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Extramedullary Hematopoiesis
Santiago Martínez-Jiménez, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Proliferation of hematopoietic cells outside bone marrow when marrow hematopoiesis fails

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Bowling MR et al: Pulmonary extramedullary hematopoiesis. J Thorac Imaging. 23(2):138-41, 2008
                                        2. Berkmen YM et al: Case 126: extramedullary hematopoiesis. Radiology. 245(3):905-8, 2007
                                        3. Ghosh AK et al: Primary extramedullary hematopoiesis manifesting as massive bilateral chylothorax. Ann Thorac Surg. 80(4):1515-7, 2005
                                        4. Castelli R et al: Intrathoracic masses due to extramedullary hematopoiesis. Am J Med Sci. 328(5):299-303, 2004
                                        5. Koch CA et al: Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 78(10):1223-33, 2003
                                        6. Georgiades CS et al: Typical and atypical presentations of extramedullary hemopoiesis. AJR Am J Roentgenol. 179(5):1239-43, 2002
                                        7. Xiros N et al: Massive hemothorax due to intrathoracic extramedullary hematopoiesis in a patient with hereditary spherocytosis. Ann Hematol. 80(1):38-40, 2001
                                        8. Kwak HS et al: CT findings of extramedullary hematopoiesis in the thorax, liver and kidneys, in a patient with idiopathic myelofibrosis. J Korean Med Sci. 15(4):460-2, 2000
                                        9. Tsitouridis J et al: Extramedullary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation. Eur J Radiol. 30(1):33-8, 1999
                                        10. Moran CA et al: Extramedullary hematopoiesis presenting as posterior mediastinal mass: a study of four cases. Mod Pathol. 8(3):249-51, 1995
                                        11. De Klippel N et al: Progressive paraparesis due to thoracic extramedullary hematopoiesis in myelofibrosis. Case report. J Neurosurg. 79(1):125-7, 1993
                                        12. Martin J et al: Fatty transformation of thoracic extramedullary hematopoiesis following splenectomy: CT features. J Comput Assist Tomogr. 14(3):477-8, 1990
                                        13. Papavasiliou C et al: The marrow heterotopia in thalassemia. Eur J Radiol. 6(2):92-6, 1986
                                        14. Long JA et al: Computed tomographic studies of thoracic extramedullary hematopoiesis. J Comput Assist Tomogr. 4(1):67-70, 1980
                                        15. Mulder H et al: Extramedullary hematopoiesis in the posterior mediastinum. Radiol Clin (Basel). 44(6):550-6, 1975
                                        16. Korsten J et al: Extramedullary hematopoiesis in patients with thalassemia anemia. Radiology. 95(2):257-63, 1970
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Proliferation of hematopoietic cells outside bone marrow when marrow hematopoiesis fails

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Bowling MR et al: Pulmonary extramedullary hematopoiesis. J Thorac Imaging. 23(2):138-41, 2008
                                                                              2. Berkmen YM et al: Case 126: extramedullary hematopoiesis. Radiology. 245(3):905-8, 2007
                                                                              3. Ghosh AK et al: Primary extramedullary hematopoiesis manifesting as massive bilateral chylothorax. Ann Thorac Surg. 80(4):1515-7, 2005
                                                                              4. Castelli R et al: Intrathoracic masses due to extramedullary hematopoiesis. Am J Med Sci. 328(5):299-303, 2004
                                                                              5. Koch CA et al: Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 78(10):1223-33, 2003
                                                                              6. Georgiades CS et al: Typical and atypical presentations of extramedullary hemopoiesis. AJR Am J Roentgenol. 179(5):1239-43, 2002
                                                                              7. Xiros N et al: Massive hemothorax due to intrathoracic extramedullary hematopoiesis in a patient with hereditary spherocytosis. Ann Hematol. 80(1):38-40, 2001
                                                                              8. Kwak HS et al: CT findings of extramedullary hematopoiesis in the thorax, liver and kidneys, in a patient with idiopathic myelofibrosis. J Korean Med Sci. 15(4):460-2, 2000
                                                                              9. Tsitouridis J et al: Extramedullary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation. Eur J Radiol. 30(1):33-8, 1999
                                                                              10. Moran CA et al: Extramedullary hematopoiesis presenting as posterior mediastinal mass: a study of four cases. Mod Pathol. 8(3):249-51, 1995
                                                                              11. De Klippel N et al: Progressive paraparesis due to thoracic extramedullary hematopoiesis in myelofibrosis. Case report. J Neurosurg. 79(1):125-7, 1993
                                                                              12. Martin J et al: Fatty transformation of thoracic extramedullary hematopoiesis following splenectomy: CT features. J Comput Assist Tomogr. 14(3):477-8, 1990
                                                                              13. Papavasiliou C et al: The marrow heterotopia in thalassemia. Eur J Radiol. 6(2):92-6, 1986
                                                                              14. Long JA et al: Computed tomographic studies of thoracic extramedullary hematopoiesis. J Comput Assist Tomogr. 4(1):67-70, 1980
                                                                              15. Mulder H et al: Extramedullary hematopoiesis in the posterior mediastinum. Radiol Clin (Basel). 44(6):550-6, 1975
                                                                              16. Korsten J et al: Extramedullary hematopoiesis in patients with thalassemia anemia. Radiology. 95(2):257-63, 1970