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Extramedullary Hematopoiesis
Anne G. Osborn, MD, FACR; Charles Raybaud, MD, FRCPC
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Extramedullary hematopoiesis (EMH)
            • Synonyms

              • Extramedullary erythropoiesis
            • Definitions

              • Extramedullary compensatory formation of blood elements due to decreased medullary hematopoiesis

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Mehta S et al: Intracranial extramedullary haematopoiesis: A case report. Br J Neurosurg. 1-3, 2015
                                            2. Mughal TI et al: Myelofibrosis-associated complications: pathogenesis, clinical manifestations, and effects on outcomes. Int J Gen Med. 7:89-101, 2014
                                            3. Singer A et al: Intracranial extramedullary hematopoiesis: a rare cause of headaches. J Neuroimaging. 24(5):524-7, 2014
                                            4. Ghieda U et al: Progressive spinal cord compression due to epidural extramedullary hematopoiesis in thalassemia intermedia. A case report and literature review. Neuroradiol J. 26(1):111-7, 2013
                                            5. Palma JA et al: Intracranial extramedullary hematopoiesis associated with multiple myeloma. Neurology. 80(17):1620, 2013
                                            6. Tefferi A: Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management. Am J Hematol. 88(2):141-50, 2013
                                            7. Eskazan AE et al: Intracranial extramedullary hematopoiesis in patients with thalassemia: a case report and review of the literature. Transfusion. 52(8):1715-20, 2012
                                            8. Sohawon D et al: Extra-medullary haematopoiesis: a pictorial review of its typical and atypical locations. J Med Imaging Radiat Oncol. 56(5):538-44, 2012
                                            9. Jiang WX et al: 37-year-old woman with multiple intracranial masses. Brain Pathol. 21(5):607-10, 2011
                                            10. Zherebitskiy V et al: Extramedullary hematopoiesis involving the central nervous system and surrounding structures. Hum Pathol. Epub ahead of print, 2011
                                            11. Debard A et al: Dural localization of extramedullary hematopoiesis. Report of a case. J Neurol. 256(5):837-8, 2009
                                            12. Tun K et al: Meningeal extramedullary haematopoiesis mimicking subdural hematoma. J Clin Neurosci. 15(2):208-10, 2008
                                            13. Collins WO et al: Extramedullary hematopoiesis of the paranasal sinuses in sickle cell disease. Otolaryngol Head Neck Surg. 132(6):954-6, 2005
                                            14. Koch CA et al: Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 78(10):1223-33, 2003
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Extramedullary hematopoiesis (EMH)
                                                      • Synonyms

                                                        • Extramedullary erythropoiesis
                                                      • Definitions

                                                        • Extramedullary compensatory formation of blood elements due to decreased medullary hematopoiesis

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Mehta S et al: Intracranial extramedullary haematopoiesis: A case report. Br J Neurosurg. 1-3, 2015
                                                                                      2. Mughal TI et al: Myelofibrosis-associated complications: pathogenesis, clinical manifestations, and effects on outcomes. Int J Gen Med. 7:89-101, 2014
                                                                                      3. Singer A et al: Intracranial extramedullary hematopoiesis: a rare cause of headaches. J Neuroimaging. 24(5):524-7, 2014
                                                                                      4. Ghieda U et al: Progressive spinal cord compression due to epidural extramedullary hematopoiesis in thalassemia intermedia. A case report and literature review. Neuroradiol J. 26(1):111-7, 2013
                                                                                      5. Palma JA et al: Intracranial extramedullary hematopoiesis associated with multiple myeloma. Neurology. 80(17):1620, 2013
                                                                                      6. Tefferi A: Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management. Am J Hematol. 88(2):141-50, 2013
                                                                                      7. Eskazan AE et al: Intracranial extramedullary hematopoiesis in patients with thalassemia: a case report and review of the literature. Transfusion. 52(8):1715-20, 2012
                                                                                      8. Sohawon D et al: Extra-medullary haematopoiesis: a pictorial review of its typical and atypical locations. J Med Imaging Radiat Oncol. 56(5):538-44, 2012
                                                                                      9. Jiang WX et al: 37-year-old woman with multiple intracranial masses. Brain Pathol. 21(5):607-10, 2011
                                                                                      10. Zherebitskiy V et al: Extramedullary hematopoiesis involving the central nervous system and surrounding structures. Hum Pathol. Epub ahead of print, 2011
                                                                                      11. Debard A et al: Dural localization of extramedullary hematopoiesis. Report of a case. J Neurol. 256(5):837-8, 2009
                                                                                      12. Tun K et al: Meningeal extramedullary haematopoiesis mimicking subdural hematoma. J Clin Neurosci. 15(2):208-10, 2008
                                                                                      13. Collins WO et al: Extramedullary hematopoiesis of the paranasal sinuses in sickle cell disease. Otolaryngol Head Neck Surg. 132(6):954-6, 2005
                                                                                      14. Koch CA et al: Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 78(10):1223-33, 2003