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Esophageal Cancer
Paula Vergara-Wentland, MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        TERMINOLOGY

        • Definitions

          • Squamous cell carcinoma
            • Malignant transformation of squamous epithelium
          • Adenocarcinoma
            • Arises from columnar epithelium (Barrett mucosa)
            • Siewert tumor type should be assessed in all patients with adenocarcinoma involving esophagogastric junction (EGJ)
              • Type I: Lower esophagus, center 1-5 cm above EGJ
              • Type II: Cardiac, center 1 cm above and 2 cm below EGJ
              • Type III: Subcardial, center 2-5 cm below EGJ; considered gastric cancer

        IMAGING

        • PET Findings

          • Other Imaging Recommendations

            DIFFERENTIAL DIAGNOSIS

              PATHOLOGY

              • General Features

                • Staging, Grading, & Classification

                  CLINICAL ISSUES

                  • Demographics

                    • Natural History & Prognosis

                      • Treatment

                        DIAGNOSTIC CHECKLIST

                        • F-18 FDG PET/CT

                          Selected References

                          1. Ajani JA et al: Esophageal and esophagogastric junction cancers, version 1.2015. J Natl Compr Canc Netw. 13(2):194-227, 2015
                          2. Calais J et al: High FDG uptake areas on pre-radiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for locally advanced oesophageal cancer. Eur J Nucl Med Mol Imaging. 42(6):858-67, 2015
                          3. Goense L et al: Diagnostic performance of 18F-FDG and PET/CT for the detection of recurrent esophageal cancer after treatment with curative intent: a systematic review and meta-analysis. J Nucl Med. 56(7): 995-1002, 2015
                          4. Kukar M et al: Role of Repeat 18F-Fluorodeoxyglucose Positron Emission Tomography Examination In Predicting Pathologic Response Following Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma. JAMA Surg. ePub, 2015
                          Related Anatomy
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                          Related Differential Diagnoses
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                          References
                          Tables

                          Tables

                          KEY FACTS

                          • Terminology

                            • Imaging

                              • Top Differential Diagnoses

                                TERMINOLOGY

                                • Definitions

                                  • Squamous cell carcinoma
                                    • Malignant transformation of squamous epithelium
                                  • Adenocarcinoma
                                    • Arises from columnar epithelium (Barrett mucosa)
                                    • Siewert tumor type should be assessed in all patients with adenocarcinoma involving esophagogastric junction (EGJ)
                                      • Type I: Lower esophagus, center 1-5 cm above EGJ
                                      • Type II: Cardiac, center 1 cm above and 2 cm below EGJ
                                      • Type III: Subcardial, center 2-5 cm below EGJ; considered gastric cancer

                                IMAGING

                                • PET Findings

                                  • Other Imaging Recommendations

                                    DIFFERENTIAL DIAGNOSIS

                                      PATHOLOGY

                                      • General Features

                                        • Staging, Grading, & Classification

                                          CLINICAL ISSUES

                                          • Demographics

                                            • Natural History & Prognosis

                                              • Treatment

                                                DIAGNOSTIC CHECKLIST

                                                • F-18 FDG PET/CT

                                                  Selected References

                                                  1. Ajani JA et al: Esophageal and esophagogastric junction cancers, version 1.2015. J Natl Compr Canc Netw. 13(2):194-227, 2015
                                                  2. Calais J et al: High FDG uptake areas on pre-radiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for locally advanced oesophageal cancer. Eur J Nucl Med Mol Imaging. 42(6):858-67, 2015
                                                  3. Goense L et al: Diagnostic performance of 18F-FDG and PET/CT for the detection of recurrent esophageal cancer after treatment with curative intent: a systematic review and meta-analysis. J Nucl Med. 56(7): 995-1002, 2015
                                                  4. Kukar M et al: Role of Repeat 18F-Fluorodeoxyglucose Positron Emission Tomography Examination In Predicting Pathologic Response Following Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma. JAMA Surg. ePub, 2015