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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- High-grade, malignant, biphasic, primitive mesenchymal tumor containing well-differentiated, organized hyaline cartilage component
- ~ 40% of cases affect somatic soft tissue
- Histologic types of lesions that account for extraskeletal chondrosarcoma are myxoid chondrosarcoma, mesenchymal chondrosarcoma, and, very rarely, low-grade chondrosarcoma
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Fanburg-Smith JC et al: Mesenchymal chondrosarcoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press, 2020
- Kao YC et al: What is new about the molecular genetics in matrix-producing soft tissue tumors? The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 476(1):121-34, 2020
- Stacchiotti S et al: Extraskeletal myxoid chondrosarcoma: state of the art and current research on biology and clinical management. Cancers (Basel). 12(9), 2020
- Gupta SR et al: A rare case of extraskeletal mesenchymal chondrosarcoma with dedifferentiation arising from the buccal space in a young male. J Maxillofac Oral Surg. 14(Suppl 1):293-9, 2015
- Kransdorf MJ et al: Extraskeletal osseous and cartilaginous lesions. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 580-3, 2014
- Herrera A et al: Primary orbital mesenchymal chondrosarcoma: case report and review of the literature. Case Rep Med. 2012:292147, 2012
- Weiss SW et al: Cartilaginous soft tissue tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 1031-6, 2008
- Anderson JT et al: Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. J Hand Surg Am. 32(3):389-92, 2007
- Pellitteri PK et al: Mesenchymal chondrosarcoma of the head and neck. Oral Oncol. 43(10):970-5, 2007
- Hashimoto N et al: Extraskeletal mesenchymal chondrosarcoma: an imaging review of ten new patients. Skeletal Radiol. 34(12):785-92, 2005
- Murphey MD et al. Imaging of primary chondrosarcoma: radiologic-pathologic correlation. RadioGraphics 23:1245-78. 2003
- Shapeero LG et al: Extraskeletal mesenchymal chondrosarcoma. Radiology. 186(3):819-26, 1993
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- High-grade, malignant, biphasic, primitive mesenchymal tumor containing well-differentiated, organized hyaline cartilage component
- ~ 40% of cases affect somatic soft tissue
- Histologic types of lesions that account for extraskeletal chondrosarcoma are myxoid chondrosarcoma, mesenchymal chondrosarcoma, and, very rarely, low-grade chondrosarcoma
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Angiographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Fanburg-Smith JC et al: Mesenchymal chondrosarcoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press, 2020
- Kao YC et al: What is new about the molecular genetics in matrix-producing soft tissue tumors? The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 476(1):121-34, 2020
- Stacchiotti S et al: Extraskeletal myxoid chondrosarcoma: state of the art and current research on biology and clinical management. Cancers (Basel). 12(9), 2020
- Gupta SR et al: A rare case of extraskeletal mesenchymal chondrosarcoma with dedifferentiation arising from the buccal space in a young male. J Maxillofac Oral Surg. 14(Suppl 1):293-9, 2015
- Kransdorf MJ et al: Extraskeletal osseous and cartilaginous lesions. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 580-3, 2014
- Herrera A et al: Primary orbital mesenchymal chondrosarcoma: case report and review of the literature. Case Rep Med. 2012:292147, 2012
- Weiss SW et al: Cartilaginous soft tissue tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 1031-6, 2008
- Anderson JT et al: Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. J Hand Surg Am. 32(3):389-92, 2007
- Pellitteri PK et al: Mesenchymal chondrosarcoma of the head and neck. Oral Oncol. 43(10):970-5, 2007
- Hashimoto N et al: Extraskeletal mesenchymal chondrosarcoma: an imaging review of ten new patients. Skeletal Radiol. 34(12):785-92, 2005
- Murphey MD et al. Imaging of primary chondrosarcoma: radiologic-pathologic correlation. RadioGraphics 23:1245-78. 2003
- Shapeero LG et al: Extraskeletal mesenchymal chondrosarcoma. Radiology. 186(3):819-26, 1993
