Squamous cell carcinoma (SCCa): Malignant transformation of squamous epithelium
Adenocarcinoma: Malignant dysplasia in columnar metaplasia (Barrett mucosa)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Elsherif SB et al: Role of precision imaging in esophageal cancer. J Thorac Dis. 12(9):5159-76, 2020
Wang QL et al: Global time trends in the incidence of esophageal squamous cell carcinoma. Clin Epidemiol. 10:717-28, 2018
Rice TW et al: 8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice. Ann Cardiothorac Surg. 6(2):119-30, 2017
Griffin Y: Esophageal cancer: role of imaging in primary staging and response assessment post neoadjuvant therapy. Semin Ultrasound CT MR. 37(4):339-51, 2016
Karashima R et al: Advantages of FDG-PET/CT over CT alone in the preoperative assessment of lymph node metastasis in patients with esophageal cancer. Surg Today. 45(4):471-7, 2014
Napier KJ et al: Esophageal cancer: a Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol. 6(5):112-20, 2014
Lewis RB et al: From the radiologic pathology archives: esophageal neoplasms: radiologic-pathologic correlation. Radiographics. 33(4):1083-108, 2013
Bird-Lieberman EL et al: Early diagnosis of oesophageal cancer. Br J Cancer. 101(1):1-6, 2009
Herszényi L et al: Diagnosis and recognition of early esophageal neoplasia. Dig Dis. 27(1):24-30, 2009
Gupta S et al: Usefulness of barium studies for differentiating benign and malignant strictures of the esophagus. AJR Am J Roentgenol. 180(3):737-44, 2003
Klein CA et al: Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma. Cancer Res. 69(13):5285-8, 2009
Lee PC et al: Predictors of long-term survival after resection of esophageal carcinoma with nonregional nodal metastases. Ann Thorac Surg. 88(1):186-92; discussion 192-3, 2009
Malin E et al: Multimodality treatment for esophageal malignancy: the roles of surgery and neoadjuvant therapy. Am Surg. 75(6):489-97, 2009
Morganstern B et al: GERD and Barrett's esophagus: diagnostic and management strategies in the geriatric population. Geriatrics. 64(7):9-12, 2009
Iyer RB et al: Diagnosis, staging, and follow-up of esophageal cancer. AJR Am J Roentgenol. 181(3):785-93, 2003
Levine MS et al: Carcinoma of the esophagus and esophagogastric junction: sensitivity of radiographic diagnosis. AJR Am J Roentgenol. 168(6):1423-6, 1997
Levine MS et al: Fibrovascular polyps of the esophagus: clinical, radiographic, and pathologic findings in 16 patients. AJR Am J Roentgenol. 166(4):781-7, 1996
Glick SN: Barium studies in patients with Barrett's esophagus: importance of focal areas of esophageal deformity. AJR Am J Roentgenol. 163(1):65-7, 1994
Vilgrain V et al: Staging of esophageal carcinoma: comparison of results with endoscopic sonography and CT. AJR Am J Roentgenol. 155(2):277-81, 1990
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Definitions
Squamous cell carcinoma (SCCa): Malignant transformation of squamous epithelium
Adenocarcinoma: Malignant dysplasia in columnar metaplasia (Barrett mucosa)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Elsherif SB et al: Role of precision imaging in esophageal cancer. J Thorac Dis. 12(9):5159-76, 2020
Wang QL et al: Global time trends in the incidence of esophageal squamous cell carcinoma. Clin Epidemiol. 10:717-28, 2018
Rice TW et al: 8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice. Ann Cardiothorac Surg. 6(2):119-30, 2017
Griffin Y: Esophageal cancer: role of imaging in primary staging and response assessment post neoadjuvant therapy. Semin Ultrasound CT MR. 37(4):339-51, 2016
Karashima R et al: Advantages of FDG-PET/CT over CT alone in the preoperative assessment of lymph node metastasis in patients with esophageal cancer. Surg Today. 45(4):471-7, 2014
Napier KJ et al: Esophageal cancer: a Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol. 6(5):112-20, 2014
Lewis RB et al: From the radiologic pathology archives: esophageal neoplasms: radiologic-pathologic correlation. Radiographics. 33(4):1083-108, 2013
Bird-Lieberman EL et al: Early diagnosis of oesophageal cancer. Br J Cancer. 101(1):1-6, 2009
Herszényi L et al: Diagnosis and recognition of early esophageal neoplasia. Dig Dis. 27(1):24-30, 2009
Gupta S et al: Usefulness of barium studies for differentiating benign and malignant strictures of the esophagus. AJR Am J Roentgenol. 180(3):737-44, 2003
Klein CA et al: Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma. Cancer Res. 69(13):5285-8, 2009
Lee PC et al: Predictors of long-term survival after resection of esophageal carcinoma with nonregional nodal metastases. Ann Thorac Surg. 88(1):186-92; discussion 192-3, 2009
Malin E et al: Multimodality treatment for esophageal malignancy: the roles of surgery and neoadjuvant therapy. Am Surg. 75(6):489-97, 2009
Morganstern B et al: GERD and Barrett's esophagus: diagnostic and management strategies in the geriatric population. Geriatrics. 64(7):9-12, 2009
Iyer RB et al: Diagnosis, staging, and follow-up of esophageal cancer. AJR Am J Roentgenol. 181(3):785-93, 2003
Levine MS et al: Carcinoma of the esophagus and esophagogastric junction: sensitivity of radiographic diagnosis. AJR Am J Roentgenol. 168(6):1423-6, 1997
Levine MS et al: Fibrovascular polyps of the esophagus: clinical, radiographic, and pathologic findings in 16 patients. AJR Am J Roentgenol. 166(4):781-7, 1996
Glick SN: Barium studies in patients with Barrett's esophagus: importance of focal areas of esophageal deformity. AJR Am J Roentgenol. 163(1):65-7, 1994
Vilgrain V et al: Staging of esophageal carcinoma: comparison of results with endoscopic sonography and CT. AJR Am J Roentgenol. 155(2):277-81, 1990
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