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Extraskeletal Osteosarcoma
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD; Stephanie A. Bernard, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Soft tissue osteosarcoma
          • Definitions

            • Malignant mesenchymal soft tissue tumor that synthesizes osteoid, bone, or chondroid material, excluding similar lesions that arise from bone

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Angiographic Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Veselis CA et al: Bone tumors occurring in the soft tissues: a review of the clinical, imaging, and histopathologic findings. Curr Probl Diagn Radiol. 50(3):419-29, 2021
                                      2. Kao YC et al: What is new about the molecular genetics in matrix-producing soft tissue tumors? The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 476(1):121-34, 2020
                                      3. Yamashita K et al: Extraskeletal osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 224-5, 2020
                                      4. Roller LA et al: Clinical, radiological, and pathological features of extraskeletal osteosarcoma. Skeletal Radiol. 47(9):1213-20, 2018
                                      5. Kransdorf MJ et al: Extraskeletal osseous and cartilaginous lesions. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 572-5, 2014
                                      6. Mc Auley G et al: Extraskeletal osteosarcoma: spectrum of imaging findings. AJR Am J Roentgenol. 198(1):W31-7, 2012
                                      7. Beall DP et al: Pediatric extraskeletal osteosarcoma. Pediatr Radiol. 38(5):579-82, 2008
                                      8. Weiss SW et al: Osseus soft tissue tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 1051-9, 2008
                                      9. Konishi E et al: Extraskeletal osteosarcoma arising in myositis ossificans. Skeletal Radiol. 30(1):39-43, 2001
                                      10. Dubec JJ et al: Soft tissue osteosarcoma with telangiectatic features: MR imaging findings in two cases. Skeletal Radiol. 26(12):732-6, 1997
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Soft tissue osteosarcoma
                                              • Definitions

                                                • Malignant mesenchymal soft tissue tumor that synthesizes osteoid, bone, or chondroid material, excluding similar lesions that arise from bone

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        • Angiographic Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Veselis CA et al: Bone tumors occurring in the soft tissues: a review of the clinical, imaging, and histopathologic findings. Curr Probl Diagn Radiol. 50(3):419-29, 2021
                                                                          2. Kao YC et al: What is new about the molecular genetics in matrix-producing soft tissue tumors? The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 476(1):121-34, 2020
                                                                          3. Yamashita K et al: Extraskeletal osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 224-5, 2020
                                                                          4. Roller LA et al: Clinical, radiological, and pathological features of extraskeletal osteosarcoma. Skeletal Radiol. 47(9):1213-20, 2018
                                                                          5. Kransdorf MJ et al: Extraskeletal osseous and cartilaginous lesions. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 572-5, 2014
                                                                          6. Mc Auley G et al: Extraskeletal osteosarcoma: spectrum of imaging findings. AJR Am J Roentgenol. 198(1):W31-7, 2012
                                                                          7. Beall DP et al: Pediatric extraskeletal osteosarcoma. Pediatr Radiol. 38(5):579-82, 2008
                                                                          8. Weiss SW et al: Osseus soft tissue tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 1051-9, 2008
                                                                          9. Konishi E et al: Extraskeletal osteosarcoma arising in myositis ossificans. Skeletal Radiol. 30(1):39-43, 2001
                                                                          10. Dubec JJ et al: Soft tissue osteosarcoma with telangiectatic features: MR imaging findings in two cases. Skeletal Radiol. 26(12):732-6, 1997