Excessive accumulation of intraspinal fat causing cord compression and neurologic deficits
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nonvascular Interventions
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Kim K et al: Spinal epidural lipomatosis: a review of pathogenesis, characteristics, clinical presentation, and management. Global Spine J. 9(6):658-65, 2019
Ishihara S et al: Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome. Spine J. 19(3):493-500, 2018
Morishita S et al: Lumbar epidural lipomatosis is associated with visceral fat and metabolic disorders. Eur Spine J. 27(7):1653-61, 2018
Papastefan ST et al: Management of idiopathic spinal epidural lipomatosis: a case report and review of the literature. Childs Nerv Syst. 34(4):757-63, 2018
Singh J et al: Neonatal epidural lipomatosis: a rare case. J Pediatr Neurosci. 13(2):267-69, 2018
Yasuda T et al: Clinical and imaging characteristics in patients undergoing surgery for lumbar epidural lipomatosis. BMC Musculoskelet Disord. 19(1):66, 2018
Al-Yafeai R et al: Spinal cord compression secondary to idiopathic thoracic epidural lipomatosis in an adolescent: a case report and review of literature. Int J Surg Case Rep. 37:225-9, 2017
Yildirim B et al: Lumbosacral epidural lipomatosis: a retrospective matched case-control database study. World Neurosurg. 96:209-14, 2016
Andreisek G et al: A systematic review of semiquantitative and qualitative radiologic criteria for the diagnosis of lumbar spinal stenosis. AJR Am J Roentgenol. 201(5):W735-46, 2013
Brennan RC et al: Spinal epidural lipomatosis in children with hematologic malignancies. Ann Hematol. 90(9):1067-74, 2011
Al-Khawaja D et al: Spinal epidural lipomatosis--a brief review. J Clin Neurosci. 15(12):1323-6, 2008
Fassett DR et al: Spinal epidural lipomatosis: a review of its causes and recommendations for treatment. Neurosurg Focus. 16(4):E11, 2004
Geers C et al: Polygonal deformation of the dural sac in lumbar epidural lipomatosis: anatomic explanation by the presence of meningovertebral ligaments. AJNR Am J Neuroradiol. 24(7):1276-82, 2003
Payer M et al: Idiopathic symptomatic epidural lipomatosis of the lumbar spine. Acta Neurochir (Wien). 145(4):315-20; discussion 321, 2003
Dumont-Fischer D et al: Spinal epidural lipomatosis revealing endogenous Cushing's syndrome. Joint Bone Spine. 69(2):222-5, 2002
Lisai P et al: Cauda equina syndrome secondary to idiopathic spinal epidural lipomatosis. Spine (Phila Pa 1976). 26(3):307-9, 2001
Citow JS et al: Thoracic epidural lipomatosis with associated syrinx: case report. Surg Neurol. 53(6):589-91, 2000
Benamou PH et al: Epidural lipomatosis not induced by corticosteroid therapy. Three cases including one in a patient with primary Cushing's disease (review of the literature). Rev Rhum Engl Ed. 63(3):207-12, 1996
Hierholzer J et al: Epidural lipomatosis: case report and literature review. Neuroradiology. 38(4):343-8, 1996
Kumar K et al: Symptomatic epidural lipomatosis secondary to obesity. Case report. J Neurosurg. 85(2):348-50, 1996
Provenzale JM et al: Spinal angiolipomas: MR features. AJNR Am J Neuroradiol. 17(4):713-9, 1996
Zentner J et al: Spinal epidural lipomatosis as a complication of prolonged corticosteroid therapy. J Neurosurg Sci. 39(1):81-5, 1995
Beges C et al: Epidural lipomatosis. Interest of magnetic resonance imaging in a weight-reduction treated case. Spine. 19(2):251-4, 1994
Kuhn MJ et al: Lumbar epidural lipomatosis: the "Y" sign of thecal sac compression. Comput Med Imaging Graph. 18(5):367-72, 1994
Preul MC et al: Spinal angiolipomas. Report of three cases. J Neurosurg. 78(2):280-6, 1993
Roy-Camille R et al: Symptomatic spinal epidural lipomatosis induced by a long-term steroid treatment. Review of the literature and report of two additional cases. Spine. 16(12):1365-71, 1991
Healy ME et al: Demonstration by magnetic resonance of symptomatic spinal epidural lipomatosis. Neurosurgery. 21(3):414-5, 1987
Randall BC et al: Epidural lipomatosis with lumbar radiculopathy: CT appearance. J Comput Assist Tomogr. 10(6):1039-41, 1986
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References
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KEY FACTS
Terminology
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Pathology
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Diagnostic Checklist
TERMINOLOGY
Definitions
Excessive accumulation of intraspinal fat causing cord compression and neurologic deficits
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nonvascular Interventions
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Kim K et al: Spinal epidural lipomatosis: a review of pathogenesis, characteristics, clinical presentation, and management. Global Spine J. 9(6):658-65, 2019
Ishihara S et al: Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome. Spine J. 19(3):493-500, 2018
Morishita S et al: Lumbar epidural lipomatosis is associated with visceral fat and metabolic disorders. Eur Spine J. 27(7):1653-61, 2018
Papastefan ST et al: Management of idiopathic spinal epidural lipomatosis: a case report and review of the literature. Childs Nerv Syst. 34(4):757-63, 2018
Singh J et al: Neonatal epidural lipomatosis: a rare case. J Pediatr Neurosci. 13(2):267-69, 2018
Yasuda T et al: Clinical and imaging characteristics in patients undergoing surgery for lumbar epidural lipomatosis. BMC Musculoskelet Disord. 19(1):66, 2018
Al-Yafeai R et al: Spinal cord compression secondary to idiopathic thoracic epidural lipomatosis in an adolescent: a case report and review of literature. Int J Surg Case Rep. 37:225-9, 2017
Yildirim B et al: Lumbosacral epidural lipomatosis: a retrospective matched case-control database study. World Neurosurg. 96:209-14, 2016
Andreisek G et al: A systematic review of semiquantitative and qualitative radiologic criteria for the diagnosis of lumbar spinal stenosis. AJR Am J Roentgenol. 201(5):W735-46, 2013
Brennan RC et al: Spinal epidural lipomatosis in children with hematologic malignancies. Ann Hematol. 90(9):1067-74, 2011
Al-Khawaja D et al: Spinal epidural lipomatosis--a brief review. J Clin Neurosci. 15(12):1323-6, 2008
Fassett DR et al: Spinal epidural lipomatosis: a review of its causes and recommendations for treatment. Neurosurg Focus. 16(4):E11, 2004
Geers C et al: Polygonal deformation of the dural sac in lumbar epidural lipomatosis: anatomic explanation by the presence of meningovertebral ligaments. AJNR Am J Neuroradiol. 24(7):1276-82, 2003
Payer M et al: Idiopathic symptomatic epidural lipomatosis of the lumbar spine. Acta Neurochir (Wien). 145(4):315-20; discussion 321, 2003
Dumont-Fischer D et al: Spinal epidural lipomatosis revealing endogenous Cushing's syndrome. Joint Bone Spine. 69(2):222-5, 2002
Lisai P et al: Cauda equina syndrome secondary to idiopathic spinal epidural lipomatosis. Spine (Phila Pa 1976). 26(3):307-9, 2001
Citow JS et al: Thoracic epidural lipomatosis with associated syrinx: case report. Surg Neurol. 53(6):589-91, 2000
Benamou PH et al: Epidural lipomatosis not induced by corticosteroid therapy. Three cases including one in a patient with primary Cushing's disease (review of the literature). Rev Rhum Engl Ed. 63(3):207-12, 1996
Hierholzer J et al: Epidural lipomatosis: case report and literature review. Neuroradiology. 38(4):343-8, 1996
Kumar K et al: Symptomatic epidural lipomatosis secondary to obesity. Case report. J Neurosurg. 85(2):348-50, 1996
Provenzale JM et al: Spinal angiolipomas: MR features. AJNR Am J Neuroradiol. 17(4):713-9, 1996
Zentner J et al: Spinal epidural lipomatosis as a complication of prolonged corticosteroid therapy. J Neurosurg Sci. 39(1):81-5, 1995
Beges C et al: Epidural lipomatosis. Interest of magnetic resonance imaging in a weight-reduction treated case. Spine. 19(2):251-4, 1994
Kuhn MJ et al: Lumbar epidural lipomatosis: the "Y" sign of thecal sac compression. Comput Med Imaging Graph. 18(5):367-72, 1994
Preul MC et al: Spinal angiolipomas. Report of three cases. J Neurosurg. 78(2):280-6, 1993
Roy-Camille R et al: Symptomatic spinal epidural lipomatosis induced by a long-term steroid treatment. Review of the literature and report of two additional cases. Spine. 16(12):1365-71, 1991
Healy ME et al: Demonstration by magnetic resonance of symptomatic spinal epidural lipomatosis. Neurosurgery. 21(3):414-5, 1987
Randall BC et al: Epidural lipomatosis with lumbar radiculopathy: CT appearance. J Comput Assist Tomogr. 10(6):1039-41, 1986
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