumbar spine. World J Surg Oncol. 12(1):50, 2014
                                                                                              2. Fereydoonian NA et al: Intramedullary thoracic spine epidermoid cyst with myelopathic presentations: a report of a rare case. Clin Neurol Neurosurg. 115(6):841-3, 2013
                                                                                              3. Yoon SH et al: An extensive intramedullary epidermoid cyst with a longstanding history of paraplegia: a case report. J Neurol Surg A Cent Eur Neurosurg. 74 Suppl 1:e1-3, 2013
                                                                                              4. Hossini A et al: [Epidermoid cyst of the cisterna magna and the fourth ventricle: Report of four cases.] Neurochirurgie. 58(6):358-63, 2012
                                                                                              5. Kansal R et al: Epidermoid cyst inside anterior sacral meningocele in an adult patient of Currarino syndrome manifesting with meningitis. Turk Neurosurg. 22(5):659-61, 2012
                                                                                              6. Morita M et al: Intraspinal epidermoid tumor of the cauda equina region: seven cases and a review of the literature. J Spinal Disord Tech. 25(5):292-8, 2012
                                                                                              7. Bohara M et al: Posterior fossa epidermoid cysts presenting with unusual radiological appearances--two case reports. Neurol Med Chir (Tokyo). 51(1):85-8, 2011
                                                                                              8. Raghunathan A et al: Primary intracranial sarcomatoid carcinoma arising from a recurrent/residual epidermoid cyst of the cerebellopontine angle: a case report. Am J Surg Pathol. 35(8):1238-43, 2011
                                                                                              9. Nakao Y et al: Malignant transformation 20 years after partial removal of intracranial epidermoid cyst--case report. Neurol Med Chir (Tokyo). 50(3):236-9, 2010
                                                                                              10. Ahmed I et al: Neurosurgical management of intracranial epidermoid tumors in children. Clinical article. J Neurosurg Pediatr. 4(2):91-6, 2009
                                                                                              11. Gonzalvo A et al: Intramedullary spinal epidermoid cyst of the upper thoracic region. J Clin Neurosci. 16(1):142-4, 2009
                                                                                              12. Danzer E et al: Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings. J Neurosurg Pediatr. 2(6):406-13, 2008
                                                                                              13. Tekkök IH: Intramedullary epidermoid cysts. J Neurosurg Spine. 8(2):202-3; author reply 203, 2008
                                                                                              14. Gao B et al: Mollaret meningitis associated with an intraspinal epidermoid cyst. Pediatrics. 120(1):e220-4, 2007
                                                                                              15. Gerlach R et al: Large intramedullary abscess of the spinal cord associated with an epidermoid cyst without dermal sinus. Case report. J Neurosurg Spine. 7(3):357-61, 2007
                                                                                              16. Kukreja K et al: Differentiation between pediatric spinal arachnoid and epidermoid-dermoid cysts: is diffusion-weighted MRI useful? Pediatr Radiol. 37(6):556-60, 2007
                                                                                              17. Ogden AT et al: Intramedullary inclusion cysts of the cervicothoracic junction. Report of two cases in adults and review of the literature. J Neurosurg Spine. 7(2):236-42, 2007
                                                                                              18. Jeong IH et al: Iatrogenic intraspinal epidermoid tumor: case report. Pediatr Neurosurg. 42(6):395-8, 2006
                                                                                              19. Lai SW et al: MRI of epidermoid cyst of the conus medullaris. Spinal Cord. 43(5):320-3, 2005
                                                                                              20. Bretz A et al: Intraspinal epidermoid cyst successfully treated with radiotherapy: case report. Neurosurgery. 53(6):1429-31; discussion 1431-2, 2003
                                                                                              21. Amato VG et al: Intramedullary epidermoid cyst: preoperative diagnosis and surgical management after MRI introduction. Case report and updating of the literature. J Neurosurg Sci. 46(3-4):122-6, 2002
                                                                                              22. Teksam M et al: Intraspinal epidermoid cyst: diffusion-weighted MRI. Neuroradiology. 43(7):572-4, 2001